A package that is suitable for packaging an article for collecting or administering a pharmaceutical active substance is disclosed. The package includes a first packaging component that includes a product-contacting sealant layer that includes a first ethylene vinyl alcohol copolymer. The package includes a second packaging component that includes a product-contacting sealant layer that includes a second ethylene vinyl alcohol copolymer. The ethylene content of the second ethylene vinyl alcohol copolymer is equal to or less than about 38 percent and the ethylene content of the first ethylene vinyl alcohol copolymer is greater than the ethylene content of the second ethylene vinyl alcohol copolymer.

Disclosed are polymer vials (110, 210) and injection stretch blow molding methods for making the same. A polymer vial has a base (112) having a base surface area and a sidewall (114) extending up from the base. The base and sidewall define an interior (116) configured to house product, the sidewall narrowing at an upper section of the vial to form a neck leading to an opening that provides access to the interior. The vial is optionally round and symmetrical about a central axis, a lower portion of the sidewall including a first surface that is outwardly curved along a first radius having an imaginary center positioned within the vial. The base is positioned below the first surface and is substantially flat such that at least 80% of the base surface area has a standing base surface occupying a single plane.

There is provided a method for producing a metal-resin composite which includes a resin member and a metal member having a roughened surface in at least a portion of the surface thereof, the resin member being joined so as to be in contact with at least a portion of the roughened surface. The method includes a step of joining the resin member and the metal member by melting the resin member with the frictional heat generated in the surface of the metal member on its side opposite to the resin member in a state where the metal member and the resin member are superposed. The method includes making adjustment so that when the roughened surface is measured at arbitrary five points by using a confocal microscope according to ISO 25178, the developed area ratio (Sdr) is 5 or more in terms of number-average value.

There is provided a method for producing a metal-resin composite which includes a resin member and a metal member having a roughened surface in at least a portion of the surface thereof, the resin member being joined so as to be in contact with at least a portion of the roughened surface. The method includes a step of joining the resin member and the metal member by melting the resin member with the frictional heat generated in the surface of the metal member on its side opposite to the resin member in a state where the metal member and the resin member are superposed. The method includes making adjustment so that when the roughened surface is measured at arbitrary five points by using a confocal microscope according to ISO 25178, the developed area ratio (Sdr) is 5 or more in terms of number-average value.

The process to fabricate a polymer film includes baking a cyclic olefin copolymer (COC) and a silicon wafer at a predefined temperature. The process also includes attaching a plastic tape frame to the silicon wafer and submerging the COC and the plastic tape frame within water allowing one or more ultra-thin sheets of COC film to be peeled off.

A multi-layer film structure for use in forming blister packaging. The multi-layer structure includes a first polymeric layer having a first surface and a second surface, the first polymeric layer comprising a metalized polyethylene teraphthalate, a second polymeric layer having a first surface and a second surface, the first surface of the second polymeric layer disposed adjacent the second surface of the first polymeric layer, the second polymeric layer comprising a cyclic olefin or a homopolymer of chlorotrifluoroethylene, and a third polymeric layer having a first surface and a second surface, the first surface of the third polymeric layer disposed adjacent the second surface of the second polymeric layer, the third polymeric layer comprising polypropylene or polyvinyl chloride. A method of making a multi-layer film structure and a packaging structure are also provided.

A method for the production of an elastic laminate, comprising the following steps in a same production line: to coextrude a first web of elastic film (F) with at least three layers (F1, F2, F1), comprising at least two different polymer materials, to feed contemporaneously said coextruded first elastic film (F) web and two second nonwoven webs (T1, T2) to a thermal, binding calender (14), wherein the first elastic film web is arranged between said two second nonwoven webs when entering the calender; wherein said first elastic film web, during the movement from the coextrusion step to the thermal binding step, passes from a melted state, in the coextrusion step, to a solidified and cold state when entering the calender, to join, through spot welding in said calender, said second nonwoven webs with respective opposite outer layers of said first elastic film web, thus producing an intermediate web (P1), to stretch mechanically said intermediate web according to a direction transverse to the same web.

A method for the production of an elastic laminate, comprising the following steps in a same production line: to coextrude a first web of elastic film (F) with at least three layers (F1, F2, F1), comprising at least two different polymer materials, to feed contemporaneously said coextruded first elastic film (F) web and two second nonwoven webs (T1, T2) to a thermal, binding calender (14), wherein the first elastic film web is arranged between said two second nonwoven webs when entering the calender; wherein said first elastic film web, during the movement from the coextrusion step to the thermal binding step, passes from a melted state, in the coextrusion step, to a solidified and cold state when entering the calender, to join, through spot welding in said calender, said second nonwoven webs with respective opposite outer layers of said first elastic film web, thus producing an intermediate web (P1), to stretch mechanically said intermediate web according to a direction transverse to the same web.

Provided is a method for producing a decorated cycloolefin resin molded article, the method comprising curing a gel coat composition and polymerizing a cycloolefin polymerizable composition containing a radical generator while the gel coat composition is in contact with the cycloolefin polymerizable composition, thereby containing a decorated cycloolefin resin molded article including a gel coat and a cycloolefin resin layer adhering to each other.

Materials and methods of making have been developed for mass production of thermoplastic microfluidic chips. An elastomer diaphragm with a stress relieving feature can be used in microfluidic valves, pump diaphragms, and diaphragm micropumps. An optimized pump chamber design for complete fluid displacement and chamber geometry are provided. Microfluidic pressure regulators use a pneumatically actuated elastic membrane in a back-pressure regulator configuration. Microfluidic accumulators store pressurized fluid in a microfluidic chip. Removable caps for cell culture and a quick release top are described. Methods to incorporate hydrogels and ECM scaffolds have been developed. Electro pneumatic manifolds connect and control of multiple microfluidic devices vertically or on a rotary mechanism.