An apparatus for generating a metabolism model may include a processor configured to obtain a predetermined number of bio-information profiles from a bio-sensor, extract a representative bio-information profile from the obtained predetermined number of bio-information profiles, and generate the metabolism model for correcting an error of the bio-sensor by using the extracted representative bio-information profile.

The present disclosure relates to a device, method and system for calculating, estimating, or monitoring the blood pressure of a subject based on physiological features and personalized models. At least one processor, when executing instructions, may perform one or more of the following operations. A first signal representing a pulse wave relating to heart activity of a subject may be received. A plurality of second signals representing time-varying information on a pulse wave of the subject may be received. A personalized model for the subject may be designated. Effective physiological features of the subject based on the plurality of second signals may be determined. A blood pressure of the subject based on the effective physiological features and the designated model for the subject may be calculated.

Medical devices, systems and methods are provided. One method involves obtaining fabrication process measurement data for a plurality of instances of a sensing element, obtaining reference output measurement data from the plurality of instances in response to a reference stimulus, determining a predictive model for a measurement output of the sensing element as a function of fabrication process measurement variables based on the relationship between the fabrication process measurement data and the reference output measurement data, generating a simulated output measurement distribution across a range of the fabrication process measurement variables using the predictive model, identifying performance thresholds for the measurement output based on the simulated output measurement distribution, obtaining output measurement data from the instance of the sensing element in response to the reference stimulus, and verifying the output measurement data satisfies the performance threshold prior to calibrating a subsequent instance of the sensing element.

A method of protecting an in-vivo sensor includes forming a sensing surface on a surface of the in-vivo sensor, the sensing surface including a functionalized monolayer that will bind to an analyte of interest; and coating the sensing surface of the sensor with a bioabsorbable polymeric coating including a bioabsorbable polymer; wherein the bioabsorbable polymeric coating is configured to protect the in-vivo sensor until needed for implantation.

Introduced here are health management platforms able to monitor changes in the health state of a subject based on the context of digital activities performed by, or involving, the subject. Initially, a health management platform can identify a physiological response by examining physiological data associated with a subject. Then, the health management platform can identify a stimulus presented by an electronic device that provoked the physiological response by examining contextual data associated with the subject. The contextual data may be in the form of a screenshot of a computer program in use by the subject during the physiological response. In some embodiments, the health management platform prompts the subject to specify whether the physiological response is a positive physiological response that resulted in an upward shift in health or a negative physiological response that resulted in a downward shift in health.

An apparatus for monitoring nutrition, especially fermentation in a rumen of a ruminant, is designed to be orally applied to the ruminant and to stay permanently in the rumen. The apparatus includes: a) at least one sensing unit for sensing a characteristic value of dissolved carbon dioxide in the liquor of rumen and/or reticulum; and b) at least one first communication unit for the wireless communication of data with a respective second communication unit outside the ruminant. The sensing unit includes at least one attenuated total reflectance (ATR) sensor.

The disclosure relates to two methods to modify microneedles and needles to transform them as electrochemical sensors for ions and biomolecules. The methods focus on microneedles and needles made of any material through an external and internal modification methods to provide the function as electrodes: the working electrode, (pseudo)counter electrode and/or (pseudo)reference electrode depending on the electrochemical readout. With the external modification method, any solid microneedle and needle can be individually transformed in either of the said electrodes. With the internal modification method, any hollow microneedle and needle can be individually transformed in either of the electrodes. The working electrode, (pseudo)counter electrode and or (pseudo)reference electrode can be simultaneously integrated into the same hollow microneedle or needle by internal compartmentation. Two different biofluids can be simultaneously targeted by microneedles and needles of different sizes, structures and fabricated by one or both methods when integrated in the same skin patch.

A method for deriving physiological parameters may include: measuring a glucose level of a subject over time; measuring a HbA1c of individual red blood cells in a sample comprising a plurality of red blood cells; deriving a measured cellular HbA1c distribution of the sample; and calculating at least one physiological parameter selected from the group consisting of (a) a red blood cell elimination constant (k.sub.age), (b) a red blood cell glycation rate constant (k.sub.gly), and/or (c) an apparent glycation constant (K) based on the measured cellular HbA1c distribution and the glucose levels of the subject over time.

An antenna includes a controllable conductive material that is used to form transmit and/or receive antennas in different, controllable shapes. The controllable conductive material can be manipulated by an actuation control to form a continuous shape from one electrode to another to form the antenna. The controllable conductive material can be formed into multiple antennae each having a continuous shape extending between different electrodes. The antenna can be used for transmitting and receiving electromagnetic signals for determining the presence and/or amount of one or more analytes.

Dysglycemia as a risk factor for neurodevelopmental disorder or developmental diabetes. The risk is assessed based on measurement of a glucose control indicator in a blood sample. One particular example of a neurodevelopmental disorder is retinopathy of prematurity in an infant. One particular example of a glucose control indicator is ‘comprehensive glycated hemoglobin fraction’ or ‘comprehensive glycated albumin fraction.’ This is calculated using ‘total whole blood protein’ in the denominator. In the case of chronic hyperglycemia, there is an increased risk of proliferative retinopathy of prematurity. In the case of chronic hypoglycemia, there is an increased risk of non-proliferative retinopathy of prematurity. This ‘total whole blood protein’ technique could also be used to determine the glucose control status in other types of patients.