A separator includes a housing that is stationary during operation and is a tank having at least two openings. A drum is located inside the housing, has a vertical axis of rotation, and a number of openings to the housing corresponding to the openings of the housing. A single multi-part support and drive device with at least one control device and a motor including of a stator, a stator magnet assembly, and a rotor with a rotor magnet assembly, which keep the drum suspended inside the housing, radially and axially supported, and set in rotation. The stator magnet assembly is located outside the housing and the rotor magnet assembly is located inside the housing on the drum so that an air gap is formed between the housing and the drum while the drum is rotating during operation. The axial support and centering of the drum is implemented by controlling the axial position of the rotor magnet assembly using the control device by actuating the motor.

A rotary vessel for a filter assembly has a rotor body rotatable about an axis of rotation and a spigot with a non-circular cross-section and integral with or coupled to the rotor body. The spigot extends away from the rotor body along the axis of rotation and engages with a bearing. The spigot facilitates transfer of rotary motion between the rotor body and the bearing. A filter assembly has a housing with a main body and a closure member separably attachable to the main body. The rotary vessel is disposed inside the housing. The closure member retains the rotary vessel inside the housing and is separable from the main body to permit removal of the rotary vessel from the housing. The spigot integral with or coupled to the rotor vessel engages with a bearing of the filter assembly to rotatably support the rotary vessel in the housing.

A rotary vessel for a filter assembly has a rotor body rotatable about an axis of rotation and a spigot with a non-circular cross-section and integral with or coupled to the rotor body. The spigot extends away from the rotor body along the axis of rotation and engages with a bearing. The spigot facilitates transfer of rotary motion between the rotor body and the bearing. A filter assembly has a housing with a main body and a closure member separably attachable to the main body. The rotary vessel is disposed inside the housing. The closure member retains the rotary vessel inside the housing and is separable from the main body to permit removal of the rotary vessel from the housing. The spigot integral with or coupled to the rotor vessel engages with a bearing of the filter assembly to rotatably support the rotary vessel in the housing.

A separator insert includes a housing that is stationary during operation and which is a container that is closed apart from a number of openings. A rotor is arranged within the housing and is rotatable about an axis of rotation. The separator insert includes a drum with openings. At least two rotor units for magnetic bearing units are arranged at two axially spaced apart points on the rotor with the drum, that hold the rotor in a suspended state and that can rotate the rotor.

A separator insert includes a housing that is stationary during operation and which is a container that is closed apart from a number of openings. A rotor is arranged within the housing and is rotatable about an axis of rotation. The separator insert includes a drum with openings. At least two rotor units for magnetic bearing units are arranged at two axially spaced apart points on the rotor with the drum, that hold the rotor in a suspended state and that can rotate the rotor.

A base unit and a modular centrifugal separator are disclosed. The base unit includes a stationary frame, a rotatable member, and a drive unit. The rotatable member delimits an inner space being configured for receiving at least one part of an exchangeable separation insert therein. The rotatable member is provided with a first opening at a first axial end configured for a first fluid connection of the exchangeable separation insert to extend through the first opening. The rotatable member includes a second opening at a second axial end configured for a second fluid connection of the exchangeable separation insert to extend through the second opening.

A centrifugal separator for separation of a cell culture mixture includes a stationary frame, a rotatable assembly and a drive unit for rotating the rotatable assembly relative the frame around a vertical axis of rotation. The rotatable assembly includes a rotor casing enclosing a separation space in which a stack of separation discs is arranged to rotate around an axis of rotation. The rotor casing includes a mechanically hermetically sealed inlet and first and second mechanically hermetically sealed liquid outlets. The second mechanically hermetically sealed outlet is arranged at an axial end of the rotor casing opposite and arranged so that a separated cell phase is discharged at the rotational axis. The rotatable assembly includes an exchangeable separation insert and a rotatable member.

A centrifugal separator for separation of a cell culture mixture includes a stationary frame, a rotatable assembly and a drive unit for rotating the rotatable assembly relative the frame around a vertical axis of rotation. The rotatable assembly includes a rotor casing enclosing a separation space in which a stack of separation discs is arranged to rotate around an axis of rotation. The rotor casing includes a mechanically hermetically sealed inlet and first and second mechanically hermetically sealed liquid outlets. The second mechanically hermetically sealed outlet is arranged at an axial end of the rotor casing opposite and arranged so that a separated cell phase is discharged at the rotational axis. The rotatable assembly includes an exchangeable separation insert and a rotatable member.

A separation assembly comprises a housing and a bearing plate assembly. The housing contains a turbine assembly and a rotor portion and defines a fluid inlet and a fluid outlet. The bearing plate assembly is adjustably attachable to the housing and defines a drive jet that directs fluid from the fluid inlet to the turbine assembly. The bearing plate assembly is mountable to the housing in multiple different orientations such that the relative position of the fluid inlet of the housing and the drive jet of the bearing plate assembly is adjustable.

A separation assembly comprises a housing and a bearing plate assembly. The housing contains a turbine assembly and a rotor portion and defines a fluid inlet and a fluid outlet. The bearing plate assembly is adjustably attachable to the housing and defines a drive jet that directs fluid from the fluid inlet to the turbine assembly. The bearing plate assembly is mountable to the housing in multiple different orientations such that the relative position of the fluid inlet of the housing and the drive jet of the bearing plate assembly is adjustable.