A centrifuge includes a chamber configured to contain a set of one or more samples, an image sensor configured to generate image data, and processing circuitry. The processing circuitry is configured to: initiate centrifugation of the set of samples about a central axis; obtain a set of image data generated by the image sensor during centrifugation of the set of samples; and for each respective sample of the set of samples, apply a machine learning model configured to generate, based on image data representative of the respective sample in the set of image data, a viability score for the respective sample; determine whether the viability score for the respective sample satisfies a viability condition; and output whether the viability score for the respective sample satisfies the viability condition.

The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (42), a pump (64) and a plurality of valves (1-11) configured to at least partially control fluid flow through a fluid circuitry and a separation column (40) positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.

The present invention relates to a method for separating lymphocytes and/or stem cells from whole blood in an automated blood separation system, wherein the quality of the collected lymphocytes and/or stem cells fractions is increased and the cell collection procedure is further automated by use of an optical sensor comprised in a detector device to measure turbidity and colour in the claimed method and in a cell separator, which can be used to perform the claimed method. The method of the invention is particularly useful to collect lymphocytes and/or stem cells fractions from whole blood, wherein the contamination of the collected cell fractions by platelets, red blood cells and granulocytes is reduced.

The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (42), a pump (64) and a plurality of valves (1-11) configured to at least partially control fluid flow through a fluid circuitry and a separation column (40) positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.

The invention relates to a centrifuge (10), comprising a rotor (12), a drive shaft (14), on which the rotor (12) is supported, a motor (18), which drives the rotor (12) by means of the drive shaft (14), a supporting unit (30) having damping elements (36), each of which comprises a spring axis (36a), which supporting unit supports a rotational unit (19), which comprises the motor (18) together with the drive shaft (14) and the rotor (12), a sensor unit (82, 84) for sensing the rotational speed, a distance sensor (80) for determining imbalances of the rotational unit (19), which rotational unit rotates about an axis of rotation (14a), an acceleration sensor (88) for determining imbalances of the rotational unit (19), and a control and evaluation unit (90), which evaluates the data of the sensors (80, 82, 88), wherein the distance sensor (80) senses distance changes in an operative axis (36b). The invention is characterized in that the operative axis (36b) is oriented in relation to the axis of rotation (14a) in such a way that an angle between the operative axis (36b) and the axis of rotation (14a) of less than 90° including 0° results, at least in a projection onto a plane parallel to the operative axis (36b) and through the axis of rotation (14a).

A method and device for performing direct quantitative real time PCR in a crude sample, wherein said sample is subjected to a centrifugal force sufficient to separate components of the sample into a supernatant and a pellet, and wherein said at least one light source and said at least one detector are positioned so that the excitation light impinges on the sample in a position above said pellet, and said detector detects light emitted from a position above said pellet.

A centrifuge comprising a rotor having a rotational axis, at least one receptacle for a blood sample container, controller means for controlling the rotational speed of the rotor, at least one optical transmitter for transmitting an optical signal, at least one optical receiver for registering the amplitude of the optical signal, where the optical signal is configured to pass through the blood sample container where the optical receiver detects the amplitude of the optical signal when it is directed through the blood sample container, where the amplitude of the optical signal reflects the translucency of the blood sample, where the controller means is configured to discontinue the rotational movement of the rotor when the amplitude of the optical signal over time has fulfilled a predefined pattern indicating that at least the fibrin compression phase of the blood sample is started.

A centrifuge device, including a base, a rotation platform, and a lock module, is provided. The rotation platform is disposed on the base and adapted to support a rotor of a centrifugal bowl. The rotor is rotatably connected to a stator of the centrifugal bowl. The lock module includes a main body, a lock assembly, and a positioning component. The main body is disposed on the base. The lock assembly is movably connected to the main body and located above the rotation platform. The lock assembly is adapted to be operated to a first state to lock the stator and a second state to be separated from the stator. The positioning component is movably connected to the main body. The positioning component is adapted to move to a first position to position the lock assembly to the first state and a second position to release the lock assembly.

A continuous flow centrifuge bowl includes a rotatable outer body, and a top and bottom core that are rotatable with the outer body. The bottom core has a wall extending proximally from a bottom wall. The proximally extending wall is radially outward from at least a portion of the top core and, together with the top core, defines a primary separation region in which initial separation of the whole blood occurs. The bowl may also have a secondary separation region located between the top core and the outer body, and a rotary seal that couples an inlet port and two outlet ports to the outer body. The inlet port may be connected to an inlet tube that extends distally into a whole blood introduction region. Additionally, one of the outlet ports may be connected to an extraction tube that extends into a region below the bottom core.

Fluid separation chambers are provided with a central hub, with generally annular low-G and high-G walls extending about the hub to define therebetween a separation channel. A plurality of radial walls extend from the hub to the channel to define an inlet passage, two outlet passages, and a terminal wall separating an upstream end of the separation channel from a downstream end of the channel. The radius of the high-G wall is greater at the downstream end of the separation channel than at the upstream end, which may include the radius gradually increasing along a tapered section of the high-G wall. The tapered section may extend from the upstream end of the separation channel to the downstream end of the channel or along a smaller length of the channel. The radius of the low-G wall may similarly increase from the upstream end of the separation channel to the downstream end.