An implantable medical device is disclosed comprising a thermoplastic composite body having anterior, first lateral, second lateral, posterior, superior, and inferior surfaces, and at least one dense portion and at least one porous portion which are integrally formed. The at least one dense portion is formed of a first thermoplastic polymer matrix that is essentially non-porous, and which is continuous through a thickness dimension from the superior surface to the inferior surface. The at least one porous portion is formed of a porous thermoplastic polymer scaffold having a second thermoplastic polymer matrix which is continuous through the thickness dimension. A method for forming the thermoplastic composite body is disclosed comprising disposing a first powder mixture in a first portion of a mold, disposing a second powder mixture in a second portion of the mold, simultaneously molding the first powder mixture and the second powder mixture, and leaching porogen.

The present disclosure provides pharmaceutical compositions prepared using an additive manufacturing process where the active pharmaceutical ingredient has been rendered into the amorphous form or prepared as an amorphous solid dispersion at a temperature below the melting point of the active pharmaceutical ingredient or the glass transition of the physical mixture or composition of the individual components. The present disclosure also provides methods of preparing these compositions by using properties such as the chamber and surface temperature and the electron laser density.

Methods and systems for digitally designing a plurality of aligners are provided. In some embodiments, a method includes receiving an intraoral scan of the patient's teeth, and generating 3D dental model of the patient's teeth using the intraoral scan. The method can include identifying a movement path to move the patient's teeth from an initial arrangement toward a target arrangement through a plurality of intermediate arrangements in accordance with a treatment plan. The method can also include identifying one or more appliance features of at least one aligner, the one or more appliance features including one or more feature regions having one or more feature thicknesses. The method can further include instructing an additive manufacturing machine to directly fabricate the at least one aligner in a layer-by-layer fashion.

The present invention relates to an adhesive and soluble adhesive bandage or patch comprising a soluble film of natural origin with high mineral content. The soluble film comprises from 20 to 90 wt % of mineral filler and wherein the mineral filler content level is higher than the polysaccharide content level. It also relates to these bandages or patches for use in cosmetics or therapy. Also, a method of making a soluble film.

A composite implant device for use in a medical application, comprising a synthetically-derived mesh that mimics particular critical aspects of a biologically-derived mesh. The composite implant device can be used for the reinforcement and reconstruction of tissues within the body and can be comprised of a majority of synthetic components and minority of naturally-derived components which mimic the structure and function of a naturally-derived mesh.

The disclosure relates to a subcutaneously implanted port device for establishing access to the vascular system of a patient requiring multiple blood treatments over an extended period of time. The systems, devices and methods disclosed herein may reduce miscannulation, promote intra-session hemostasis, and decrease the incidence of bacteremia and sepsis among other improvements and advantages. The devices include a port with a tapered seat for receiving an access tube, the first tapered seat having a proximal portion, a distal portion, and a conical section extending between the proximal portion and the distal portion; and an interface surface configured to engage a blood vessel or a vascular access catheter. The proximal portion of the tapered seat is configured to receive the access tube therethrough, and the tapered seat creates a mismatch fit with a diameter of the access tube when in use for an increase in flow during treatment.

Methods for forming an implantable layer onto a staple cartridge are disclosed.

A method of making an object by additive manufacturing includes: (a) providing an additive manufacturing apparatus including a light source; (b) providing a carrier platform having a substantially planar object adhesion surface, the adhesion surface having a plurality of elongate wash channels formed therein; (c) producing the object on the carrier platform adhesion surface with the additive manufacturing apparatus from a light polymerizable resin, the object having at least one internal cavity formed therein; then (d) washing the object on the carrier platform with a wash liquid under conditions in which the wash liquid reaches the at least one internal cavity through the wash channels; then (e) optionally, at least partially drying the object on the carrier platform by separating the same from the wash liquid, and then agitating the object on the carrier platform to drain excess wash liquid from the object; (f) optionally, further curing the object.

A design method of an orthopedic support suitable for being applied on a part of the body of a patient. The method initially provides for a step of determination of the part of the body where the orthopedic support is to be applied. Next is a step of identification of a generic 3D model relative to the part of the patient's body where the orthopedic support is to be applied. Then, there is a step of acquisition of a 3D image of the part of the patient's body and for a step of detection of biometric data of the part, and finally for a step of modeling of the generic 3D model by merging the generic 3D model with the 3D image in such a way to obtain a 3D model that is modelized based on the morphology of the part of the patient's body.

A method for producing a 3D-printed tissue substitute is disclosed, utilizing a 3D printing device including a tank including a yield stress fluid in which the material is printed, the printing material delivered by the cartridge includes polyvinyl alcohol and gelatin, the method including a step following which, after printing the material in the yield stress fluid, a printed intermediate device is solidified in the yield stress fluid by lowering the temperature of the tank. The intermediate device is removed from the tank, rinsed and dried in order to obtain the tissue substitute.