The present invention provides a compound of Formula I: wherein R is H or F; or a pharmaceutically acceptable salt thereof, and the use of compounds of Formula I for treatment of neurodegenerative diseases, such as Alzheimer's disease.

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The present invention discloses an annular cooling device for large-scale cylindrical shell, which comprises a plurality of inner jet devices and outer jet devices; the inner jet devices are arranged inside the cylindrical shell along the inner periphery; the outer jet devices are arranged outside the cylindrical shell along the outer periphery; each inner jet device and each outer jet device are oppositely arranged; the inner jet devices are used for spraying cooling medium to the inner wall of the cylindrical shell; the outer jet devices are used for spraying the cooling medium to the outer wall of the cylindrical shell; and the spray ranges of each inner jet device and each outer jet device in the axial direction of the cylindrical shell are both greater than the length of the cylindrical shell.

Provided is a round billet capable of reducing damage on a piercing plug in a method of producing a seamless metal tube with a Mannesmann process. The round billet (5), for use in a seamless metal tube, to be produced into a seamless metal tube with a Mannesmann process includes a body having a hole (6) formed in an axial direction of the body. The hole (6) includes an aperture (6a) opening at least at one end face of the round billet (5), and a tapered portion (61) continued to the aperture (6a) and having a diameter gradually increasing toward the aperture (6a).

A cooling device with variable cooling rate for treating metal materials, in particular for cooling steel sheets in plate mills, hot strip mills or thermal treatment lines, by means of a spray nozzle cooling system. The cooling device consists of at least two cooling bars one of each two cooling bars being situated on the lower side and the other on the upper side transversely to the sheet travel direction of the sheet and centrally between two roller table rollers and includes a spray nozzle cooling system with which a plurality of full jet nozzles and a plurality of full cone nozzles are associated, the full jet nozzles being arranged symmetrically to the full cone nozzles. A method for operating the cooling device according to the disclosure

A method to adjust the drawing action on a bar in a rolling and/or finishing train is provided, as well as an adjustment device associated with the train to implement the method. A metal product is made using the method.

Before the rolling of a metal strip on a finishing train, the actual width and actual temperature of portions of the metal strip are respectively detected. The portions of the metal strip are tracked while they run through the finishing train. The rolling stands are respectively assigned width controlling devices which determine the setpoint width and the actual width after the rolling in the assigned rolling stand, and a downstream additional setpoint value, by which the desired tension downstream of the assigned rolling stand is corrected in order to bring the actual width closer to the setpoint width. The downstream additional setpoint value is both taken into account in the determination of the actual width and fed to a tension controller, which sets an actual tension, in the metal strip downstream of the assigned rolling stand, in accordance with the corrected setpoint tension. Determining the downstream additional setpoint value by the difference between the setpoint width and the actual width of a portion of the metal strip.

In a tandem type cold rolling mill of a circulating oil-feeding system for continuously rolling a steel sheet by feeding a coolant serving as a rolling oil and a cooling water to each stand, an edge heater for heating both edge portions of the steel sheet to not lower than 60 C. as a steel sheet temperature at an entry side of a roll bite is arranged at an upstream side of the first stand in the cold rolling mill and a device for jetting a coolant having a concentration higher than that of the coolant fed to the firsts stand onto surfaces of both edge portions of the steel sheet is arranged between the edge heater and the first stand. The cold rolling mill can be used to roll a hard-to-roll material such as silicon or stainless steel sheet without causing an edge crack or sheet breakage in low-speed rolling.

A framework cooler (20) for cooling a steel strip (50), installed in a roller framework (11), the framework being in place of the work rolls (5) and the associated installation pieces (5a and 5b). For this purpose, the framework cooler (20) is sized such that it can be installed into the roller framework (11) through the operator-side roller stands (1) of the roller framework (11). The framework cooler (20) includes a lower water tank (21b) and an upper water tank (21a), each having a connection (22) for a coolant, and a plurality of cooling nozzles (23), or cooling tubes (23a) arranged in the depth direction (T) of the framework cooler (20) or at least one cooling slot (24) extending in the depth direction (T) of the framework cooler (20). The lower and the upper water tanks (21b and 21a) can be thereby supplied with coolant by the respective connection (22). The bottom side of the steel strip (50) can be cooled by the cooling nozzles (23) or cooling tubes (23a) or the cooling slot (24) of the lower water tank (21b). The top side of the steel strip (50) can be cooled by the cooling nozzles (23) or cooling tubes (23a) or the cooling slot (24) of the upper water tank (21a).

A method for operating an annealing furnace to anneal a metal strip provides that, initially, at least one target material property (MP.sub.Target) is specified for a point or a section of the metal strip after passing through the annealing furnace. In addition, information (E) on the metal strip is provided before or in the annealing furnace. A calculation of a target temperature distribution (T.sub.Target) and/or a target speed (V.sub.Target) of the metal strip in the annealing furnace is then carried out with the assistance of a computer-aided model as a function of the target material properties and the specified information. The target temperature distribution and/or target speed calculated in this manner is/are subsequently set in the annealing furnace in order to transfer the material property of the metal strip behind the annealing furnace to the desired target material property MP.sub.Target.

Before the rolling of a metal strip on a finishing train, the actual width and actual temperature of portions of the metal strip are respectively detected. The portions of the metal strip are tracked while they run through the finishing train. The rolling stands are respectively assigned width controlling devices which determine the setpoint width and the actual width after the rolling in the assigned rolling stand, and a downstream additional setpoint value, by which the desired tension downstream of the assigned rolling stand is corrected in order to bring the actual width closer to the setpoint width. The downstream additional setpoint value is both taken into account in the determination of the actual width and fed to a tension controller, which sets an actual tension, in the metal strip downstream of the assigned rolling stand, in accordance with the corrected setpoint tension. Determining the downstream additional setpoint value by the difference between the setpoint width and the actual width of a portion of the metal strip.