The present invention relates to a novel process for the production of novel fibre-reinforced profile materials filled with a rigid foam core, especially a PMI foam core. In particular, the present invention relates to a novel process which, in various versions, provides a particularly high throughput and allows a very wide range of shaping options. One step here continuously produces a complex fibre-reinforced profile material and simultaneously inserts the rigid foam core into same. In addition, in the same process step, very good binding of the rigid foam core to the fibre-reinforced profile material is assured. Shaping further takes place in two or more moulds simultaneously to achieve a particularly high throughput and simultaneously produce profile materials differing in shape.

In a photocurable resin composition containing a polyfunctional radically polymerizable compound (A), a monofunctional radically polymerizable compound (B), and a curing agent (D), the polyfunctional radically polymerizable compound (A) has an ethylenically unsaturated group equivalent of 700 g/eq or more and 7,000 g/eq or less, and fluororesin particles (C) are added in an amount of 5 parts or more by mass and 30 parts or less by mass based on a total of 100 parts by mass of the polyfunctional radically polymerizable compound (A) and the monofunctional radically polymerizable compound (B).

Provided is a composition including an acrylamide compound having a molecular weight of 150 or greater but 250 or less (A1), a polyfunctional polymerizable compound including an alkylene oxide group (A2), and a polyfunctional polymerizable compound (A3) different from the polyfunctional polymerizable compound (A2).

Provided is a composition including an acrylamide compound having a molecular weight of 150 or greater but 250 or less (A1), and a monomer having a cyclic structure represented by General Formula (3) below, or General Formula (4) below, or both (A2),

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where, in General Formulae (3) and (4), L is a single bond or a straight chain or branched alkylene group that has from 1 through 10 carbon atoms and may include an oxygen atom, a nitrogen atom, or a sulfur atom;

A is a cyclic structure that has from 2 through 10 carbon atoms and may include an oxygen atom, a nitrogen atom, or a sulfur atom; R.sup.6 is a hydrogen atom or a methyl group; and R.sup.7 and R.sup.8 are each a straight chain or branched alkyl group having from 1 through 10 carbon atoms.

A material that can be formed into a porous prosthetic sleeve liner that provides particularly useful benefits for prosthetics. The material is breathable and sweat-absorbing, thus minimizing skin morbidity when used as a prosthetic liner. The material can include hydrophilic-lined continuous pores within a hydrophobic polymer, wherein the hydrophilic lining is crosslinked together with the hydrophobic polymer via non-degradable covalent interactions using chain crosslinkers.

Described herein is a method for producing photochromic silicone hydrogel contact lenses in a relatively efficient and consistent manner from a polymerizable composition under a controlled thermal curing scheme. The main polymerizable components in the polymerizable composition are a high radical-reactive hydrophilic (meth)acrylamido monomer, a high radical-reactive siloxane-containing (meth)acrylamido monomer, and a polysiloxane vinylic crosslinker(s) free of low-reactive ethylenically unsaturated group as the main crosslinker. The thermal free radical initiator having a 10 hour half-life temperature (T.sub.10h?) of from about 50? C. to about 90? C. The controlled thermal curing scheme includes maintaining a first curing temperature of from about (T.sub.10h??20)? C. to about T.sub.10h?? C. for a first curing time and maintaining a second curing temperature of from about (T.sub.10h?+10)? C. to about (T.sub.10h?+35)? C. for a second curing time.

The present invention relates to a polymer composition comprising: (a) 54.0-79.0 wt % of a (meth)acrylic polymer; (b) 20.0-45.0 wt % of a copolymer comprising polymeric units according to formula (I) and polymeric units according to formula (II) and (c) 1.0-10.0 wt % of a copolymer comprising polymeric units according to formula (I) and polymeric units according to formula (III), wherein n=0 or 1; with regard to the total weight of the polymer composition. Such polymer composition provides a desired high heat resistance and good scratch resistance.

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Fluidic infiltrative assemblies of 3D hydrogel with heterogeneous compositions and functions in accordance with embodiments of the invention are disclosed. In one embodiment, a method for generating three-dimensional (3D) hydrogels is provided, the method comprising: generating a fluidic mold; infiltrating the fluidic mold with a precursor solution; gelatinizing the precursor solution; and degrading the fluidic mold in a degradation solution to release a 3D hydrogel.

Methods of synthesizing multilayer structures, including multilayer capsules, tubes and hair-covered substrates, are provided. A substrate is provided comprising a polymerization initiator. The initiator-loaded substrate is exposed to a solution comprising a monomer and crosslinker. The initiator diffuses outwardly from the substrate, thereby initiating polymerization of the monomer and forming a layered structure comprising a polymer portion disposed on an exterior surface of the substrate. The process may be repeated for a selected number of cycles, thereby forming a multilayer structure having a selected number of layers. The composition, thickness and properties of each layer are selectively controlled. Multilayer structures formed in accordance with the methodologies are also provided.

A composition comprising a plurality of cell aggregates for use in the production of engineered organotypic tissue by organ printing. A method of making a plurality of cell aggregates comprises centrifuging a cell suspension to form a pellet, extruding the pellet through an orifice, and cutting the extruded pellet into pieces. Apparatus for making cell aggregates comprises an extrusion system and a cutting system. In a method of organ printing, a plurality of cell aggregates are embedded in a polymeric or gel matrix and allowed to fuse to form a desired three-dimensional tissue structure. An intermediate product comprises at least one layer of matrix and a plurality of cell aggregates embedded therein in a predetermined pattern. Modeling methods predict the structural evolution of fusing cell aggregates for combinations of cell type, matrix, and embedding patterns to enable selection of organ printing processes parameters for use in producing an engineered tissue having a desired three-dimensional structure.