A system including a non-contact plate sensor and a processor configured to characterize a configuration of a plate based upon information received from the sensor, such as position on a press or plate quality. The processor is configured to initiate a responsive action based upon the characterized configuration. A related method includes setting pressure of a printing plate relative to an ink-receiving substrate and register of a printing plate relative to another printing plate on a press, without generating printed waste. The non-contact plate sensor measures a distance of the printing surface of the plate relative to the sensor in locations along the plate longitudinal axis to characterize a starting configuration of the plate. The plate longitudinal axis is adjusted to correspond with a desired position of the plate for exerting a desired pressure on the substrate, based upon a difference between the measured starting position and the desired position.