Techniques for forming a nanopore in a lipid bilayer are described herein. In one example, an agitation stimulus level such as an electrical agitation stimulus is applied to a lipid bilayer wherein the agitation stimulus level tends to facilitate the formation of nanopores in the lipid bilayer. In some embodiments, a change in an electrical property of the lipid bilayer resulting from the formation of the nanopore in the lipid bilayer is detected, and a nanopore has formed in the lipid bilayer is determined based on the detected change in the lipid bilayer electrical property.

Techniques for forming a nanopore in a lipid bilayer are described herein. In one example, an agitation stimulus level such as an electrical agitation stimulus is applied to a lipid bilayer wherein the agitation stimulus level tends to facilitate the formation of nanopores in the lipid bilayer. In some embodiments, a change in an electrical property of the lipid bilayer resulting from the formation of the nanopore in the lipid bilayer is detected, and a nanopore has formed in the lipid bilayer is determined based on the detected change in the lipid bilayer electrical property.

A method of fabricating a polishing pad includes determining a desired distribution of voids to be introduced within a polymer matrix of a polishing layer of the polishing pad. Electronic control signals configured to be read by a 3D printer are generated which specify the locations where a polymer matrix precursor is to be deposited, and specify the locations of the desired distribution of voids where no material is to be deposited. A plurality of layers of the polymer matrix corresponding to the plurality of the first locations is successfully deposited with the 3D printer. Each layer of the plurality of layers of polymer matrix is deposited by ejecting a polymer matrix precursor from a nozzle. The polymer matrix precursor is solidified to form a solidified polymer matrix having the desired distribution of voids.

A method of fabricating a polishing pad includes determining a desired distribution of voids to be introduced within a polymer matrix of a polishing layer of the polishing pad. Electronic control signals configured to be read by a 3D printer are generated which specify the locations where a polymer matrix precursor is to be deposited, and specify the locations of the desired distribution of voids where no material is to be deposited. A plurality of layers of the polymer matrix corresponding to the plurality of the first locations is successfully deposited with the 3D printer. Each layer of the plurality of layers of polymer matrix is deposited by ejecting a polymer matrix precursor from a nozzle. The polymer matrix precursor is solidified to form a solidified polymer matrix having the desired distribution of voids.

Methods are disclosed for making articles (2) by three-dimensional printing. The methods include three-dimensional printing a build powder mixture which includes a first material powder and a second material powder to form a printed article and subsequently heating the printed article to a temperature at which a sufficient amount of the second material powder melts to enable it to infiltrate throughout the interstices between the first material powder particles so that the article (2) achieves a room temperature relative density of at least 85 percent of its theoretical density, the theoretical density being the density the article (2) would have if it contained no porosity. The first material powder has a melting temperature, melting temperature range, or dissociation temperature which is higher than the melting temperature or melting temperature range of the second material powder and the first material powder has no more than a limited amount of solubility in the second material powder.

A method of producing a metal form containing dispersed aerogel particles impregnated with polymers comprising a method of impregnating an aerogel with polymers, placing the aerogel impregnated with polymers within a dissolved polymer, cooling the dissolved polymer to create a polymer form with dispersed aerogel particles impregnated with polymers, adding molten metal to the polymer form, vaporizing the polymer form, replacing the polymer form with molten metal, and cooling the molten metal to yield a metal form containing dispersed aerogel particles impregnated with polymers. Dispersing the aerogel particles impregnated with polymers within the polymer form prior to adding molten metal allows the aerogel particles to be fully dispersed throughout the metal form.

A method of preparation of a cardo polyetherketone structural foam material, including the following steps: 1) performing a mould pressing on a cardo polyetherketone resin by a high-temperature vulcanizing machine to prepare a foaming billet; 2) placing the foaming billet in a foaming cavity of a mould-pressing machine, performing a penetration and a swelling by introducing a supercritical fluid to achieve diffusion equilibrium, forming a polymer-supercritical fluid homogeneous solution, and 3) making the polymer-supercritical fluid homogeneous solution supersaturated through a sudden release of the inner pressure of the system, thereby inducing nucleation and foaming, and finally forming a structural foam having a closed pore structure with a uniform pore size and an adjustable pore density. The production process of the present invention is clean, environmentally friendly, and has relatively high efficiency. The obtained structural foam has good mechanical properties.

A method of preparation of a cardo polyetherketone structural foam material, including the following steps: 1) performing a mould pressing on a cardo polyetherketone resin by a high-temperature vulcanizing machine to prepare a foaming billet; 2) placing the foaming billet in a foaming cavity of a mould-pressing machine, performing a penetration and a swelling by introducing a supercritical fluid to achieve diffusion equilibrium, forming a polymer-supercritical fluid homogeneous solution, and 3) making the polymer-supercritical fluid homogeneous solution supersaturated through a sudden release of the inner pressure of the system, thereby inducing nucleation and foaming, and finally forming a structural foam having a closed pore structure with a uniform pore size and an adjustable pore density. The production process of the present invention is clean, environmentally friendly, and has relatively high efficiency. The obtained structural foam has good mechanical properties.

Synthetic composite materials for use, for example, as orthopedic implants are described herein. In one example, a composite material for use as a scaffold includes a thermoplastic polymer forming a porous matrix that has continuous porosity and a plurality of pores. The porosity and the size of the pores are selectively formed during synthesis of the composite material. The example composite material also includes a plurality of a anisometric calcium phosphate particles integrally formed, embedded in, or exposed on a surface of the porous matrix. The calcium phosphate particles provide one or more of reinforcement, bioactivity, or bioresorption.

Techniques for forming a nanopore in a lipid bilayer are described herein. In one example, an agitation stimulus level such as an electrical agitation stimulus is applied to a lipid bilayer wherein the agitation stimulus level tends to facilitate the formation of nanopores in the lipid bilayer. In some embodiments, a change in an electrical property of the lipid bilayer resulting from the formation of the nanopore in the lipid bilayer is detected, and a nanopore has formed in the lipid bilayer is determined based on the detected change in the lipid bilayer electrical property.