The invention is directed to compositions and processes concerning efficient downstream processing of products derived from organic acids pretreatment of plant materials.

The invention is directed to compositions and processes concerning efficient downstream processing of products derived from organic acids pretreatment of plant materials.

A centrifugal separator having a device for the transformation of kinetic energy of a liquid rotating in a discharge chamber around a rotational axis to pressure energy includes a discharge element for the discharge of liquid out of the discharge chamber, which discharge element has a radially outer part shaped as a body of revolution about the rotational axis and is arranged to be located in a rotating liquid body in the discharge chamber, and at least one outlet channel formed in the discharge element and having an inlet opening located in a surface of the body of revolution and elongated in the liquid flow direction, the inlet opening connecting to the interior of an outlet tube via the outlet channel. The outlet channel has a defined axial height and a defined width which vary along their extension from the inlet opening to the connection to the outlet tube in such a way that a defined aspect ratio h/w decreases along at least a part of the extension of the outlet channel. A defined aspect ratio h/w is larger than 1 in an outer first part of the outlet channel and decreases to smaller than 1 in an inner second part of the outlet channel and the height decreases inwardly along the length of the outlet channel.

The botanical extraction and purification device described in this patent provide the ability to extract and purify botanical compounds from a diverse plant species through specially crafted process sequences that effectively reach the desired botanical component despite differences in botanical material types and unique differences in organic chemical characteristics. The technological package consists of two main processing centers; each is a combination of process features that can be personalized to effectively address unique extraction requirements. When combined, the extraction processes deliver capabilities in product throughput speed and product purity not available using previously available separation methods. The first component of this package is a CUP that transfers chemical compounds from botanical material into a solvent. The second component is an AISP. This device separates unwanted botanical compounds from the solvent, resulting in a relatively pure plant extract.

The botanical extraction and purification device described in this patent provide the ability to extract and purify botanical compounds from a diverse plant species through specially crafted process sequences that effectively reach the desired botanical component despite differences in botanical material types and unique differences in organic chemical characteristics. The technological package consists of two main processing centers; each is a combination of process features that can be personalized to effectively address unique extraction requirements. When combined, the extraction processes deliver capabilities in product throughput speed and product purity not available using previously available separation methods. The first component of this package is a CUP that transfers chemical compounds from botanical material into a solvent. The second component is an AISP. This device separates unwanted botanical compounds from the solvent, resulting in a relatively pure plant extract.

An apparatus for separating cell suspension material into centrate and concentrate, includes a single use structure (178, 240, 250) releasably positioned in a cavity in a solid wall rotatable centrifuge bowl (172). The bowl and portions of single use structure rotate about an axis (174). A stationary inlet feed tube (184), a centrate discharge tube (212) and a concentrate discharge tube (230) extend along the axis of the rotating single use structure. A centrate centripetal pump (208) is in fluid connection with the centrate discharge tube. A concentrate centripetal pump (216) is in fluid connection with the concentrate discharge tube. A controller (274) operates responsive to sensors (264, 270) in respective centrate and concentrate discharge lines (262, 268), to control flow rates of a concentrate pump (272) and a centrate pump (266) to produce output flows of cell concentrate and generally cell free centrate.

A method and apparatus for separating cell suspension into centrate and concentrate includes a solid wall rotatable centrifuge bowl (82). A single use rotatable core (88) is positioned in the bowl and bounds a cavity (90) which serves as a separation chamber. The bowl rotates about an axis (84). An inlet tube (92) and an outlet tube (102) extend along the axis in the bowl cavity. The centripetal pump (98) in the cavity is in connection with the outlet tube. The centrate discharge pump (120) is in connection with the outlet tube. A pressure damping reservoir (122) is fluidly connected between the outlet tube and the discharge pump. At least one control circuit (142) is operative to control the apparatus to maintain a positive pressure above atmospheric pressure within the cavity, so as to maintain the cell suspension away from at least one seal (106) that bounds the interior of the cavity.

An apparatus for separating cell suspension material into centrate and concentrate, includes a single use structure (178, 240, 250) releasably positioned in a cavity in a solid wall rotatable centrifuge bowl (172). The bowl and portions of single use structure rotate about an axis (174). A stationary inlet feed tube (184), a centrate discharge tube (212) and a concentrate discharge tube (230) extend along the axis of the rotating single use structure. A centrate centripetal pump (208) is in fluid connection with the centrate discharge tube. A concentrate centripetal pump (216) is in fluid connection with the concentrate discharge tube. A controller (274) operates responsive to sensors (264, 270) in respective centrate and concentrate discharge lines (262, 268), to control flow rates of a concentrate pump (272) and a centrate pump (266) to produce output flows of cell concentrate and generally cell free centrate.

The botanical extraction and purification device described in this patent provide the ability to extract and purify botanical compounds from a diverse plant species through specially crafted process sequences that effectively reach the desired botanical component despite differences in botanical material types and unique differences in organic chemical characteristics. The technological package consists of two main processing centers; each is a combination of process features that can be personalized to effectively address unique extraction requirements. When combined, the extraction processes deliver capabilities in product throughput speed and product purity not available using previously available separation methods. The first component of this package is a CUP that transfers chemical compounds from botanical material into a solvent. The second component is an AISP. This device separates unwanted botanical compounds from the solvent, resulting in a relatively pure plant extract.

Provided are compositions and processes concerning efficient downstream processing of products derived from organic acids pretreatment of plant materials.