A medical device includes an elongate body and an inflatable balloon attached to and partially surrounding at least a section of the elongate body. The inflatable balloon is selectively inflatable between a deflated state and an inflated state. Engagement between the balloon and a physiological lumen is provided, in part, by multiple protrusions extending from the inflatable balloon and having various physical and functional characteristics. In certain implementations, the balloon may be configured to exhibit various separation forces by applying different strains to the balloon, such as by varying the degree to which the balloon is inflated or deflated.

A balloon catheter assembly comprises a balloon having attached to or in its wall one or more filar elements, extending from one end of the balloon to the other. The filar elements are made of a material which is at least as flexible as the material forming the walls of the balloon. In the event of circular burst of the balloon, the filar element(s) prevent disconnection of the material of the balloon into two or more separate pieces. The filar element(s) become attached to or in the material of the balloon wall when the raw material is inflated to the shape of a mold. The filar elements may comprise a natural fiber, a synthetic fiber or a metal wire.

A balloon catheter assembly comprises a balloon having attached to or in its wall one or more filar elements, extending from one end of the balloon to the other. The filar elements are made of a material which is at least as flexible as the material forming the walls of the balloon. In the event of circular burst of the balloon, the filar element(s) prevent disconnection of the material of the balloon into two or more separate pieces. The filar element(s) become attached to or in the material of the balloon wall when the raw material is inflated to the shape of a mold. The filar elements may comprise a natural fiber, a synthetic fiber or a metal wire.

A multi-layer bladder includes: a first bladder layer; a mask including a plurality of apertures; a second bladder layer bonded to the first bladder layer within the apertures in the mask and where the mask is not present between the first and second bladder layers, where the mask is configured to prevent bonding of the second bladder layer to the first bladder layer where the mask is present; and a fluid channel that is located between the first and second bladder layers and that extends to the mask from an outer edge of the multi-layer bladder.

Described are balls, in particular a football, and a method for its manufacture. The ball comprises particles of an expanded material. As examples, the particles are connected, at least partially, to each other by radio frequency welding and/or infrared welding. As examples, the ball has a first layer of the particles of the expanded material, wherein the first layer is provided as an outer shell.

Described are balls, in particular a football, and a method for its manufacture. The ball comprises particles of an expanded material. As examples, the particles are connected, at least partially, to each other by radio frequency welding and/or infrared welding. As examples, the ball has a first layer of the particles of the expanded material, wherein the first layer is provided as an outer shell.

Various embodiments disclosed relate to drug-coated balloon catheters for treating strictures in body lumens and methods of using the same. A drug-coated balloon catheter for delivering a therapeutic agent to a target site of a body lumen stricture includes an elongated balloon having a main diameter. The balloon catheter includes a coating layer overlying an exterior surface of the balloon. The coating layer includes one or more water-soluble additives and an initial drug load of a therapeutic agent.

Various embodiments disclosed relate to drug-coated balloon catheters for treating strictures in body lumens and methods of using the same. A drug-coated balloon catheter for delivering a therapeutic agent to a target site of a body lumen stricture includes an elongated balloon having a main diameter. The balloon catheter includes a coating layer overlying an exterior surface of the balloon. The coating layer includes one or more water-soluble additives and an initial drug load of a therapeutic agent.

A method of manufacturing a seamless inflatable ball contains: 1) inflating air into a preformed body so as to form a spherical body and covering a medium layer on the spherical body so as to form a semi-finished part; 2) forming a fluidic surface material on the medium layer of the semi-finished part in a predetermined thickness so as to produce a spherical portion with a covering layer; 3) placing the spherical portion into two ball molds; and 4) partially discharging air out of the spherical body and inflating the air into the spherical body repeatedly. In the step 3), the spherical portion is clamped in the two ball molds, and after the fluidic surface material is dried or is solidified to form a solid layer on the spherical portion, the spherical portion is removed from the two ball molds, thus forming a sphere.

A method of manufacturing a seamless inflatable ball contains: 1) inflating air into a preformed body so as to form a spherical body and covering a medium layer on the spherical body so as to form a semi-finished part; 2) forming a fluidic surface material on the medium layer of the semi-finished part in a predetermined thickness so as to produce a spherical portion with a covering layer; 3) placing the spherical portion into two ball molds; and 4) partially discharging air out of the spherical body and inflating the air into the spherical body repeatedly. In the step 3), the spherical portion is clamped in the two ball molds, and after the fluidic surface material is dried or is solidified to form a solid layer on the spherical portion, the spherical portion is removed from the two ball molds, thus forming a sphere.