Methods and devices are disclosed for the imaging of a biological sample from all rotational perspectives in three-dimensional space and with multiple imaging modalities. A biological sample is positioned on an imaging stage that is capable of full 360-degree rotation in at least one of two orthogonal axes. Positioned about the stage are imaging modules enabling the recording of a series of images in multiple modalities, including reflected visible light, fluorescence, X-ray, ultrasound, and optical coherence tomography. A computer can use the images to construct three-dimensional models of the sample and to render images of the sample conveying information from one or more imaging channels. The rendered images can be displayed for an operator who can manipulate the images to present additional information or viewing angles of the sample. The image manipulation can be with touch gestures entered using a sterilizable or disposable touch pen.

A writing implement is configured to dispense material onto a work surface. The writing implement includes a body having a first end, a second end, and an inner surface. The writing implement also includes a nib coupled to the first end. The nib is configured to allow the material to be dispensed onto the work piece. The writing implement further includes a pressure regulating assembly coupled to the body. The pressure regulating assembly and the inner surface define a cavity configured to hold the material. The pressure regulating assembly is moveable relative to the body in response to a pressure change within the cavity.

A writing implement is configured to dispense material onto a work surface. The writing implement includes a body having a first end, a second end, and an inner surface. The writing implement also includes a nib coupled to the first end. The nib is configured to allow the material to be dispensed onto the work piece. The writing implement further includes a pressure regulating assembly coupled to the body. The pressure regulating assembly and the inner surface define a cavity configured to hold the material. The pressure regulating assembly is moveable relative to the body in response to a pressure change within the cavity.

A writing instrument 2 includes a pen tip mechanism 20, an ink tank 40, an ink induction mechanism 50, and a regulator mechanism 60. The ink tank 40 includes first and second ink tanks 40A and 40B. The pen tip mechanism 20 includes first and second pen tips 20A and 20B. The ink induction mechanism 50 includes first and second induction cores 50A and 50B. A regulator flow path set around the first induction core 50A and the second induction core 50B is partitioned into first and second regulator flow paths by the regulator mechanism 60. The first and second regulator flow paths are temporary accommodation spaces of inks and circulation spaces for sending air from the induction cores 50A and 50B to the ink tanks 40A and 40B.

A writing instrument 2 includes a pen tip mechanism 20, an ink tank 40, an ink induction mechanism 50, and a regulator mechanism 60. The ink tank 40 includes first and second ink tanks 40A and 40B. The pen tip mechanism 20 includes first and second pen tips 20A and 20B. The ink induction mechanism 50 includes first and second induction cores 50A and 50B. A regulator flow path set around the first induction core 50A and the second induction core 50B is partitioned into first and second regulator flow paths by the regulator mechanism 60. The first and second regulator flow paths are temporary accommodation spaces of inks and circulation spaces for sending air from the induction cores 50A and 50B to the ink tanks 40A and 40B.

Provided is a pen including an ink reservoir to store an ink; a pen tip which has a proximal end and a distal end opposite to the proximal end and applies an ink to a coating target; an ink guide to guide the ink in the ink reservoir toward the pen tip; and a holder part which has a through hole through which the pen tip is inserted and holds at least the proximal end of the pen tip while exposing the distal end of the pen tip with the pen tip inserted through the through hole. The holder part includes: an ink holding part capable of holding the ink from the ink guide and formed at least partially around a circumference of the through hole; and a first opening opening on an inner circumferential surface that defines the through hole and communicating with the ink holding part.

Provided is a pen including an ink reservoir to store an ink; a pen tip which has a proximal end and a distal end opposite to the proximal end and applies an ink to a coating target; an ink guide to guide the ink in the ink reservoir toward the pen tip; and a holder part which has a through hole through which the pen tip is inserted and holds at least the proximal end of the pen tip while exposing the distal end of the pen tip with the pen tip inserted through the through hole. The holder part includes: an ink holding part capable of holding the ink from the ink guide and formed at least partially around a circumference of the through hole; and a first opening opening on an inner circumferential surface that defines the through hole and communicating with the ink holding part.

A flexible marker includes a flexible body for gripping, and a marking implement carried at least partially within the body. The body is flexible to conform to the grip preferences of a user. The body has two parallel lateral sides and a first longitudinal end defining a central apex from which the marking implement can be extended. The body can be folded along or near a central longitudinal axis to bring together two lateral sides. The body can be folded along a first laterally extending axis in a first configuration in which the marking implement extends longitudinally beyond a second longitudinal end for use of the marking implement. The body can be folded along a second laterally extending axis in a second configuration in which the second longitudinal end extends longitudinally beyond the marking implement.

A flexible marker includes a flexible body for gripping, and a marking implement carried at least partially within the body. The body is flexible to conform to the grip preferences of a user. The body has two parallel lateral sides and a first longitudinal end defining a central apex from which the marking implement can be extended. The body can be folded along or near a central longitudinal axis to bring together two lateral sides. The body can be folded along a first laterally extending axis in a first configuration in which the marking implement extends longitudinally beyond a second longitudinal end for use of the marking implement. The body can be folded along a second laterally extending axis in a second configuration in which the second longitudinal end extends longitudinally beyond the marking implement.

A writing implement having a pen tip that can achieve excellent ink outflow performance and an increase in the effective area of a viewer portion allowing recognition of the writing direction, relative to the whole pen tip. The writing implement is a writing implement A which includes a pen tip 20 feeding ink from a writing implement body 10 and having a viewer portion through which the writing direction can be recognized, and is characterized in that the pen tip 20 is configured of, a least, a writing part 30 and a holding body 40 having a viewer portion 43, and the holding portion 40 has a sheet-shaped ink feeder 25 formed with slits or bumps on the surface and inside thereof to produce a capillary action.