B04B7/08

Centrifugal smearing device and sealed rotating container

The present invention addresses the problem of providing a centrifugal smearing device and a sealed rotating container in which liquid components do not leak to an outside of the sealed rotating container. To solve this problem, in a centrifugal smearing device (30) including a sealed rotating container (34) that houses a chamber (10) with a slide glass removably attached for holding the liquid sample to smear cells in the liquid sample with a centrifugal force onto the slide glass, and a base (31) housing the sealed rotating container (34) and including rotational driving means (32) for rotating the sealed rotating container (34), the sealed rotating container (34) includes a main body (40) capable of housing the chamber (10) and a lid (42) for closing an upper surface opening portion of the main body (40), and has a storage section (46) for storing liquid scattered from the chamber (10) during being centrifuged, formed on an inside face of the main body (40).

DEVICES AND DISPOSABLES FOR PATIENT-SPECIFIC CELL THERAPY MANUFACTURING

The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (42), a pump (64) and a plurality of valves (1-11) configured to at least partially control fluid flow through a fluid circuitry and a separation column (40) positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.

DEVICES AND DISPOSABLES FOR PATIENT-SPECIFIC CELL THERAPY MANUFACTURING

The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (42), a pump (64) and a plurality of valves (1-11) configured to at least partially control fluid flow through a fluid circuitry and a separation column (40) positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.

SEPARATOR
20170333915 · 2017-11-23 ·

A separator for centrifugally processing a flowable product includes a rotatable drum bounding a centrifuging chamber. The drum has a feeding and removal system having at least one feeding device and one or more removal devices composed of plastic or a plastic composite. An inner drum, composed of plastic or a plastic composite, is arranged in an outer supporting device of the drum. The feeding device and the one or more removal devices extend into the inner drum, do not rotate with the inner drum during operation, and are glued and/or welded to each other in such a way that the feeding device and the one or more removal devices are sealingly connected. The feeding and removal system has one or more grippers as the removal device, each of which one or two or more grippers has a disk segment and a shaft segment.

SEPARATOR
20170333915 · 2017-11-23 ·

A separator for centrifugally processing a flowable product includes a rotatable drum bounding a centrifuging chamber. The drum has a feeding and removal system having at least one feeding device and one or more removal devices composed of plastic or a plastic composite. An inner drum, composed of plastic or a plastic composite, is arranged in an outer supporting device of the drum. The feeding device and the one or more removal devices extend into the inner drum, do not rotate with the inner drum during operation, and are glued and/or welded to each other in such a way that the feeding device and the one or more removal devices are sealingly connected. The feeding and removal system has one or more grippers as the removal device, each of which one or two or more grippers has a disk segment and a shaft segment.

CENTRIFUGE ROTOR CORE WITH PARTIAL CHANNELS

A rotor core is provided that includes a rotor length defined along an axis of rotation and a plurality of separation channels. The plurality of separation channels having a channel length extending along the axis of rotation a distance that is less than the rotor length. A rotor assembly is also provided that includes such a rotor core removably disposed in an outer housing.

EXCHANGEABLE SEPARATION INSERT
20220055043 · 2022-02-24 · ·

An exchangeable separation insert for a centrifugal separator includes a rotor casing enclosing a separation space in which a stack of separation discs is arranged, and first and second stationary portions. A feed inlet supplies a fluid mixture to the separation space. The insert includes a light phase outlet and a heavy phase outlet. The feed inlet is arranged at a first axial end of the rotor casing. One of the light phase outlet and heavy phase outlet is arranged at a second axial end. A first rotatable seal seals and connects the feed inlet and a second rotatable seal seals and connects one of the light phase outlet and heavy phase outlet.

SCREW CENTRIFUGE FOR WET MECHANICAL SEPARATION OF SOLIDS

A screw centrifuge has a rotating, cylindrical drum (11) with openings (14,15) for discharge of settleable solids (16), floating solids (17), and separating liquid (18). A rotatable shaft (12) has openings (22) for infeed of the solids to be separated, and two sections of screw flights (13,13′,13″,23,23′) working in opposite directions. A baffle disc (20) is arranged on the shaft between the infeed opening (22) and the discharge opening (14) for the settleable solids (16). The flight (13′,13″) of the screw for the settleable solids (16) surrounds the flight (23,23′) of the screw for the floating solids (17), and also work in opposite directions. The screw section for the floating solids (17) is designed as a multi-channel screw. The outer flight (13′,13″) of the screw for the settleable solids (16) can also have several channels.

Equipment and procedure for culturing, separating, and genetically modifying donor cells for reinfusion into a patient

The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (42), a pump (64) and a plurality of valves (1-11) configured to at least partially control fluid flow through a fluid circuitry and a separation column (40) positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.

Equipment and procedure for culturing, separating, and genetically modifying donor cells for reinfusion into a patient

The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (42), a pump (64) and a plurality of valves (1-11) configured to at least partially control fluid flow through a fluid circuitry and a separation column (40) positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.