A blood washing system (20) having a rotor (22) defining an internal chamber for receiving a multi-component fluid and a skimmer assembly (24) including a moveable buoy (28) having an orifice (32) fluidly connected to an access port for the rotor for selectively withdrawing separated fractions of the multi-component fluid. The multi-component fluid can be fed into the internal chamber before the rotor (22) can be rotated at a first speed to fractionate the multi-component fluid. A brake can be applied to the rotor to slow rotation of the rotor to a slower second speed or stop rotation of the rotor causing the solid and denser fluid fractions to settle on the bottom wall (44) of the rotor (22). The buoy (28) can have a specific gravity corresponding to a selected fraction such that the buoy floats on a surface of the selected fraction, wherein the fractions floating on the selected fraction can be withdrawn through the orifice (32).

Provided are compositions and processes concerning efficient downstream processing of products derived from organic acids pretreatment of plant materials.

Provided are compositions and processes concerning efficient downstream processing of products derived from organic acids pretreatment of plant materials.

A centrifugal separator having a device for the transformation of kinetic energy of a liquid rotating in a discharge chamber around a rotational axis to pressure energy includes a discharge element for the discharge of liquid out of the discharge chamber, which discharge element has a radially outer part shaped as a body of revolution about the rotational axis and is arranged to be located in a rotating liquid body in the discharge chamber, and at least one outlet channel formed in the discharge element and having an inlet opening located in a surface of the body of revolution and elongated in the liquid flow direction, the inlet opening connecting to the interior of an outlet tube via the outlet channel. The outlet channel has a defined axial height and a defined width which vary along their extension from the inlet opening to the connection to the outlet tube in such a way that a defined aspect ratio h/w decreases along at least a part of the extension of the outlet channel. A defined aspect ratio h/w is larger than 1 in an outer first part of the outlet channel and decreases to smaller than 1 in an inner second part of the outlet channel and the height decreases inwardly along the length of the outlet channel.

The present invention relates, in part, to methods, systems and processes for large-scale purification of mRNA using a filtering centrifuge operating at lower gravitational forces. The invention also relates to compositions of purified mRNA and uses thereof.

The present invention relates, in part, to methods, systems and processes for large-scale purification of mRNA using a filtering centrifuge operating at lower gravitational forces. The invention also relates to compositions of purified mRNA and uses thereof.

A filter unit (10) for separation of particulate matter from particulate-laden liquid, the filter unit comprising: a chamber (12) defined by an upper axial end wall (14) and an opposing lower axial end wall (16) and a peripheral particle collection wall (18), the upper and lower axial end walls being spaced by the peripheral particle collection wall, the chamber being rotatable about an axis of rotation (30) so as to impart rotational motion to the liquid; an inlet (23) for delivering particulate-laden liquid into the chamber (12); an outlet (24) in the upper or lower axial end wall for discharging filtered liquid from the chamber; a flow path (22) from the inlet to the outlet; wherein the flow path includes a radial component from the inlet to the peripheral particle collection wall and an axial component along the peripheral particle collection wall.

A filter unit (10) for separation of particulate matter from particulate-laden liquid, the filter unit comprising: a chamber (12) defined by an upper axial end wall (14) and an opposing lower axial end wall (16) and a peripheral particle collection wall (18), the upper and lower axial end walls being spaced by the peripheral particle collection wall, the chamber being rotatable about an axis of rotation (30) so as to impart rotational motion to the liquid; an inlet (23) for delivering particulate-laden liquid into the chamber (12); an outlet (24) in the upper or lower axial end wall for discharging filtered liquid from the chamber; a flow path (22) from the inlet to the outlet; wherein the flow path includes a radial component from the inlet to the peripheral particle collection wall and an axial component along the peripheral particle collection wall.

An outlet device (24) of a separator (10) has an outlet channel (38) for discharging a liquid phase from a rotating drum of the separator (10). The outlet channel (38) extends along a rotational axis (16) in a fixed tube device (42) of the separator (10). A cap (74) is connected fixedly to the tube device (42), surrounds the tube device (42), and covers the drum in the radial direction.

Provided herein are compositions and processes concerning efficient downstream processing of products derived from organic acids pretreatment of plant materials.