Three-dimensional printing processes are disclosed which utilize printable fluids comprising a carrier fluid, a polymeric binder, and nanoparticles. The three-dimensional printing processes are useful for making articles from a build material powder, e.g., a ceramic, metal, metal alloy, or intermetallic powder. The nanoparticles enable low temperature interparticle bonding of the build material powder particles, e.g., by forming bridging bonds between adjacent powder particles, and/or increasing the interparticle friction between the build material powder particles to enhance the structural strength of the as-built article during a thermal treatment over at least a part of the temperature range which has as its low end the temperature at which the structural strength due to the binder becomes insubstantial and as its high end the temperature at which the structural strength due to interparticle sintering of the build material powder becomes substantial, i.e., the article's debile temperature range. Green density improvements are achievable.

A method for producing a fiber-reinforced plastic combined body from a prepreg, includes: heating the prepreg in an atmosphere above a room temperature and lower than a curing temperature of the prepreg; provisionally combining pre-products obtained by the heating together or with another component; and retaining and curing the combined pre-products at the curing temperature or higher.

A medical device is disclosed, comprising a substrate and a hydrophilic surface coating arranged on said substrate. The substrate has, on its surface coated with said hydrophilic surface coating, a surface texture with an arithmetical mean deviation of the surface profile (Ra) of at least 3 m and/or a profile section height difference (Rdc (1-99%)) of at least 18 m. It has surprisingly been found that the increased surface roughness of the substrate provides significant improvements in e.g. water retention for the hydrophilic coating.

Provided herein are devices and systems for depositing a material or manufacturing a product, such as a pharmaceutical dosage form, by additive manufacturing. Further provided are methods of using the devices and systems, as well as methods of manufacturing a product, such as a pharmaceutical dosage form, by additive manufacturing. In certain embodiments, the device includes a material supply system configured to melt an pressurized a material, a pressure sensor configured to detect a pressure of the material within the device, and a control switch comprising a sealing needle operable in an open position and closed position. The sealing needle extends through a feed channel containing the material and includes a taper end, wherein the tapered end of the sealing needle engages a tapered inner surface of a nozzle to inhibit flow of the material through the nozzle when the sealing needle is in the closed position.

The present invention relates to a solid form, particularly to a 3D-printed immediate release solid dosage form (e.g. based on a pharmaceutical, nutraceutical, or food supplement composition). To overcome some of the solubility and disintegration problems inherited by 3D-printed solid dosage forms, the solid form comprises one or more channels, generally in the form of tubular passages or grooves, through the body of the solid form or the surface thereof.

Provided herein are devices and systems for depositing a material or manufacturing a product, such as a pharmaceutical dosage form, by additive manufacturing. Further provided are methods of using the devices and systems, as well as methods of manufacturing a product, such as a pharmaceutical dosage form, by additive manufacturing. In certain embodiments, the device includes a material supply system configured to melt a pressurized a material, a pressure sensor configured to detect a pressure of the material within the device, and a control switch comprising a sealing needle operable in an open position and closed position. The sealing needle extends through a feed channel containing the material and includes a taper end, wherein the tapered end of the sealing needle engages a tapered inner surface of a nozzle to inhibit flow of the material through the nozzle when the sealing needle is in the closed position.

A water-based binder solution comprises a thermoplastic binder, greater than or equal to 4 wt % to less than or equal to 20 wt % of a non-aqueous solvent having a boiling point greater than or equal to 100 C. and less than or equal to 175 C., and water. The thermoplastic binder comprises a first polymer strand having a weight average molecular weight (Mw) of from 5,000 g/mol to 15,000 g/mol; and at least one of a second polymer strand having a weight average molecular weight (Mw) of from 10,000 g/mol to 50,000 g/mol and a third polymer strand having a weight average molecular weight (Mw) of from 1,000 g/mol to 5,000 g/mol. A method of monitoring a print head of an additive manufacture process comprises depositing a water-based binder solution on the thermal paper.

Methods and apparatuses for bonding polymeric parts are disclosed. Specifically, in one embodiment, the polymeric parts are bonded by plastically deforming them against each other while they are below the glass transition temperatures. A method includes: placing a first polymeric part in contact with a second polymeric part; and plastically deforming the first polymeric part and the second polymeric part against each other to bond the first polymeric part to the second polymeric part. Additionally, during the plastic deformation, a temperature of the first polymeric part is less than a glass transition temperature of the first polymeric part and a temperature of the second polymeric part is less than a glass transition temperature of the second polymeric part.

Methods and apparatuses for bonding polymeric parts are disclosed. Specifically, in one embodiment, the polymeric parts are bonded by plastically deforming them against each other while they are below the glass transition temperatures. A method includes: placing a first polymeric part in contact with a second polymeric part; and plastically deforming the first polymeric part and the second polymeric part against each other to bond the first polymeric part to the second polymeric part. Additionally, during the plastic deformation, a temperature of the first polymeric part is less than a glass transition temperature of the first polymeric part and a temperature of the second polymeric part is less than a glass transition temperature of the second polymeric part.

The present invention generally relates to compositions comprising a binder and a metal powder, and associated methods. Some compositions provided include a polymer and a metal powder. Some compositions provided include a binder formulation and a metal powder. The binder formulation generally includes a first liquid and a polymer. The binder formulation may be a solution. The polymer may include a nitrogen-containing repeat unit. The metal powder may include a noble metal. Some methods provided include combining a metal powder with a binder formulation. Methods provided include but are not limited to additive manufacturing processes and injection molding processes.