A solid dose for insertion into the skin of a patient wherein the solid dose has a hollow core. There is also provided a solid dose carrier, a device, a method of manufacturing the solid dose and a method of delivering a solid dose transdermally to a human or animal.

An example system for molding a photocurable material into a planar object includes a first mold structure having a first mold surface, a second mold structure having a second mold surface, and one or more protrusions disposed along at least one of the first mold surface or the second mold surface. During operation, the system is configured to position the first and second mold structures such that the first and second mold surfaces face each other with the one or more protrusions contacting the opposite mold surface, and a volume having a total thickness variation (TTV) of 500 nm or less is defined between the first and second mold surfaces. The system is further configured to receive the photocurable material in the volume, and direct radiation at the one or more wavelengths into the volume.

A structure with improved adhesion includes projections and a backing layer, the rigidity of the backing layer being variable, and the end faces defining a common surface.

Configurable orthoses having a high degree of independent adjustability of various parameters are provided. In the example of a rehabilitation-evaluation ankle-foot orthosis (REAFO), these parameters may include calf band anteroposterior, height, width, sagittal tilt, coronal tilt, and mediolateral displacement adjustments; mediolateral displacement adjustments of a supramalleolar support; heel width/stirrup separation adjustment; and sagittal active joint resistance and neutral angle adjustments. Calf band mediolateral displacement adjustment may be provided by a lockable four-bar pivoting frame linkage of the REAFO. In one aspect, the configurable orthosis is used in conjunction with a plastically deformable precursor member to facilitate the design and manufacture of a definitive orthosis customized for a particular patient. In another aspect, the orthosis communicatively transmits limb shape data to either a positive shape receiver apparatus or a CAD/CAM apparatus, to facilitate design and manufacture of a definitive orthosis.

Configurable orthoses having a high degree of independent adjustability of various parameters are provided. In the example of a rehabilitation-evaluation ankle-foot orthosis (REAFO), these parameters may include calf band anteroposterior, height, width, sagittal tilt, coronal tilt, and mediolateral displacement adjustments; mediolateral displacement adjustments of a supramalleolar support; heel width/stirrup separation adjustment; and sagittal active joint resistance and neutral angle adjustments. Calf band mediolateral displacement adjustment may be provided by a lockable four-bar pivoting frame linkage of the REAFO. In one aspect, the configurable orthosis is used in conjunction with a plastically deformable precursor member to facilitate the design and manufacture of a definitive orthosis customized for a particular patient. In another aspect, the orthosis communicatively transmits limb shape data to either a positive shape receiver apparatus or a CAD/CAM apparatus, to facilitate design and manufacture of a definitive orthosis.

Devices, systems, and methods appropriate for use in medical training that include materials that better mimic natural human tissue are disclosed. In one aspect, multi-layer tissue simulations are provided. In another aspect, male genitalia models are provided. In another aspect, abdominal surgical wall inserts are provided. Systems and methods associated with these devices are also provided.

A waterproof gasket structure and its gasket shaping mold are provided. The gasket shaping mold includes a mold seat having a surface, and plural mold cavity ring-grooves concavely formed on the surface, each having two corresponding longitudinal groove sections. At least one longitudinal groove section has one or more inwardly bent wavy bent portions, and plural turning round corner portions are formed at the junction between the longitudinal groove section and the wavy bent portion, and each turning round corner portion has a radius equal to or greater than 6 mm. Therefore, the middle of the mold cavity ring-groove can be utilized effectively, and plural waterproof gaskets can be manufactured by the same gasket shaping mold while achieving the effects of reducing the mold volume, improving the manufacturing efficiency, and saving the manufacturing cost.

A novel cutting-edge structure and method and apparatus for manufacturing the cutting-edge structure is provided. The cutting-edge structure is comprised of naturally derived or renewable material at greater than 50% by volume fraction. In one embodiment, the naturally derived material is a cellulose nanostructure such as a cellulose nanocrystal. The cellulose nanocrystal is processed using a base or mold structure to provide a cutting edge of any shape such as linear or circular edge structures. The process includes dual cure steps to produce an optimal cutting-edge structure without shrinkage. The formed cutting-edge structure can be utilized as a razor blade as it is formed with very sharp tip and edge suitable for cutting hair. The base structure can form one or more cutting-edge structures simultaneously.

Provided are an anti-wrinkle composition, an anti-wrinkle microneedle patch and a preparation method thereof. The anti-wrinkle microneedle patch comprises a base and multiple needles, the base has an upper surface, and the needles are formed on the upper surface; wherein, a material of each needle comprises a low-molecular hyaluronic acid, a modified hyaluronic acid and a cross-linked hyaluronic acid. A weight ratio of the modified hyaluronic acid to the low-molecular hyaluronic acid is 0.1 to 4, and a weight ratio of the modified hyaluronic acid to the cross-linked hyaluronic acid is less than 30. Accordingly, the anti-wrinkle microneedle patch has effects of moisturizing the skin, elevating the thickness and the strength of the skin, and smoothing and reducing the wrinkles.

The present disclosure relates to a solid microneedle structure prepared using a water-insoluble polymer and a technique for manufacturing the same, wherein the technique can control the drug release rate of the microneedle: a rapid-release type or a sustained release type, the drug included in the microneedle may be various cosmetic or pharmaceutical active ingredients, and the microneedle can have an appropriate release rate suitable for the drug by the method of the invention.