A filling apparatus for filling a lens device with a volume of optical liquid including a dispensing system, a venting system having a vacuum pump and a vacuum chamber, a measurement system, and a lens device holding system. The dispensing system includes a source of optical liquid, a positive displacement pump, and a filling needle having a lumen in fluid communication with the source of optical liquid. The filling needle is configured to penetrate an injection zone of the lens device for filling an internal chamber of the lens device. The measurement system is configured to measure a lens zone of the lens device. The lens device holding system includes a lens fixture for maintaining a position of the lens device relative to the filling needle and the measurement system. Related systems, devices, and methods are provided.

A method (100) of forming an ocular prosthesis (13) comprising: receiving (102a) three dimensional scan data of a patients eye, the three dimensional scan data including volumetric data of at least an iris region, a pupil region and a cornea region of the eye; and forming (110) an ocular prosthesis (13) by an additive manufacturing process, the ocular prosthesis (13) having a body (15) with a volume, wherein the body of the prosthesis includes a three dimensional iris region (23), a three dimensional pupil region (25) and a three dimensional cornea region (26), and the volumetric data determines the size and shape of the iris region (23), the pupil region (25) and the cornea region (26) of the prosthesis (13).

A method (100) of forming an ocular prosthesis (13) comprising: receiving (102a) three dimensional scan data of a patients eye, the three dimensional scan data including volumetric data of at least an iris region, a pupil region and a cornea region of the eye; and forming (110) an ocular prosthesis (13) by an additive manufacturing process, the ocular prosthesis (13) having a body (15) with a volume, wherein the body of the prosthesis includes a three dimensional iris region (23), a three dimensional pupil region (25) and a three dimensional cornea region (26), and the volumetric data determines the size and shape of the iris region (23), the pupil region (25) and the cornea region (26) of the prosthesis (13).

A method for producing an accommodative intraocular lens includes providing first and second components and a support body with an interior space and open to the top, fastening the first component to the support body, generating pressure which is higher in the exterior space than in the interior space such that the first component deforms downward, producing an adhesive surface on the upper side of the first component and/or on the second component, applying a liquid to the first component from above into the latter's downwardly deformed region, the liquid at no time contacting the adhesive surface, fastening the second component to the first component with the adhesive surface, as a result of which the accommodative intraocular lens is formed and the liquid is encapsulated with the first component and the second component in a cavity arranged in the interior of the intraocular lens.

In certain embodiments, a system for making an implant for an eye comprises a laser, a camera, and a computer. The laser emits a laser beam to shape a material. The camera generates one or more images to monitor shaping of the material. The computer stores a pattern for the implant, which is designed to provide refractive treatment for the eye; sends instructions to the laser to control the laser beam to shape the material according to the pattern; assesses the images from the camera according to the pattern; and adjusts the instructions in response to the images.

Non-invasive Ocular Drug Delivery Insert Technology. The invention concerns an ocular insert which is a new biocompatible polymer-based controlled drug delivery system (CDDS) applicable to a variety of drugs and other compounds for the treatment of different ocular pathologies. This ocular insert allows releasing of at least one drug under suitable concentration levels during suitable periods of time. The device may be inserted in the lower or upper fornix conjunctiva, in a non-invasive way, meaning that the patient will be able to place the device himself, without intervention of medical specialized staff. The insert of the invention will release the drug in such a controlled rate that will allow the drug release up to 300 days by either a “Fickian” or a linear profile according to the intend purpose or pathology. The insert can be prepared with different shapes (spherical or spherical dome) and/or architectures (monolithic/layered either with or without a drug core) allowing the incorporation of at least one drug which can be released at different rates. The size, shape and design of the insert is adjusted in order to tune the drug(s) delivery profile(s) and to inhibit the risk of displacement or expulsion.

An intraocular lens (IOL) for implantation within a capsular bag of a patient's eye comprises an optical structure and a haptic structure. The optical structure comprises a planar member, a plano convex member, and a fluid optical element defined between the planar member and the plano convex member. The fluid optical element has an optical power. The haptic structure couples the planar member and the plano convex member together at a peripheral portion of the optical structure. The haptic structure comprises a fluid reservoir in fluid communication with the fluid optical element and a peripheral structure for interfacing to the lens capsule. Shape changes of the lens capsule cause one or more of volume or shape changes to the fluid optical element in correspondence to deformations in the planar member to modify the optical power of the fluid optical element.

Provided is a biodegradable ocular implant for sustained drug delivery, including a first layer comprising a first biodegradable polymer, wherein the first layer contains a drug dispersed or dissolved therein. A multi-layered biodegradable ocular implant is also disclosed.

A method of altering a refractive property of a crosslinked acrylic polymer material by irradiating the material with a high energy pulsed laser beam to change its refractive index. The method is used to alter the refractive property, and hence the optical power, of an implantable intraocular lens after implantation in the patient's eye. In some examples, the wavelength of the laser beam is in the far red and near IR range and the light is absorbed by the crosslinked acrylic polymer via two-photon absorption at high laser pulse energy. The method also includes designing laser beam scan patterns that compensate for effects of multiphone absorption such as a shift in the depth of the laser pulse absorption location, and compensate for effects caused by high laser pulse energy such as thermal lensing. The method can be used to form a Fresnel lens in the optical zone.

An accommodating intraocular lens device is provided. The accommodating intraocular lens device comprises a base assembly and a power lens. The base assembly comprises a first open end, a second end coupled to a base lens, and a haptic surrounding a central cavity. The haptic may comprise an outer periphery, an inner surface and a height between a first edge and a second edge. The power lens is configured to fit within the central cavity. The power lens may comprise a first side, a second side, a peripheral edge coupling the first and second sides, and a closed cavity configured to house a fluid. The first side of the power lens may be positioned at a predetermined distance from the first edge of the haptic.