The invention relates to a sealing device for repair of cardiac and vascular defects or tissue opening such as a patent foramen ovale (PFO) or shunt in the heart, the vascular system, etc. and particularly provides an occluder device and trans-catheter occluder delivery system. The sealing device would have improved conformity to heart anatomy and be easily deployed, repositioned, and retrieved at the opening site.

The invention provides implantable drug delivery devices comprising a core comprising a polymer (or polymer blend) and one or more drugs or pharmaceutical substances, and an outer shell comprising a polymer (or polymer blend) and one or more porogen materials. The invention reduces burst release of drug. Pharmaceuticals such as triiodothyronine (T3) or ropinirole can be delivered by the devices.

A system for treating a tissue site includes a reduced-pressure source to apply reduced pressure, a manifold in fluid communication with the pressure source to provide reduced pressure to the tissue site, and a drape for adhering to the tissue site to cover the tissue site and the manifold. The drape includes an adhesive layer for sealing the drape to the tissue site to create a sealed space having the manifold therein, and a non-adhesive layer formed from a portion of the adhesive layer. A method for manufacturing a medical drape includes providing a sheet of adhesive material and treating a side of the sheet of adhesive material to form a non-adhesive layer and an adhesive layer. The method laminates a release liner adjacent the adhesive layer.

The present invention aims to provide a medical rubber stopper that is excellent in chemical resistance and airtightness while having good productivity. The present invention relates to a medical rubber stopper including: a disk-shaped head portion with a flange region; and a cylindrical leg portion protruding from the lower surface of the head portion and having a smaller diameter than the head portion, the lower surface of the flange region and the leg portion being laminated with an inert film, the lower surface of the flange region and/or the outer periphery of the leg portion being provided with an annular groove through which the base rubber is exposed.

The present invention comprises a method of shredding treated medical waste, cleaning it of all traces of biological gunk, and sorting it into separate components for recycling. To clean biological gunk from materials, all materials must be first shredded into small parts to expose the interior. The cleaning is performed by submerging the gunk coated materials into a caustic solution that breaks down and dissolves the gunk off of the materials. The caustic solution may comprise sodium hydroxide, potassium hydroxide, or a similar chemical, which is highly effective in producing a corrosive chemical that can break down blood, bone marrow, urine, unused medication, food waste, organs, tissues and any other biologic materials. After all of the biological material is removed from the cleaned materials, they are sorted into component materials, such as plastics, metals, rubbers, glass, etc.

In one embodiment, an orthodontic article is described comprising the reaction product of a polymerizable composition comprising: a) 30-70 parts by weight of monofunctional (meth)acrylate monomer, wherein a cured homopolymer of at least one monofunctional (meth)acrylate monomer has a Tg of at least 30, 35, 40, 45, 50, 55, or 60° C.; and b) urethane (meth)acrylate polymer comprising polymerized units of an aliphatic polyester diol. Also described are polymerizable compositions, as well as methods and systems for making an article utilizing 3D printing.

Anchoring devices and methods for affixing an implanted lead of a neurostimulation system at a target location in a patient are provided herein. Such anchoring devices includes a helical body having a plurality of tines extending laterally outward from the lead when deployed that engage tissue to inhibit axial movement of the implanted lead. The plurality of tines are biased towards the laterally extended deployed configuration and fold inward towards the lead to a delivery configuration to facilitate delivery of the lead through a sheath. The tines may be angled in a proximal direction or in both proximal and distal directions and may include various features to assist in visualization and delivery of the lead. The anchor may be formed according to various methods, including laser cutting of a tubular section along with heat or reflow to set the material with the anchor in the deployed configuration and injection molding.

The present invention relates to the amorphous form of a MALT1 inhibitor, methods of preparation thereof and pharmaceutical compositions comprising this amorphous form.

An imaging medical device includes a shaft main body portion having an image acquiring lumen and a guide wire lumen. The shaft main body portion includes a first shaft proximal portion in which the image acquiring lumen is disposed, and a second shaft proximal portion in which the guide wire lumen is disposed, with the two being bifurcated. First and second hub portions are interlocked with the first and second shaft proximal portions respectively, and a transducer unit is fixed to a drive shaft. Reference line X represents the axis line of the shaft main body portion, θ1 represents the inclination of the central axis of the first hub portion relative to the reference line, θ2 represents the inclination of the central axis of the second hub portion relative to the reference line, and the relationship of |θ1|>|θ2| is satisfied.

A medical device having an imaging function includes a shaft main body portion having an image acquiring lumen and a guide wire lumen extending from a distal side to a proximal side of the shaft main body portion. A proximal portion of the shaft main body includes a first shaft proximal portion in which the image acquiring lumen is disposed, and a second shaft proximal portion in which the guide wire lumen is disposed, and which are bifurcated. A shaft distal portion has a common lumen in which the image acquiring lumen and the guide wire lumen converge, a first hub portion is interlocked with the first shaft proximal portion, a second hub portion is interlocked with the second shaft proximal portion, and a hub casing collectively covers the first shaft proximal portion, the second shaft proximal portion, the first hub portion and the second hub portion.