An optical coherence tomography (OCT) system for imaging a retina applies a user specific focus correction to focus a sample arm light beam on the user's retina. An OCT image detector generates an OCT signal. A control unit monitors the OCT signal, controls a reference arm optical path length adjustment mechanism to identify a length of the reference arm optical path for which the OCT signal corresponds to an OCT image of the retina, and varies an operational parameter of the sample arm light beam focus mechanism over a range, while maintaining the length of the reference arm optical path for which the OCT signal corresponds to the OCT image of the retina, to identify a focus correction for the user, based on the OCT signal, for application to the sample arm light beam.

A method, system, and computer-readable medium, for detecting whether an eye blink or non-blink is captured in the image. The method includes filtering, from the image, one or more objects that are predicted to be unsuitable for determining whether an eye blink or no-blink is captured in the image, to provide a filtered image. The method also includes correlating the filtered image with a reference image, and determining, based on the correlating, whether the eye blink or non-blink is captured in the image. The eye blink is a full eye blink or a partial eye blink, and the images may be sequentially captured IR SLO images, in one example embodiment herein. Images determined to include an eye blink can be omitted from inclusion in a final (e.g., OCT) image.

A target surface in an eye is located using a dual aiming beam apparatus that transmits a first aiming beam of light and a second aiming beam of light. An optics subsystem receives a laser beam from a laser source, the first aiming beam of light, and the second aiming beam of light, and directs the beams of light to be incident with the target surface and aligns the beams of light such that they intersect at a point corresponding to a focus of the laser beam. An imaging apparatus captures an image of the target surface including a first spot corresponding to the first aiming beam of light and a second spot corresponding to a second aiming beam of light. A separation between the spots indicates that the focus is away from the target surface, while overlapping spots indicate the focus is at or on the target surface.

An optical coherence tomography (OCT) engine includes a digital Fourier-Transform (dFT) spectrometer, a tunable delay line, and a high-speed optical phased array (OPA) scanner integrated onto a single chip. The broadband dFT spectrometer offers superior signal-to-noise ratio (SNR) and fine axial resolution; the tunable delay line ensures large imaging depth by circumventing sensitivity roll-off; and the OPA can scan the beams at GHz rates without moving parts. Unlike conventional spectrometers, the dFT spectrometer employs an optical switch network to retrieve spectral information in an exponentially scaling fashion—its performance doubles with every new optical switch added to the network. Moreover, it also benefits from the Fellgett's advantage, which provide a significant SNR edge over conventional spectrometers. The tunable delay line balances the path length difference between the reference and sample arms, avoiding any need to sample high-frequency spectral fringes.

Disclosed is an eye examination apparatus that can be used in professional settings. The eye examination apparatus has a body having a first eye opening and a second eye opening for a user to see into the eye examination apparatus using two eyes. The eye examination apparatus also has a first camera coupled to the body and positioned to acquire ophthalmic images through the first eye opening, and a second camera coupled to the body and positioned to acquire ophthalmic images through the second eye opening. The eye examination apparatus also has at least one display coupled to the body and positioned to be viewable through the first eye opening and the second eye opening.

A diagnosis method includes: (a) checking tear film break-up time point and location by photographing cornea of the subject's eye and checking in time series at least one or more times of the tear film break-up time point; (b) checking corneal surface temperature by measuring the surface temperature of the cornea of the subject to be evaluated using a thermal imaging camera performed simultaneously with the photographing of the tear film of the eye; (c) mapping the tear film break-up time point and the change in the surface temperature of the cornea based on time; and (d) diagnosing type of dry eye syndrome based on any one of the tear film break-up time point and a location of surface temperature change time point of the corneal corresponding thereto, in mapping result in step (c).

An ophthalmic apparatus includes an illumination optical system including a slit in which a slit-shaped aperture is formed and an iris aperture in which two apertures are formed at positions away from an optical axis position, the iris aperture being arranged at a position substantially conjugate optically to an iris of a subject's eye between a light source and the slit, and configured to generate slit-shaped illumination light using light from the light source and to guide the illumination light to a fundus of the subject's eye; and an imaging optical system including an imaging aperture in which an aperture is formed, and configured to guide returning light of the illumination light to an image sensor, the returning light being guided from the fundus by pupil division and passing through the aperture formed in the imaging aperture. A width of the slit-shaped aperture, a distance between the two apertures, and a size of the aperture in the imaging aperture are set so that an overlap region of a light flux region of the illumination light and a light flux region of the returning light is located on a side of the fundus from a posterior surface of lens of the subject's eye within the eye of the subject eye.

The disclosed embodiments relate to multimodal imaging system comprising a fiber-coupled fluorescence imaging system, which operates based on ultra-violet (UV) excitation light, and a fiber-coupled optical coherence tomography (OCT) imaging system. The multimodal imaging system also includes a fiber optic interface comprising a single optical fiber, which facilitates light delivery to a sample-of-interest and collection of returned optical signals for both the fluorescence imaging system and the OCT imaging system. During operation of the system, the single optical fiber carries both UV light and coherent infrared light through two concentric light-guiding regions, thereby facilitating generation of precisely co-registered optical data from the fluorescence imaging system and the OCT imaging system.

The disclosed embodiments relate to multimodal imaging system comprising a fiber-coupled fluorescence imaging system, which operates based on ultra-violet (UV) excitation light, and a fiber-coupled optical coherence tomography (OCT) imaging system. The multimodal imaging system also includes a fiber optic interface comprising a single optical fiber, which facilitates light delivery to a sample-of-interest and collection of returned optical signals for both the fluorescence imaging system and the OCT imaging system. During operation of the system, the single optical fiber carries both UV light and coherent infrared light through two concentric light-guiding regions, thereby facilitating generation of precisely co-registered optical data from the fluorescence imaging system and the OCT imaging system.

A microscopy imaging system comprises a fluorescence lifetime imaging microscopy (FLIM) system comprising a pulsed light source configured to direct a plurality of excitation light pulses onto a sample, a photo detector configured to detect emitted fluorescent photons created by the plurality of excitation pulses interacting with the sample, and a FLIM data acquisition system configured to measure the time interval between the excitation light pulses and the detected emitted fluorescent photons, a scanning light microscopy (SLM) system comprising a SLM data acquisition system, a fast scanning mirror and a slow scanning mirror, wherein the mirrors are configured to scan the light pulses across the sample; and a data processing system communicatively connected to the FLIM and SLM systems. Microscopy imaging methods are also disclosed.