The present invention relates to a fluid treatment chamber with a self-cleaning rotary sight window. The proposed rotary sight window includes a stationary frame (10); a transparent stationary panel (11) attached to the stationary frame by a leak-tight joint (41); a rotary frame (20) connected to the stationary frame (10) by a rotary joint (40); a transparent rotary panel (21) attached to the rotary frame (20) by a joint, the transparent rotary panel (21) being arranged opposite and spaced apart from the transparent stationary panel (11) by an intermediate chamber (1); and a motor (30) connected to the transparent rotary panel (21) or to the rotary frame (20), wherein the joint between the transparent rotary panel (21) and the rotary frame (20) is an interference joint (43) attached by a dimensional interference fit.

The present invention relates to a fluid treatment chamber with a self-cleaning rotary sight window. The proposed rotary sight window includes a stationary frame (10); a transparent stationary panel (11) attached to the stationary frame by a leak-tight joint (41); a rotary frame (20) connected to the stationary frame (10) by a rotary joint (40); a transparent rotary panel (21) attached to the rotary frame (20) by a joint, the transparent rotary panel (21) being arranged opposite and spaced apart from the transparent stationary panel (11) by an intermediate chamber (1); and a motor (30) connected to the transparent rotary panel (21) or to the rotary frame (20), wherein the joint between the transparent rotary panel (21) and the rotary frame (20) is an interference joint (43) attached by a dimensional interference fit.

The present invention relates, in part, to methods, systems and processes for large-scale purification of mRNA using a filtering centrifuge operating at lower gravitational forces. The invention also relates to compositions of purified mRNA and uses thereof.

The present invention relates, in part, to methods, systems and processes for large-scale purification of mRNA using a filtering centrifuge operating at lower gravitational forces. The invention also relates to compositions of purified mRNA and uses thereof.

A portable centrifuge comprising a base, which includes a rotational mechanism contained within. A sequester wheel having a plurality of concentric rings, forming at least one channel and a central container. The at least one channel comprising a second volume and the central container comprising a first volume. A first cover is disposed over the sequester wheel to create a seal. A second cover is disposed over the first cover and is rotatable to engage with the rotational mechanism to initiate rotation at a predetermined RPM. The whole blood and/or other tissue is separated into its constituent components and deposited into the at least one channel and the central container. Specific volumes of the constituent components may be calculated to match or substantially match the first and second volumes for predetermined volume control and ease of access.

A portable centrifuge comprising a base, which includes a rotational mechanism contained within. A sequester wheel having a plurality of concentric rings, forming at least one channel and a central container. The at least one channel comprising a second volume and the central container comprising a first volume. A first cover is disposed over the sequester wheel to create a seal. A second cover is disposed over the first cover and is rotatable to engage with the rotational mechanism to initiate rotation at a predetermined RPM. The whole blood and/or other tissue is separated into its constituent components and deposited into the at least one channel and the central container. Specific volumes of the constituent components may be calculated to match or substantially match the first and second volumes for predetermined volume control and ease of access.

A method for operating a centrifuge device, the centrifuge device including a centrifuge having a light detector and the light source arranged such that detection of a filling material parameter is carried out in an interior of a centrifuge drum, and a software module for a plausibility check of the filling material parameter. The software module is connected to the light detector. The method for operating the centrifuge device includes illuminating a part of a surface of the filling material with the light source, receiving a light reflected from the filling material by the light detector and generating a corresponding detection signal, a plausibility check of the detection signal of the light detector by the software module, processing a plausible detection signal by the software module, and generating an output signal from the plausible detection signal by the software module.

A method for operating a centrifuge device, the centrifuge device including a centrifuge having a light detector and the light source arranged such that detection of a filling material parameter is carried out in an interior of a centrifuge drum, and a software module for a plausibility check of the filling material parameter. The software module is connected to the light detector. The method for operating the centrifuge device includes illuminating a part of a surface of the filling material with the light source, receiving a light reflected from the filling material by the light detector and generating a corresponding detection signal, a plausibility check of the detection signal of the light detector by the software module, processing a plausible detection signal by the software module, and generating an output signal from the plausible detection signal by the software module.

The present invention relates to a centrifugal force-based nanoparticle separation apparatus and method. Specifically, the present invention is based on having a low centrifugal force and a small size, and may thus separate nanovesicles unrelated to antibody specificity in a short time and without using an ultracentrifuge. Further, the present invention requires no additional professional personnel and enables accurate fluid measurement by integrating and automating all processes after sample injection, and may thus reduce the loss of nanovesicles.

The present invention relates to a centrifugal force-based nanoparticle separation apparatus and method. Specifically, the present invention is based on having a low centrifugal force and a small size, and may thus separate nanovesicles unrelated to antibody specificity in a short time and without using an ultracentrifuge. Further, the present invention requires no additional professional personnel and enables accurate fluid measurement by integrating and automating all processes after sample injection, and may thus reduce the loss of nanovesicles.