A process for the manufacture of semi-plastic pharmaceutical unit doses using a rotary moulding machine and semi-plastic pharmaceutical dosage units obtained by this process.

The present invention relates to an extrudable polymer composition comprising: 99.5 to 99.95% of at least one hard-soft block copolymer comprising: at least 25% by weight of soft block polyethylene glycol (PEG) with functionality equal to 2, with respect to the total weight in copolymer; from 0.05 to 0.5% by weight of at least one polyol comprising at least three hydroxyl groups, with respect to the total weight of the composition; characterised in that: the weight-average molecular mass of said copolymer is at least equal to 100,000 g/mol; and the weight-average molecular mass of the polyol is at least equal to 1000 g/mol; and said at least one polyol binding hard copolymer blocks by ester bonds.
This invention relates in particular to the use of said composition in extrusion processes for manufacturing vapour-permeable objects.

The present application relates to a composition, which comprises: (a) a photopolymerizable substance; (b) a thiol; (c) a photoinitiator; (d) a thermosensitive polymer; and (e) water, and can be used as a bio-ink for preparing a bio-hydrogel for direct-writing 3D printing. The present invention further relates to a method for preparing the composition, and a direct-writing 3D printing method using the composition.

Disclosed herein are hydrogel compositions comprising a triblock copolymer having a formula A-B-A, wherein A is a polycaprolactone (PCL) block or a polyvalerolactone (PVL) block and B is a polyethylene glycol (PEG) block. Also disclosed are methods of making a hydrogel comprising providing a photoinitiator and a triblock copolymer having a formula A-B-A, wherein the triblock copolymer comprises one or more ethylenically unsaturated moieties; and photocrosslinking the triblock copolymer, thereby forming a hydrogel. Also disclosed are methods of printing a three-dimensional (3D) article comprising extruding a printing composition from a deposition nozzle moving relative to a substrate, the printing composition comprising a photoinitiator and any herein disclosed triblock copolymer, wherein the triblock copolymer comprises one or more ethylenically unsaturated moieties; depositing one or more layers comprising the printing composition on the substrate; and photocrosslinking the triblock copolymer to form the printed 3D article.

The present invention relates to pharmaceutical dosage forms, for example to a tamper resistant dosage form including an opioid analgesic, and processes of manufacture, uses, and methods of treatment thereof.

The present invention relates to pharmaceutical dosage forms, for example to a tamper resistant dosage form including an opioid analgesic, and processes of manufacture, uses, and methods of treatment thereof.

A polymer processing aid (PPA) reduces melt defects in extruded polyolefins in the absence of fluoropolymers. The polymer processing aid comprises a polyalkylene glycol such as a polyethylene glycol together with a high pressure low density polyethylene (LDPE) and reduces melt defects well in a thermoplastic polyolefin such as a linear low density polyethylene (LLDPE).

The invention describes methods for producing a biphasic nanocomposite scaffold comprising custom polymer-based core-shelled nanospheres by the physical and chemical attachment of two disparate polymeric materials whose composition can be readily modified with tissue-specific nanomaterials and products created using such methods. The custom nanospheres are constructed via co-axial wet electrospraying and can be employed to deliver compounds to the polymeric materials.

A percutaneous absorption preparation is disclosed. The percutaneous absorption preparation contains donepezil for treatment of dementia, wherein the preparation includes: (a) donepezil or its pharmaceutically acceptable salt as active component, (b) propylene glycol monocaprylate as solubilizer, and (c) styrene-isoprene-styrene block copolymer (SIS) as adhesive. The percutaneous absorption preparation has low skin irritation and high skin penetration.

The present disclosure provides compositions and methods for producing hydrogel matrix constructs. Methods of using hydrogel matrix constructs for tissue repair and regeneration and for the oxygenation of red blood cells are also disclosed.