The invention relates to a sealing device for repair of cardiac and vascular defects or tissue opening such as a patent foramen ovale (PFO) or shunt in the heart, the vascular system, etc. and particularly provides an occluder device and trans-catheter occluder delivery system. The sealing device would have improved conformity to heart anatomy and be easily deployed, repositioned, and retrieved at the opening site.

An implantable medical device includes a first component including a first material, a second component including a second material, and a fiber matrix including a plurality of fibers. The fiber matrix joins the first component to the second component. The fiber matrix includes a first a first portion connected to the first component, and a second portion connected to the second component. The first portion of the fiber matrix is interpenetrated with, and mechanically fixed to, the first material. The first portion of the fiber matrix directly contacts the first material.

An implantable medical device includes a first component including a first material, a second component including a second material, and a fiber matrix including a plurality of fibers. The fiber matrix joins the first component to the second component. The fiber matrix includes a first a first portion connected to the first component, and a second portion connected to the second component. The first portion of the fiber matrix is interpenetrated with, and mechanically fixed to, the first material. The first portion of the fiber matrix directly contacts the first material.

A guide wire for minimally invasive operations with a distal wire end piece (3, II) connected to a wire main piece (2), wherein the guide wire (I, 10) has, at least in the distal wire end piece (3, II), an inner shaft (4, 14) and at least one protective layer enclosing the inner shaft (4, 14), the inner shaft (4, 14) comprises a first fibre composite material and, at least in the distal wire end piece (3, II), the inner shaft (4, 14) has a plurality of weakened points (8, 18), which are created by mechanical interventions, is characterised in that the weakened points (8, 18) are created by buckling load, bending load and/or breaking load. Correspondingly, for a method for producing a guide wire of this kind it is proposed that the weakened points (8, 18) are created by buckling load, bending load and/or breaking load.

A guide wire for minimally invasive operations with a distal wire end piece (3, II) connected to a wire main piece (2), wherein the guide wire (I, 10) has, at least in the distal wire end piece (3, II), an inner shaft (4, 14) and at least one protective layer enclosing the inner shaft (4, 14), the inner shaft (4, 14) comprises a first fibre composite material and, at least in the distal wire end piece (3, II), the inner shaft (4, 14) has a plurality of weakened points (8, 18), which are created by mechanical interventions, is characterised in that the weakened points (8, 18) are created by buckling load, bending load and/or breaking load. Correspondingly, for a method for producing a guide wire of this kind it is proposed that the weakened points (8, 18) are created by buckling load, bending load and/or breaking load.

Methods and structures are disclosed. An example method includes: rotating a tubular mandrel about a longitudinal axis of the tubular mandrel; depositing a composite material on an inner surface of the tubular mandrel to form a composite tubular member on the inner surface of the tubular mandrel; inserting and expanding an inner expandable mandrel within the composite tubular member to cause the inner expandable mandrel to press the composite tubular member against the inner surface of the tubular mandrel; curing the composite tubular member; removing the inner expandable mandrel; placing a frame within the composite tubular member; and removing the tubular mandrel so as to obtain the composite tubular member with the frame placed therein.

Methods and structures are disclosed. An example method includes: rotating a tubular mandrel about a longitudinal axis of the tubular mandrel; depositing a composite material on an inner surface of the tubular mandrel to form a composite tubular member on the inner surface of the tubular mandrel; inserting and expanding an inner expandable mandrel within the composite tubular member to cause the inner expandable mandrel to press the composite tubular member against the inner surface of the tubular mandrel; curing the composite tubular member; removing the inner expandable mandrel; placing a frame within the composite tubular member; and removing the tubular mandrel so as to obtain the composite tubular member with the frame placed therein.

An integrated testing device and fluid module are disclosed, as well as a method of manufacture. Fluid module contains a reservoir containing a test fluid, and a control vessel. The reservoir discharges test fluid into the control vessel, which discharges the test fluid in a controlled way to a test component.

A method for producing a woven fabric comprises weaving fibers in a warp direction and a weft direction to form a fabric having a top surface and a bottom surface, wherein the warp fibers and weft fibers each comprises one or more filaments of a synthetic polymer having substantially uniform cross-sectional composition. At least a portion of the filaments in the fibers on the top and/or bottom surface of the fabric are then fused together in the presence of a heat transfer liquid or vapor added during the fusing step or added in a prior step of the fabric production process and retained by the filaments. The fusing step produces a treated fabric having a tensile strength in both the warp and weft directions of 1000 N or greater and having, in the absence of any coating, a static air permeability (SAP) of 3 l/dm.sup.2/min or lower.

A manufacturing method of a resin frame includes preparing a plurality of frame members, installing a pair of the frame members in the corner portion in a pair of molds, melting end surfaces of the pair of the frame members as welding margins, and welding the welding margins. The molds respectively includes a reference surface holding the frame members and a blade portion protruding to an inner side with respect to the reference surface. In the welding, in the corner portion, the pair of the frame members are pressed by the blade portions, so that the welding margin protrudes from between the blade portions, the outer peripheral surfaces of the pair of the frame members are bent inward, and the corner portion is made concave with respect to the portions adjacent to the corner portion.