An extended-release bio absorbable subcutaneous medicinal dosage delivery implant system includes an implant fabricated from a highly homogeneously mixed composition including a medicinal agent in combination with release controlling polymers which include poly (DL-lactide) and polycaprolactone. In one implementation for treating an opioid disease, the formulation composition includes naltrexone at 40 weight percent, poly (DL-lactide) in the range between 36 and 46.4 weight percent, and polycaprolactone in the range between 24 and 11.6 weight percent. In addition, in order to provide anti-biofouling quality and prevent foreign body adsorption/interaction with the material of the implant, polyethylene glycol is added in a preferred content of 2.0%. The manufacturing process includes hot melt extrusion and a mini jet based implant formation stage with the optimized process space were the temperature of the process ranges from 170° C.-180° C., mixing time through the HME process ranging from 8 minutes to 12 minutes, and injection time ranging from 8 seconds to 12 seconds. The resulting implants have a uniquely shaped free of defects bio absorbable solid body.

A method for preparing a sacrificial support material for use in printing a three-dimensional (3D) article includes providing a water-soluble thermoplastic polymer composite including a water-soluble thermoplastic polyethylene oxide graft polymer having a polyethylene oxide polymer backbone, and from about 0.05% to about 10% by weight of the polyethylene oxide polymer backbone of at least one polar vinyl monomer grafted to the polyethylene oxide polymer backbone. One or more nanoscopic particulate processing aids may be uniformly dispersed in the graft polymer in an amount of from about 0.05% to about 10% by weight of the water-soluble thermoplastic polymer composite. The water-soluble thermoplastic polymer composite may have a viscosity in the range of about 100 to about 10,000 Pa-sec. The method may also include forming the water-soluble thermoplastic polymer composite into the 3D printable sacrificial support material.

The present disclosure provides compositions and methods for producing hydrogel matrix constructs. Methods of using hydrogel matrix constructs for tissue repair and regeneration and for the oxygenation of red blood cells are also disclosed.

Describes are support elements for a sole of a shoe, in particular a sports shoe, a sole and a shoe with such a support element, as well as a method for the manufacture of a support element. As examples, the support element includes a first partial member formed of a first material, and a second partial member formed of a second material. The first partial member is mechanically joined to the second partial member in a connection region, wherein the connection region is configured to allow the first partial member to rotate or slide relative to the second partial member. The first partial member, the second partial member, and the connection region can be co-molded and joined together in a single fabricating step.

The present invention relates to pharmaceutical dosage forms, for example to a tamper resistant dosage form including an opioid analgesic, and processes of manufacture, uses, and methods of treatment thereof.

Methods and systems herein relate to forming an upper dental appliance chassis including at least two upper appliance button protrusions; forming a lower dental appliance chassis including at least two lower appliance button protrusions and at least two vertical displacement bite pads; injection overmolding a first thermoplastic on the upper dental appliance chassis to provide a first reformable thermoplastic layer integrated with the upper dental appliance chassis that exposes the at least two upper appliance button protrusions to form an upper dental tray; and injection overmolding a second thermoplastic on the upper dental appliance chassis to provide a second reformable thermoplastic layer integrated with the lower dental appliance chassis that exposes the at least two lower appliance button protrusions and the at least two vertical displacement bite pads to form a bottom dental tray.

The present invention provides a three-dimensional bioprinter for fabricating cellular constructs such as tissues and organs using electromagnetic radiation (EMR) at or above 405 nm. The bioprinter includes a material deposition device comprising a cartridge for receiving and holding a composition which contains biomaterial that cures after exposure to EMR. The bioprinter also includes an EMR module that emits EMR at a wavelength of about 405 nm or higher. Also provided is a bioprinter cartridge which contains cells and a material curable at a wavelength of about 405 nm or greater. The cells are present in a chamber and arc extruded through an orifice to form the cellular construct.

A composite lumen includes a braided structure infused with an impermeable elastic sealer. The braided structure has an inner diameter of 3 mm or less and a braid angle greater than 100°. The braided structure also has a wall thickness to inner diameter ratio greater than 0.02, picks per inch from between about 25 and about 135, and a number of ends between about 12 and about 48, with a braid pattern that is selected from 1×1, 2×2, or 2×1 and with an effective yarn denier (yarn denier×ply number) greater than 45.

An integrated multi-color animal chew toy and preparation process thereof, including selecting N types of rubbers used to form a product, wherein the rubbers have different colors and different hardness; selecting one type of rubber from the rubbers used to form the product, putting the rubber selected into a first mold, and performing mold forming to form a first molded product; putting part of the first molded product into a second mold, closing the second mold, and then injecting a second rubber selected from the rubbers used to form the product for mold forming to form a second molded product; putting part of the second molded product into a Nth mold, closing the Nth mold, and then injecting a Nth rubber selected from the rubbers used to form the product for mold forming, and then cooling to obtain the product completely.

A method of and apparatus for sinter forging a precursor powder to form a film may reduce or eliminate the stress in the film and may facilitate processing of continuous length of films such as ceramic films for use in batteries. The precursor powder can be provided on a substrate and is simultaneously heated and pressed in a pressing direction parallel to a thickness of the film so as to sinter and densify the precursor powder to form the film in a sinter forging area. Notably, in a plane perpendicular to the pressing direction, there are no lateral constraints on the sinter forging area or the material received therein.