A two-vector centrifuge rotates on a central axis, while each centrifuge drum also rotates on the drum's own axis. The inside of each drum has flighting or threads to direct and force material to the bottom of the drum as the two-vector centrifuge rotates. Perforations in the top part of the drum allow liquids to be expelled from the drum, while dried, solid material is ejected though a gap in the bottom of the drum. A pair of troughs keep the ejected liquid fraction separate from the ejected solid fraction, and each fraction is removed from the centrifuge while the centrifuge is operating, allowing the centrifuge to run for extended periods without needing to be cleaned or have accumulated material removed.

A two-vector centrifuge rotates on a central axis, while each centrifuge drum also rotates on the drum's own axis. The inside of each drum has flighting or threads to direct and force material to the bottom of the drum as the two-vector centrifuge rotates. Perforations in the top part of the drum allow liquids to be expelled from the drum, while dried, solid material is ejected though a gap in the bottom of the drum. A pair of troughs keep the ejected liquid fraction separate from the ejected solid fraction, and each fraction is removed from the centrifuge while the centrifuge is operating, allowing the centrifuge to run for extended periods without needing to be cleaned or have accumulated material removed.

An apparatus may include a centrifuge bowl rotatable about its longitudinal axis, a discharge unit positioned to receive discharge fluid from the centrifuge bowl, a diverter fluid circuit in communication with the discharge unit, a measurement region of the diverter fluid circuit with a narrower diameter than a cross section of the discharge unit, and the diverter fluid circuit oriented to direct a portion of the discharge fluid from the discharge unit to the measurement region.

An apparatus may include a centrifuge bowl rotatable about its longitudinal axis, a discharge unit positioned to receive discharge fluid from the centrifuge bowl, a diverter fluid circuit in communication with the discharge unit, a measurement region of the diverter fluid circuit with a narrower diameter than a cross section of the discharge unit, and the diverter fluid circuit oriented to direct a portion of the discharge fluid from the discharge unit to the measurement region.

The present invention relates to a centrifugal force-based nanoparticle separation apparatus and method. Specifically, the present invention is based on having a low centrifugal force and a small size, and may thus separate nanovesicles unrelated to antibody specificity in a short time and without using an ultracentrifuge. Further, the present invention requires no additional professional personnel and enables accurate fluid measurement by integrating and automating all processes after sample injection, and may thus reduce the loss of nanovesicles.

The present invention relates to a centrifugal force-based nanoparticle separation apparatus and method. Specifically, the present invention is based on having a low centrifugal force and a small size, and may thus separate nanovesicles unrelated to antibody specificity in a short time and without using an ultracentrifuge. Further, the present invention requires no additional professional personnel and enables accurate fluid measurement by integrating and automating all processes after sample injection, and may thus reduce the loss of nanovesicles.

A separator (1) for removing contaminants from a liquid, the separator comprising a rotatably mounted chamber (2) arranged to rotate about an axis of rotation, and the separator further comprising an inlet (23) for liquid to enter the chamber and an outlet (33) for liquid to leave the chamber, and wherein the inlet is at a greater radial position from the axis of rotation as compared to the outlet, and further wherein the flow of liquid into the chamber arranged to cause the chamber to rotate, and a thickness of contaminant sludge cake (30) caused to accumulate on an inner wall of the chamber.

A separator (1) for removing contaminants from a liquid, the separator comprising a rotatably mounted chamber (2) arranged to rotate about an axis of rotation, and the separator further comprising an inlet (23) for liquid to enter the chamber and an outlet (33) for liquid to leave the chamber, and wherein the inlet is at a greater radial position from the axis of rotation as compared to the outlet, and further wherein the flow of liquid into the chamber arranged to cause the chamber to rotate, and a thickness of contaminant sludge cake (30) caused to accumulate on an inner wall of the chamber.

The present disclosure relates to a centrifugal separator (1), which comprises a rotatable drum (5) having a wall (50), an annular chamber (7), defined along the longitudinal axis (49) of the rotatable drum (5) and bordering the wall (50), an annular screw feeder (90) accommodated rotatably in the annular chamber (7) for moving a mixture of substances in the liquid phase and in the solid phase longitudinally through the annular chamber (7), and separation nets (100) arranged in the wall (50) of the rotatable drum (5). The separation nets (100) have meshes for filtering the solid phase from the liquid phase by rotation of the drum (5). The separation nets (100) are movable relative to the wall (50).

The present disclosure relates to a centrifugal separator (1), which comprises a rotatable drum (5) having a wall (50), an annular chamber (7), defined along the longitudinal axis (49) of the rotatable drum (5) and bordering the wall (50), an annular screw feeder (90) accommodated rotatably in the annular chamber (7) for moving a mixture of substances in the liquid phase and in the solid phase longitudinally through the annular chamber (7), and separation nets (100) arranged in the wall (50) of the rotatable drum (5). The separation nets (100) have meshes for filtering the solid phase from the liquid phase by rotation of the drum (5). The separation nets (100) are movable relative to the wall (50).