Examination of the structure and function of blood vessels is an important means of monitoring the health of a subject. Such examination can be important for disease diagnoses, monitoring specific physiologies over the short- or long-term, and scientific research. This disclosure describes technology and various embodiments of a system and method for imaging blood vessels and the intra-vessel blood flow, using at least laser speckle contrast imaging, with high speed so as to provide a rapid estimate of vessel-related or blood flow-related parameters.

The invention relates to a method for examining an eye of a patient by the patient themselves by means of an ophthalmological apparatus, said apparatus having front optics and an apparatus pupil. According to said method, the patient positions the ophthalmological apparatus relative to the eye, a measure of the deviation of the pupil of the eye from the apparatus pupil is determined, and a pupil correction signal is produced depending on the measure of the deviation, said pupil correction signal specifying a direction and/or a degree of the deviation and being output to the patient. The patient can use the pupil correction signal for repositioning in relation to the ophthalmological apparatus with a smaller deviation.

Disclosed are systems and methods for aligning an ophthalmic device with respect to an eye of a patient. In one disclosure, the system may include an ophthalmic device with an on-axis and an off-axis. The system may include an on-axis illuminator that emits light that is reflected by the eye of the patient to form an on-axis reflection having a center. The system may include an on-axis camera pointed along the on-axis. The system may include an off-axis illuminator that emits light that is reflected by the eye to form an off-axis reflection having a center. The system may include an off-axis camera pointed along the off-axis. The ophthalmic device may be operable to be aligned with respect to the eye of the patient when the on-axis is substantially normal to the center of the on-axis reflection and the off-axis is substantially normal to the center of the off-axis reflection.

Methods, apparatus, and systems for performing an ophthalmic diagnostic test are disclosed. In one aspect, a head-wearable device for administering an ophthalmic test to a subject can comprise a head-wearable frame for mounting the device onto the subject's head, and a light seal configured for coupling to the frame so as to isolate at least one eye of the subject from ambient light when the device is worn by the subject.

A spatially compact, lightweight positioning system for guiding an operator in positioning an ophthalmic instrument relative to an eye of a test subject has first and second light sources and an area detector spaced apart from a measurement axis of the instrument and from each other for providing positioning images which may be evaluated relative to stored calibration image information to determine current position of the instrument relative to the eye. The first and second light sources may fit within a lateral distance less than or equal to 25 mm. First and second illumination axes associated with the light sources may reside in a horizontal plane containing the measurement axis, and an observation axis of the area detector may reside in a vertical plane containing the measurement axis. The light sources and the area detector may be intersected by a plane which is normal to the measurement axis.

A device and computer program for determining the spherocylindrical refraction of an eye are disclosed. A component having adjustable optics is provided, the refractive power of which can be adjusted via a refractive power adjustment device. The spherocylindrical refraction is then determined from the adjustment of the refractive power adjustment device at different orientations of a typical direction of the optics or a typical direction of eye test characters.

Systems, methods, and computer-readable media for automatically controlling a lens to cornea standoff. Automatic lens to cornea standoff control can include an ophthalmic microscope with a lens arrangement configured for viewing images of an eye, a front lens assembly with a high diopter lens for resolving an image of a posterior portion of the eye, and a sensor to monitor a distance between the high diopter lens and a surface of the eye. Automatic lens to cornea standoff control can also include a control system for receiving distance information and an actuator for the front lens assembly back to the threshold standoff distance, past the threshold standoff distance, etc.

An ophthalmic device including a vision field testing section including a target presentation section and a vision field test optical system and configured to perform a vision field test on an examination eye, a measuring section including a measurement optical system to perform optical coherence tomography measurements on the examination eye, and a measurement unit configured to generate a tomographic image of the examination eye, an optical path combining section provided between the examination eye and the target presentation section and configured to combine a first optical path of the vision field test optical system and a second optical path of the measurement optical system, a first lens provided between the optical path combining section and the target presentation section and configured to perform diopter adjustment, a second lens provided between the optical path combining section and a position of the examination eye or the measurement unit, and employed in focus adjustment, a first driving section configured to move the first lens, a second driving section configured to move the second lens, and a control section configured to control the first driving section and the second driving section.

Examination of the structure and function of blood vessels is an important means of monitoring the health of a subject. Such examination can be important for disease diagnoses, monitoring specific physiologies over the short- or long-term, and scientific research. This disclosure describes technology and various embodiments of a system and method for imaging blood vessels and the intra-vessel blood flow, using at least laser speckle contrast imaging, with high speed so as to provide a rapid estimate of vessel-related or blood flow-related parameters.

An ophthalmologic apparatus comprises an optical system that acquires data of an anterior segment of a subject's eye or a fundus of the subject's eye, an imaging unit that images the anterior segment or the fundus, a movement mechanism that moves the subject's eye and the optical system relative to each other, and a controller that controls die movement mechanism. The controller controls the movement mechanism so as to maintain a positional relationship between the subject's eye and the optical system based on an anterior segment image acquired by the imaging unit in an anterior segment mode for acquiring data of the anterior segment by the optical system, and controls the movement mechanism so as to maintain the positional relationship based on a fundus image acquired by the imaging unit in a fundus mode for acquiring data of the fundus by the optical system.