A system for removing undesirable elements from blood. The system includes a centrifuge bowl to separate the blood into components according to relative densities of the components, a pump to provide wash solution that washes the blood in the centrifuge bowl, and a controller to wash the blood in the centrifuge bowl in a first wash and remove first undesirable elements and to wash the blood in the centrifuge bowl in a second wash and remove trapped undesirable elements. The controller to further mix the blood and the wash solution in the centrifuge bowl and provide diluted blood, separate the diluted blood into concentrated blood and the wash solution, fill the centrifuge bowl with previously concentrated blood to build a buffy coat, and empty the centrifuge bowl of the concentrated blood and the previously concentrated blood after the buffy coat is reached.

A system for the continuous monitoring of wear and/or pressure within a gravity concentrator/centrifugal separator [10] is disclosed. The system may comprise a gravity concentrator/centrifugal separator [10] having a cone [30], rotor housing shell [20], and water jacket [40]. At least one detector [34] may be provided to at least one of the cone [30], rotor housing shell [20], and water jacket [40]. At least one integrated or handheld sensor [60] may be provided adjacent to portions of the gravity concentrator/centrifugal separator [10], the sensor [60] being configured to communicate (e.g., wirelessly) with the at least one detector [34] during operation of the gravity concentrator/centrifugal separator [10]. In use, the cone [30] may wear away and ultimately affect a function of the least one detector [34]. In use, pressure changes within the water jacket [40] may change and ultimately affect a function (e.g., an output signal) of the least one detector [34]. The at least one sensor [60] may be configured to monitor said function(s) of the least one detector [34]. When the at least one sensor [60] detects a change in the signal of the at least one detector [34], an operator or control system may be notified that maintenance or cone [30] replacement may be necessary; and/or an operator or control system may be notified that one or more operational inputs may need to be adjusted to obtain peak performance of the gravity concentrator/centrifugal separator [10].

A system for the continuous monitoring of wear and/or pressure within a gravity concentrator/centrifugal separator [10] is disclosed. The system may comprise a gravity concentrator/centrifugal separator [10] having a cone [30], rotor housing shell [20], and water jacket [40]. At least one detector [34] may be provided to at least one of the cone [30], rotor housing shell [20], and water jacket [40]. At least one integrated or handheld sensor [60] may be provided adjacent to portions of the gravity concentrator/centrifugal separator [10], the sensor [60] being configured to communicate (e.g., wirelessly) with the at least one detector [34] during operation of the gravity concentrator/centrifugal separator [10]. In use, the cone [30] may wear away and ultimately affect a function of the least one detector [34]. In use, pressure changes within the water jacket [40] may change and ultimately affect a function (e.g., an output signal) of the least one detector [34]. The at least one sensor [60] may be configured to monitor said function(s) of the least one detector [34]. When the at least one sensor [60] detects a change in the signal of the at least one detector [34], an operator or control system may be notified that maintenance or cone [30] replacement may be necessary; and/or an operator or control system may be notified that one or more operational inputs may need to be adjusted to obtain peak performance of the gravity concentrator/centrifugal separator [10].

A system for removing undesirable elements from blood. The system includes a centrifuge bowl to separate the blood into components according to relative densities of the components, a pump to provide wash solution that washes the blood in the centrifuge bowl, and a controller to wash the blood in the centrifuge bowl in a first wash and remove first undesirable elements and to wash the blood in the centrifuge bowl in a second wash and remove trapped undesirable elements. The controller to further mix the blood and the wash solution in the centrifuge bowl and provide diluted blood, separate the diluted blood into concentrated blood and the wash solution, fill the centrifuge bowl with previously concentrated blood to build a buffy coat, and empty the centrifuge bowl of the concentrated blood and the previously concentrated blood after the buffy coat is reached.

A funnel element having an open end and a closed pointed end configured to receive a multi-component fluid containing a solid fraction. The solid fraction can comprise cellular material that sediments toward the closed pointed end to form a cell pack. A wash fluid can be pumped through the cell pack to entrain microparticles and soluble contaminants. The wash fluid can be introduced into the funnel element below the cell pack such that the wash fluid percolates through the cell pack. The percolating wash fluid can dislodge microparticles or other contaminants trapped within the cell pack. Additional wash fluids can be added to funnel element where excess wash fluids overflow from the funnel element through the open end of the funnel element.

Disclosed herein are instruments and methods for performing both sample homogenization and sample clarification by centrifugation with a single instrument without transferring the sample to a new sample container and without removing or repositioning the sample container within the instrument. In some embodiments, the instrument may automatically perform centrifugation after homogenization. In other embodiments, the instrument may perform both homogenization and centrifugation simultaneously.

Disclosed herein are instruments and methods for performing both sample homogenization and sample clarification by centrifugation with a single instrument without transferring the sample to a new sample container and without removing or repositioning the sample container within the instrument. In some embodiments, the instrument may automatically perform centrifugation after homogenization. In other embodiments, the instrument may perform both homogenization and centrifugation simultaneously.

Devices and methods for washing a suspension of cells are provided. The devices include concentric center, intermediate, and outer compartments. The center compartment and the intermediate compartment are in communication with each other by a first valve and the intermediate and outer compartments are in communication with each other by an opening, aperture, or second valve. The methods include loading a suspension of cells into the center compartment, loading a wash solution into the intermediate compartment, and rotating the device. Centripetal force forces cells through the wash solution and into the outer compartment, where they are isolated and collected.

Devices and methods for washing a suspension of cells are provided. The devices include concentric center, intermediate, and outer compartments. The center compartment and the intermediate compartment are in communication with each other by a first valve and the intermediate and outer compartments are in communication with each other by an opening, aperture, or second valve. The methods include loading a suspension of cells into the center compartment, loading a wash solution into the intermediate compartment, and rotating the device. Centripetal force forces cells through the wash solution and into the outer compartment, where they are isolated and collected.

A solid-jacket screw centrifuge is disclosed. The centrifuge has a rotatable drum with a horizontal axis of rotation which encloses a bowl with a rotatable screw, an inlet for introducing material to be centrifuged into the bowl, at least one liquid and at least one solid discharge, where at least the solid discharge is assigned a non-rotatable housing surrounding it, at least radially bounding a discharge chamber, where the discharge chamber is designed as a drying chamber for the solid matter and has axial walls and one or more walls in the radial direction. The housing extends axially parallel to the axis of rotation at most into the conical region of the drum or the screw.