The present disclosure relates to methods and devices for the separation of blood components including separation by rapid sedimentation, including in an automated fashion.

A fluid separation device includes a centrifuge in which a fluid is separated into at least two components, with an interface therebetween. At least a portion of one of the separated fluid components is removed from the centrifuge and flows through a vessel. Light is reflected off of the separated fluid component in the vessel and received and analyzed to determine its main wavelength. If the main wavelength is higher than a maximum value, a target location of the interface is changed. If the main wavelength is less than the maximum value, then the location of the interface is compared to the target location. When the interface is sufficiently close to the target location, the optical density of the separated fluid component in the vessel is compared to a minimum value. If the optical density is less than the minimum value, the target location of the interface is changed.

A rotor for use in a centrifuge, and adapters for coupling one or more processing containers to the rotor. The rotor includes a rotor body having a plurality of receptacles each configured to receive an adapter. Each adapter includes an outer surface configured to interface with one of the receptacles, and one or more cavities each configured to accept a processing container. The rotor may also include a rotor liner positioned between the adapters and the rotor body. The rotor liner engages the receptacles of the rotor body, and provides a plurality of receptacles that receive the adapters, thereby providing an interface between the adapters and the receptacles of the rotor body.

The present embodiments relate to a fluid control device using centrifugal force. The fluid control device using centrifugal force includes a fluid control portion comprising a plurality of chambers and controlling a movement of a fluid inside the chamber; a lower fixing portion positioned on a lower portion of the fluid control portion and fixing the plurality of chambers; an upper fixing portion positioned an on upper portion of the fluid control portion and fixing the plurality of chambers; and a fastening member penetrating and fastening the lower fixing portion, the fluid control portion, and the upper fixing portion, wherein the plurality of chambers are disposed to face each other and placed on the lower fixing portion.

The present embodiments relate to a fluid control device using centrifugal force. The fluid control device using centrifugal force includes a fluid control portion comprising a plurality of chambers and controlling a movement of a fluid inside the chamber; a lower fixing portion positioned on a lower portion of the fluid control portion and fixing the plurality of chambers; an upper fixing portion positioned an on upper portion of the fluid control portion and fixing the plurality of chambers; and a fastening member penetrating and fastening the lower fixing portion, the fluid control portion, and the upper fixing portion, wherein the plurality of chambers are disposed to face each other and placed on the lower fixing portion.

A portable motorized centrifugal system is optimized for low cost manufacture and operation. Separation of inhomogeneous fluid biological samples, such as liquid plasma from whole blood, is a common step in medical diagnostic tests. This system may enable remote separation where access to plug-in power sources are limited. The system may facilitate at-home testing. Due to biohazard concerns, the entire centrifugal apparatus portable and disposable, or the system includes one or more disposable elements within the interior of the centrifuge. Alternatively, the system may contain a module of higher value components that are re-usable after disinfection. Devices and methods for implementing centrifugal separation may include disk-shaped fluidic cartridges and tubes with reduced drag cross-section.

A swing rotor assembly for a centrifuge. The swing rotor assembly includes a driving unit including a motor, a mounting cap on the motor, and a transmission charging module on the mounting cap to wirelessly charge the battery; a rotor header including a case in which U-shaped curved portions are formed for mounting a bucket while being mounted and rotated on a motor driving shaft, an angle maintaining unit mounted inside the case to control an angle of the bucket and discharge a centrifuged sample, a battery mounted inside the case to drive the angle maintaining unit, a reception charging module on the case to wirelessly charge the battery, and a rotation shaft unit inside the case and rotatably supported at both sides of the bucket; and a bucket on the rotation shaft unit and rotating up and down by a centrifugal force while rotating together with the rotor header.

A modular cassette and method for separating a composite fluid into at least two component parts thereof during centrifugation is provided. The modular cassette includes a fluid inlet portion, at least one fluid separation portion, at least one media chamber in fluid communication with the fluid separation portion, a fluid collection portion, at least one fluidic channel configured to form a fluid communication between at least two components of the cassette, at least one wax valve including undulating flow channel portions configured to close at least one of the fluidic channels, and at least one heating element configured to actuate the at least one wax valve.

Apparatus and methods for separating blood components are disclosed in which an apparatus for separating blood generally includes a tube defining a channel and configured for receiving a quantity of blood and a float contained within the tube and having a density which is predefined so that the float is maintained at equilibrium between a first layer formed from a first fractional component of the blood and a second layer formed from a second fractional component of the blood. Upon completion of the centrifugation, the first layer may be removed from the tube while the float isolates the second layer from the first layer.

A rotor assembly that includes a fixed-angle rotor with a plurality of rotor wells that each have a central axis in a fixed angular relationship relative to a rotational axis of the rotor to define a rotor well angle for each rotor well, and further includes an adapter for use with one of the rotor wells. The adapter includes a body with a circular cross-sectional shape that extends between a first end and a second end, and a sample tube cavity formed in the body. The cavity extends from an opening at the first end of the body to a closed base at the second end of the body and includes a longitudinal axis. When the adapter is positioned within the rotor well, the longitudinal axis of the cavity has an angular relationship relative to the rotational axis of the rotor that is different compared to the rotor well angle.