The disclosure relates to a method for manufacturing a biocompatible wire, a biocompatible wire comprising a biocompatible metallic material and a medical device comprising such wire.

The method for manufacturing a biocompatible wire comprises providing a workpiece of a biocompatible metallic material, cold working the workpiece into a wire, and annealing the wire, wherein a cold work percentage is 97 to 99%, wherein the cold working is a drawing with a die reduction per pass ratio in a range of 6 to 40%, and wherein the annealing is done in a range of 850 to 1100° C.

A method of making a medical guidewire including providing a wire having a length that includes a proximal length and a distal length. The method further includes applying cold work to the distal length and not applying cold work to the proximal length, thereby imparting to the distal length a diameter that is smaller than the proximal length diameter; and applying a reducing process to the wire whereby the proximal length is reduced to have an outer diameter that is the same as the outer diameter of the distal length. The proximal length has an inner diameter and the distal length has an inner diameter that is less than the inner diameter of the proximal length.

A catheter and guide wire assembly (10) for measurement of blood pressure in a living body, comprising: a proximal tube (11) having a distal end and a proximal end; a distal tube (12) having a distal end and a proximal end, which is connected to the distal end of the proximal tube (11); a fluid-permeable coil (13) having a distal end and a proximal end, which is connected to the distal end of the distal tube (12); a distal tip (14), in which the distal end of the fluid-permeable coil (13) is secured; and a core wire (16), which is attached in the proximal tube (11) and which extends through a portion of the proximal tube (11), the distal tube (12) and the fluid-permeable coil (13), and is secured in the distal tip (14), wherein the distal end of the proximal tube (11) and the proximal end of the distal tube (12) are connected by a butt joint and wherein the core wire (16) is glued or brazed to the inner wall of the proximal tube (11) at or close to the butt joint.

A method for forming a desired bend angle in an orthodontic appliance comprising: monitoring bending of the orthodontic appliance in a gripped state, the monitoring being continuous; in response to an initial bend angle in the orthodontic appliance in the gripped state being reached, causing the release of at least a portion of the orthodontic appliance so that orthodontic appliance is in a free state, measuring resultant angle of the bend in the free state; in response to resultant angle being within a predefined tolerance of the desired bend angle, determining that desired bend angle has been reached.

A mold is used to form a solder joint to join the distal end of the guidewire to a wire coil. The mold has a cavity that can have different configurations so that the solder joint can be any of bullet shaped, micro-J shaped, cone shaped, truncated cone shaped, or have a textured surface.

An occlusive device, occlusive device delivery system, method of using, and method of delivering an occlusive device, and method of making an occlusive device to treat various intravascular conditions is described.

Cutting devices useful for cutting objects or materials are described. Examples of cutting devices useful for creating avulsions in animals, such as human beings, are described. A cutting device includes an elongate main body having proximal and distal ends. A first portion of the main body has a cross-sectional shape that substantially lacks flat surfaces and a second portion of the main body has a cross-sectional shape having one, two or more flat surfaces. The distal end defines a hook having one or more sharpened edges disposed within the notch of the hook. Methods of making cutting devices are also described.

In one embodiment, a jig apparatus for bending a malleable tool includes a block having an upper surface and containing, a conical recess extending into the block through the upper surface of the block, defined by an elliptical directrix on the upper surface, an apex within the block, and generatrixes disposed about a central axis of the conical recess extending from the apex to the directrix, and an elongated cylindrical hole, which is sized to fit the malleable tool therein and has a longitudinal axis extending from the conical recess into the block at an oblique angle relative to the central axis of the conical recess, and angular markings disposed on the upper surface and around a circumference of the elliptical directrix.

Disclosed are example embodiments of an endovascular coil having a twisted figure 8 shape. The endovascular coil includes: a first loop; a second loop; and an inflection region where a portion of the first loop transitions into a portion of the second loop. The second loop is rotated about an axis parallel to the longitudinal axis of the first loop to create the twisted figure 8 shape. The twist adds more randomness and variability to the filling behavior of the endovascular coil. The added randomness and variability enables the twisted figure 8 coil to better fill the void of irregular-shaped aneurysms than other conventional embolic coils.

Methods are provided for the fabrication of microneedles. Microneedles fabricated according to the herein described methods will generally be constructed of multiple lengths of wire winded together, brazed and further manipulated to include a reversible engagement feature. The subject microneedles may find use in a variety of applications and, among other purposes, the reversible engagement feature of such a microneedle may by employed in implanting an implantable device into a biological tissue. Also provided are methods of inserting an implantable device into a biological tissue having an outer membrane. The subject methods may include ablating a section of the outer membrane and inserting the implantable device through the ablated section of outer membrane, including e.g., where the implantable device is inserted using a microneedle including e.g., those microneedles for which methods of fabrication are provided herein.