A fundus imager includes a handheld housing that supports a lighting unit configured to illuminate an eye fundus. The lighting unit includes one or more light-emitting diodes. The housing further supports a camera configured to capture one or more images of the eye fundus, and a display configured to display the one or more images of the eye fundus. The fundus imager captures at least one multispectral fundus image using the camera, and displays the at least one multispectral fundus image on the display.

The present disclosure provides methods and an apparatus for imaging and analysing images of presumed protein deposits in the retina, retinal tissue or retinal structures and discloses methods differentiating or classifying these deposits and other optical signals from retinal structures into 1) whether they contain or do not contain classes, of proteins or protein deposits called amyloids or other proteins and/or protein deposits related to neurodegenerative eye and brain disease(s); 2) which type(s) of amyloid or other proteins or protein deposits they contain, as well as 3) whether the form and/or properties of the deposit are associated with a class of diseases or with one or another specific condition(s) (or disease(s)); whether or not this is a disease or class of disease associated with the retina or more generally with the nervous system, including the brain or 4) classified as associated with one or another level of severity of condition(s), or disease(s).

There is provided a medical image processing apparatus including: an association processing section configured to associate multiple medical captured images in which an observation target is imaged by each of multiple imaging devices including imaging devices in which one or both of an in-focus position and an in-focus range are different; and a compositing processing section configured to depth-composite each of a medical captured image for a right eye and a medical captured image for a left eye among the multiple medical captured images by using an associated other medical captured image.

A head mounted display includes a display layer, an array of light sources, a first optical combiner, and a second optical combiner. The array of light sources are configured to be selectively enabled to emit non-visible light to illuminate a fundus of an eye. The first optical combiner is configured to receive reflected non-visible light that is reflected by the eye, direct a first component of the reflected non-visible light to a first camera to generate an image of the eye, and pass a second component of the reflected non-visible light. The second optical combiner is configured to receive a fundus imaging light responsive to the second component of the reflected non-visible light, and to direct the fundus imaging light to a second camera to generate an image of the fundus.

A system to perform remote oculography includes light-occluding goggles configured to be worn by a patient. The light-occluding goggles include an infrared camera positioned to capture one or more first images of a first eye of the patient. The light-occluding goggles also include a display positioned such that it is viewable by a second eye of the patient. The display is configured to display a pattern for the patient to view. The light-occluding goggles also include a sensor configured to detect information regarding a position of a head of the patient. The system also includes a visible light camera configured to capture one or more second images of the patient as the patient wears the light-occluding goggles.

Apparatus and methods are described including illumination equipment (300) configured to direct light into an eye of a subject. An optical device (100) is placed inside the subjects eye, the optical device including a Fabry Perot interferometer (106) comprising at least two mirrors (162, 164), the Fabry Perot interferometer (106) being configured such that a distance between the mirrors (162, 164) varies as an intraocular parameter of the subjects eye varies. A retroreflector (140) is configured such that light that is transmitted through the Fabry Perot interferometer (106) is automatically reflected out of the subjects eye. Readout equipment (400) is configured to detect the light that is reflected out of the subjects eye. Other applications are also described.

Improved optical coherence tomography systems and methods to measure thickness of the retina are presented. The systems may be compact, handheld, provide in-home monitoring, allow the patient to measure himself or herself, and be robust enough to be dropped while still measuring the retina reliably.

A system and method are provided for obtaining a pupil response profile for a subject. The method include: obtaining scan data as frames of a pupil response over time prior to, during and after exposure to a flash of a light source; locating a candidate pupil to be measured from the scan data; image processing the scan data to obtain a set of pupil candidate measurements to generate a graph of pupil measurements against time; filtering the graph to produce a final set of pupil measurements forming a pupil response profile. The method may also include: measuring profile parameters from the pupil response profile; and using the profile parameters to determine aspects of the pupil response.

An optical device can include: an incident light polarizer positioned to receive incident light and configured to polarize incident light such that polarized incident light is directed to a cornea of a subject; at least one corneal light polarizer, wherein the at least one corneal light polarizer is positioned to receive reflected light from the cornea of the subject and polarize the reflected light to a second polarization; at least one rotating mechanism; and at least one receiver. The receiver can be at least one viewing port optically coupled with the at least one corneal light polarizer or an imaging device (e.g., optical detector). The at least one rotating mechanism is: coupled with the incident light polarizer; coupled with the at least one corneal light polarizer; or coupled with the incident light polarizer and the at least one corneal light polarizer.

A fundus camera includes an objective lens, an illumination device, an imaging lens group and an image sensor. The illumination device has a light emitting position and includes a plurality of light emitting modules and a driving element. Each light emitting module generates a corresponding illumination light, and the optical characteristics of the illumination lights are different from each other. The driving element drives one of the light emitting modules to the light emitting position of the illumination device to output an illumination light with required optical characteristics and irradiate it to a fundus through the objective lens. The imaging light reflected by the fundus passes through the objective lens and the imaging lens group to form an image on the image sensor so as to generate a fundus image. The abovementioned fundus camera has a compact structure and can switch the illumination light sources in a short time to obtain fundus images with different optical characteristics.