Control of fluid flow in a fluidic network is provided by controlling phase transitions of a phase-change material between a liquid phase and a non-fluid phase. The phase-change material is disposed at ports of the fluidic network where the fluidic network is in communication with an ambient. This advantageously provides control of pressure-driven flow within the fluidic network without altering properties of fluids within the fluidic network.

A manually actuated chromatography device comprising a chamber for receiving a liquid sample, a pump with a metering valve, and a chromatography element, wherein the pump moves a predetermined volume of liquid from the sample chamber to the chromatography element.

An instrument for processing a biological sample includes a chassis. Connected to the chassis is a tape path along which a tape with a matrix of wells can be automatically advanced through the instrument, a dispensing assembly for dispensing the biological sample and a reagent into the matrix of wells of the tape to form a biological sample and reagent mixture, a sealing assembly for sealing the biological sample and reagent mixture in the tape, and an amplification and detection assembly for detecting a signal from the biological sample and reagent mixture in the matrix of wells in the tape.

This disclosure is directed to a device and a system for picking a target analyte of a suspension. A picker introduces at least one force, such as by a magnetic gradient and/or by a pressure gradient, to extract the target analyte from a sample.

Embodiments in accordance with the present disclosure are directed to sample collecting and dispensing methods and apparatuses. An example apparatus includes a capillary sampler disposed on a device first end, wherein the capillary sampler is configured to collect a fluid sample via an opening and a capillary body. The apparatus further includes a reagents chamber in fluid communication with the capillary sampler, and a barrier assembly disposed between the capillary sampler and the reagents chamber, wherein the barrier assembly is configured to separate fluid in the reagents chamber from the capillary sampler. A plunger assembly disposed on a device second end opposite the device first end, may modify the barrier assembly to dispense the fluid from the reagents chamber to the capillary sampler responsive to application of a force in the direction of the device first end.

A microfluidic device (10) comprising: a main body; at least one source reservoir and at least one collection reservoir (18,20); at least one fluid channel (12) for channelling a fluid comprising a compound from the at least one source reservoir (18) to the at least one collection reservoir (20); a plurality of chambers (13) for holding cells, wherein the plurality of chambers (13) are formed underneath and open to the fluid channel (12), wherein a fluid flow is generated through the at least one fluid channel (12) by a difference in hydrostatic pressure between fluid in the at least one source reservoir (18) and fluid the at least one collection reservoir (20) such that the fluid flow provides a compound concentration gradient across the plurality of chambers (13) and wherein the at least one collection reservoir (20) has an overflow opening (32) to substantially maintain a level of hydrostatic pressure in the at least one collection reservoir (20).

A system for analysis of a sample to aid in diagnosis and/or detection of the presence or absence, and/or the identity of, an analyte in the sample is provided. A cartridge with reagents to isolate nucleic acid from a sample inserted in the cartridge and to amplify the isolated nucleic acid, and an instrument that interacts with the cartridge, together provide a self-contained sample to answer system for detection, identification, differentiation and/or quantification of a target nucleic acid in a sample.

The present disclosure provides microfluidic test platforms, systems, and methods for manufacturing the disclosed test platforms. The present disclosure further provides uses of the disclosed microfluidic test platforms in personalized medicine. Specifically, in providing prognostic and therapeutic methods for determining drug sensitivity and optimizing treatment regimen for subjects suffering from a pathologic disorder, specifically, cancer.

A device for measuring a cryogenic liquid level is disclosed. The device includes an inner cylindrical tube, an outer cylindrical tube that is coaxial with the inner cylindrical tube, the outer tube separated from the inner tube by an air gap, wherein the air gap is exposed to environmental pressure but sealed against cryogenic liquid, and a pressure transducer in pressure communication with the inner tube. The outer and inner tubes may be inserted into a cryogenic fluid chamber, and the depth of the cryogenic liquid may be determined based on the pressure present in the inner tube and detected by the pressure transducer.

A housing for a simulation chamber having a chamber body, a door arranged on the chamber body, and a controller housing, wherein the controller housing is arranged on the chamber body and comprises an outer surface, an inner surface, and at least one side surface, in that the door comprises an outer surface, an inner surface, and at least five side surfaces, wherein the controller housing is arranged on the chamber body in such a manner that, when the door is closed, at least one of the side surfaces of the door is arranged facing at least one of the side surfaces of the controller housing.