Disclosed is a method for manufacturing a leaktight assembly by providing a bag, a connection system including a connector adapted for mechanical connection to a complementary connector of a sterile chamber in order to establish sterile communication between the bag and the chamber, the connector including a portion for attachment to the bag, the connection system further including an overmolding molded over the attachment portion, the manufacturing method further including the steps of positioning the wall of the bag facing the overmolding at a first access opening of the bag, the attachment portion surrounding a space for passage between the bag and the chamber at the first access opening, and welding the wall of the bag onto the overmolding.

A technique is provided whereby hydrogen peroxide introduced into a working chamber containing a resin component is reduced to a low concentration in a shorter time than before. The present invention resides in a method of maintaining a sterile environment of a working chamber that contains a resin component, and includes a step (a) of introducing hydrogen peroxide into the working chamber, a step (b) of introducing air into the working chamber through a filter after completion of the step (a), a step (c) of generating ozone by irradiating the air with ultraviolet having a peak wavelength of from 160 nm to less than 200 nm upstream of the filter or inside the working chamber and introducing the ozone into the working chamber, and a step (d) of decomposing the ozone introduced into the working chamber into oxygen radicals.

The invention relates to a machine for the aseptic filling of liquids, to a method for opening and to a method for closing an opening window in a machine for the aseptic filling of liquids having an interior chamber and having an access opening in a wall of the machine which enables access to the interior chamber, wherein the access device comprises an opening window having a movable sash and a window frame which is permanently arranged in the wall, wherein there is an inflatable seal for aseptic sealing between the sash and the window frame. The invention further relates to a method for opening and closing the opening window in the machine for the aseptic filling of liquids.

The invention relates to a machine for the aseptic filling of liquids, to a method for opening and to a method for closing an opening window in a machine for the aseptic filling of liquids having an interior chamber and having an access opening in a wall of the machine which enables access to the interior chamber, wherein the access device comprises an opening window having a movable sash and a window frame which is permanently arranged in the wall, wherein there is an inflatable seal for aseptic sealing between the sash and the window frame. The invention further relates to a method for opening and closing the opening window in the machine for the aseptic filling of liquids.

A system for controlling pressure of a sealed enclosure such as a glove box or containment vessel, including: a first control circuit configured to keep a current pressure value of the sealed enclosure within an operational pressure range, and configured to isolate the sealed enclosure and to transmit a primary alarm signal in event of current pressure value reaching one or other of primary limits of a degradation range; an independent secondary safety circuit separate from the primary circuit, the secondary safety circuit configured to isolate the sealed enclosure and to transmit a secondary alarm signal when the pressure of the sealed enclosure reaches one or other of secondary limits of an alarm range.

A system for controlling pressure of a sealed enclosure such as a glove box or containment vessel, including: a first control circuit configured to keep a current pressure value of the sealed enclosure within an operational pressure range, and configured to isolate the sealed enclosure and to transmit a primary alarm signal in event of current pressure value reaching one or other of primary limits of a degradation range; an independent secondary safety circuit separate from the primary circuit, the secondary safety circuit configured to isolate the sealed enclosure and to transmit a secondary alarm signal when the pressure of the sealed enclosure reaches one or other of secondary limits of an alarm range.

A convenience kit for sterilizing and delivering liquids into the safety of a sterile environment inside a plastic bag (which can be disposed in a field environment) wherein a so sterilized liquid is dispensed into a vessel which is capped and sealed before removal from the bag. The convenience kit can be provided in a solitary format or, as a subkit combined with other associated items in a more inclusive convenience kit. In short, convenience kits made according to the present invention provide opportunity for accomplishing an aseptic liquid sterilizing transfer, a task which is commonly associated with on-hand capability of a laminar flow hood, in field environments and other areas which are remote from facilities having laminar flow hoods.

A convenience kit for sterilizing and delivering liquids into the safety of a sterile environment inside a plastic bag (which can be disposed in a field environment) wherein a so sterilized liquid is dispensed into a vessel which is capped and sealed before removal from the bag. The convenience kit can be provided in a solitary format or, as a subkit combined with other associated items in a more inclusive convenience kit. In short, convenience kits made according to the present invention provide opportunity for accomplishing an aseptic liquid sterilizing transfer, a task which is commonly associated with on-hand capability of a laminar flow hood, in field environments and other areas which are remote from facilities having laminar flow hoods.

An unpacking system for use in an apparatus for producing three-dimensional work pieces by irradiating layers of a raw material powder electromagnetic or particle radiation comprises a supporting structure which is configured to support a building chamber arrangement. The building chamber arrangement comprises a building chamber accommodating a carrier, the carrier being configured to receive a three-dimensional work piece produced from a raw material powder by an additive layering process. A lowering mechanism of the unpacking system is configured to apply a driving force to the building chamber so as to lower the building chamber relative to the carrier until a three-dimensional work piece received on the carrier can be removed from the carrier.

An unpacking system for use in an apparatus for producing three-dimensional work pieces by irradiating layers of a raw material powder electromagnetic or particle radiation comprises a supporting structure which is configured to support a building chamber arrangement. The building chamber arrangement comprises a building chamber accommodating a carrier, the carrier being configured to receive a three-dimensional work piece produced from a raw material powder by an additive layering process. A lowering mechanism of the unpacking system is configured to apply a driving force to the building chamber so as to lower the building chamber relative to the carrier until a three-dimensional work piece received on the carrier can be removed from the carrier.