Patent classifications
B29L2031/40
Cross-linkable microgel composite matrix bath for embedded bioprinting of perfusable tissue constructs
Described herein are apparatuses, systems, and methods for fabricating tissue constructs, such as by fabricating perfusable tissue constructs by embedding a sacrificial material into a composite matrix yield stress support bath. A composite matrix bath can include a microgel filler and a hydrogel precursor. An extrusion tip can be used for embedded printing of perfusable tissue constructs by disposing sacrificial material into the composite matrix bath while the extrusion tip travels along a predefined course through the composite matrix bath. This sacrificial material can be the printed tissue construct or can be removed to render the matrix bath a perfusable tissue construct. The composite matrix bath can include acellular or cell-laden hydrogels. The sacrificial material can include a salt and a physiological buffer or a non-cytotoxic porogen material. The hydrogel precursor can include at least one of gellan and gelatin. Cross-linking can be carried out chemically, thermally, enzymatically, or physically.
MICROCHANNEL SENSOR AND METHOD OF MANUFACTURING THE SAME
A microchannel sensor for detecting radiation and/or particles, the microchannel sensor comprising at least one sensor substrate, wherein said sensor substrate comprises a plurality of channels extending from a first side of the substrate to an opposite side of the substrate, wherein said channels are arranged along a channel axis which is tilted relative a normal axis of said substrate, and wherein said plurality of channels comprise a first set of channels with a first cross section and a second set of channels with a second cross section being different from said first cross section.
Low-cost 3D-printed tool with multiaxial/angular vessel orientation for microvascular anastomosis training
A ethically sound, safe, feasible, and cost-effective microsurgery practice technique that can easily be practiced by trainees having different skill levels and an adjustable device for holding and manipulating vascular tissue during microsurgery practice, especially for practicing anastomoses.
CROSS-LINKABLE MICROGEL COMPOSITE MATRIX BATH FOR EMBEDDED BIOPRINTING OF PERFUSABLE TISSUE CONSTRUCTS
Described herein are apparatuses, systems, and methods for fabricating tissue constructs, such as by fabricating perfusable tissue constructs by embedding a sacrificial material into a composite matrix yield stress support bath. A composite matrix bath can include a microgel filler and a hydrogel precursor. An extrusion tip can be used for embedded printing of perfusable tissue constructs by disposing sacrificial material into the composite matrix bath while the extrusion tip travels along a predefined course through the composite matrix bath. This sacrificial material can be the printed tissue construct or can be removed to render the matrix bath a perfusable tissue construct. The composite matrix bath can include acellular or cell-laden hydrogels. The sacrificial material can include a salt and a physiological buffer or a non-cytotoxic porogen material. The hydrogel precursor can include at least one of gellan and gelatin. Cross-linking can be carried out chemically, thermally, enzymatically, or physically.
Ultrasound probe, ultrasound diagnostic apparatus, and method for producing backing material
An ultrasound probe of the present invention has a piezoelectric element and a backing material disposed on one direction side with respect to the piezoelectric element, the backing material containing heat conductive particles. The backing material has a heat conductivity of 2.0 W/mk or more, and the content of the heat conductive particles is less than 30 vol % based on the total volume of the backing material.
Systems and methods for injection placement training
Systems and methods are disclosed for an injection training model that includes a base structure, an anatomical subassembly mechanically secured to the base, and a ballistic gel structure. The anatomical subassembly includes a first set of 3D-printed components manufactured from a first material, and a second set of 3D-printed components manufactured from a second material, wherein the first material has a greater stiffness than the second material. The ballistic gel structure encapsulates the anatomical subassembly and is transparent, repairable, and inorganic.
Cross-linkable microgel composite matrix bath for embedded bioprinting of perfusable tissue constructs
Described herein are apparatuses, systems, and methods for fabricating tissue constructs, such as by fabricating perfusable tissue constructs by embedding a sacrificial material into a composite matrix yield stress support bath. A composite matrix bath can include a microgel filler and a hydrogel precursor. An extrusion tip can be used for embedded printing of perfusable tissue constructs by disposing sacrificial material into the composite matrix bath while the extrusion tip travels along a predefined course through the composite matrix bath. This sacrificial material can be the printed tissue construct or can be removed to render the matrix bath a perfusable tissue construct. The composite matrix bath can include acellular or cell-laden hydrogels. The sacrificial material can include a salt and a physiological buffer or a non-cytotoxic porogen material. The hydrogel precursor can include at least one of gellan and gelatin. Cross-linking can be carried out chemically, thermally, enzymatically, or physically.
METHOD OF PRODUCING A TEST BODY FOR DIFFUSION TENSOR IMAGING
A method of producing a test body for diffusion tensor imaging, which comprises a plurality of channels in a structuring material, the channels preferably having a maximum cross-section of 625 μm.sup.2, wherein a virtual model of the test body is created and the virtual model is fed to a structuring device which produces the test body by means of a 3D printing-based, in particular lithography-based, structuring process, the structuring process being designed as a multiphoton lithography process, in particular as a multiphoton absorption process, in which the structuring material containing a photosensitizer or photoinitiator is irradiated in a location-selective manner, wherein the radiation is successively focused on focal points lying within the structuring material, resulting in that in each case a volume element of the material located in the focal point is subjected to a change in state by means of a photochemical reaction as a result of multiphoton absorption.
Method for selecting material of injection-molded article and method for manufacturing injection-molded article
The present application relates to a method for selecting an injection-molded article and a method for manufacturing an injection-molded article. An injection-molded article having excellent crack stability can be produced using the material selected using the described selection method without having to manufacture test articles through injection molding.
POST-MEDICAL-PROCEDURE THERAPY DEVICE MANUFACTURED BASED ON MEDICAL IMAGERY AND CUSTOMIZED INFORMATION OF PATIENT AND METHOD OF MANUFACTURING THE SAME
A post-medical-procedure therapy device includes a body part replica that is a replica of a body part of a patient that has undergone a medical procedure; and customized information provided on the body part replica, where both the body part replica and the customized information are 3D printed, and where the customized information includes a handwritten message provided to the patient after the medical procedure.