A system for determining and visualizing damage to an anatomical joint of a patient. The system is to: obtain a three dimensional image representation of an anatomical joint which is based on a medical image stack; determine damage to an anatomical structure in the anatomical joint by analyzing the medical image stack; mark damage to the anatomical structures in the obtained three dimensional image representation; obtain a 3D model based on the three dimensional image representation; and create a graphical user interface (GUI). The GUI may comprise: functionality to visualize and enable manipulation of the at least one 3D model; functionality to enable removal of the visualization of the anatomical structure from the 3D model; functionality to visualize and enable browsing of the medical image stack; and functionality to visualize the position of the medical image that is currently visualized.

The present invention relates to navigating in bronchial pathways. In order to provide further improved navigation guidance, a sequence of 2D X-ray images of a region of interest of a bronchial structure with an intrathoracic device (visible in the X-ray images) inserted in a bronchial pathway is provided. The intrathoracic device is tracked in the 2D X- ray images and direction and magnitude of repetitory cardiovascular and respiratory induced motion is assessed based on the tracked intrathoracic device. The assessed motion is modelled and a navigation information indicative of a range of the modelled motion is generated. The navigation information is shown as a confidence reference (310), for example a rEBUS historical trajectory confidence reference, to a user operating the intrathoracic device. As an example, an augmented fluoroscopy 2D image (302) of a thorax region is registered and shown overlaid with segmentation (304) of the bronchial structure and target lesion (312). Further, a confidence reference (314) of the current position of the rEBUS catheter may also be shown.

Disclosed herein is an apparatus suitable for radiation detection. The apparatus may comprise a radiation absorption layer and a first electrode on the radiation absorption layer. The radiation absorption layer may be configured to generate charge carriers therein from a radiation particle absorbed by the radiation absorption layer. The first electrode may be configured to generate an electric field in the radiation absorption layer. The first electrode may have a geometry shaping the electric field so that the electric field in an amplification region of the radiation absorption layer has a field strength sufficient to cause an avalanche of the charge carriers in the amplification region.

Systems and method for destroying or inhibiting cancer cells and other rapidly-dividing cells include applying AP magnetic fields having a defined frequency of 5 Hz-500 kHz and a field strength of 0.1-5000 μT to a target body area that includes the cancer or other rapidly-dividing cells, and modifying the cancer or tumor microenvironment to increase the presence of cancer-suppressive cells or decrease the presence of cancer-promoting cells. In various embodiments, the systems and methods may include adjusting the therapy based on the dosage of an immunotherapy drug administered to the patient before, during, or after the application of the AP magnetic fields.

A kinetic analysis system includes: an analytical value calculation unit configured to divide, into a plurality of divisions, a lung field region included in kinetic images in a plurality of time phases acquired as a result of kymography of a chest of an object, and calculate analytical values of the respective divisions in the plurality of time phases based on at least one of pixel signal values and the number of pixels in the respective divisions; a ventilation state calculation unit configured to calculate index values representing ventilation states of the respective divisions from the analytical values of the respective divisions in the plurality of time phases using different functions corresponding to the respective divisions; a display unit; and a control unit configured to cause the display unit to display the index values representing the ventilation states of the respective divisions in the plurality of time phases.

A dynamic analysis system includes: an analytic value calculation unit configured to calculate an analytic value in a plurality of time phases on the basis of a dynamic image in the plurality of time phases obtained by performing dynamic photography on the chest of a subject; a ventilation state calculation unit configured to calculate, using a non-linear function, an index value representing a ventilation state of a lung field from the analytic value in the plurality of time phases; a display unit; and a control unit configured to display the index value calculated on the plurality of time phases, on the display unit.

The invention relates to a method for obtaining useful data about the angiogenesis in a patient's lower limbs, and particularly in the lower limbs of patients with diabetes subjected to treatment.

A false positive removal engine is provided. The false positive removal engine receives detected objects in one or more images. A machine learning classifier computer model, configured with first operational parameters to implement a first operating point, processes the received input to classify each detected object as being a true positive or a false positive to generate a first set of object classifications. If the first set is empty, the false positive removal engine outputs the first set as a filtered list of objects; otherwise the ML classifier computer model is configured with second operational parameters to implement a second operating point, different from the first operating point, which then processes the received input to classify each detected object and generate a second set of objects classified as true positive, which is output by the false positive removal engine as the filtered list of objects.

Certain aspects relate to biopsy apparatuses, systems and techniques for biopsy using a biopsy pattern. Some aspects relate to moving a distal portion of a medical instrument to one or more sample locations of the biopsy pattern and guiding the instrument to obtain tissue samples from the sample locations within the biopsy pattern. Some aspects relate to obtaining the biopsy pattern and adjusting the sample locations within the biopsy pattern based on various factors such as anatomical features.

Methods and systems for navigating to a target through a patient's bronchial tree are disclosed including a bronchoscope, a probe insertable into a working channel of the bronchoscope and including a location sensor, and a workstation in operative communication with the probe and the bronchoscope, the workstation including a user interface that guides a user through a navigation plan and is configured to present a central navigation view including a plurality of views configured for assisting the user in navigating the bronchoscope through central airways of the patient's bronchial tree toward the target, a peripheral navigation view including a plurality of views configured for assisting the user in navigating the probe through peripheral airways of the patient's bronchial tree to the target, and a target alignment view including a plurality of views configured for assisting the user in aligning a distal tip of the probe with the target.