A method (20) and device for deriving an estimate of intracranial blood pressure based on motion data for a wall of an intracranial blood vessel, intracranial blood flow velocity, and a blood pressure signal measured at a location outside the brain. The method is based on identifying (28) a time offset between the two intracranial signals (vessel wall movement and vessel blood flow), and then applying (30) this offset to the blood pressure signal acquired from outside the brain to obtain a fourth signal, indicative of estimated intracranial blood pressure.

A method (20) and device for deriving an estimate of intracranial blood pressure based on motion data for a wall of an intracranial blood vessel, intracranial blood flow velocity, and a blood pressure signal measured at a location outside the brain. The method is based on identifying (28) a time offset between the two intracranial signals (vessel wall movement and vessel blood flow), and then applying (30) this offset to the blood pressure signal acquired from outside the brain to obtain a fourth signal, indicative of estimated intracranial blood pressure.

Various embodiments enable calibrating a non-invasive blood pressure measurement device by determining multiple parameters defining a stress-strain relationship of an artery of a patient. The device may obtain output signals from a blood pressure sensor at two or more measurement elevations. The obtained measurement signals may be filtered into AC and quasi-DC components, and results fit to exponential functions to calculate an arterial time constant and a veinous time constant related to vein draining/filling rates. The arterial and veinous time constants may be used to calculate an infinity ratio. The infinity ratio and the obtained sensor output may be used to calculate values for multiple parameters defining a stress-strain relationship of a measured artery. Once defined, this stress-strain relationship may be stored and applied to future sensor output signals (e.g., blood pressure measuring sessions) to infer patient blood pressure.

Various embodiments enable calibrating a non-invasive blood pressure measurement device by determining multiple parameters defining a stress-strain relationship of an artery of a patient. The device may obtain output signals from a blood pressure sensor at two or more measurement elevations. The obtained measurement signals may be filtered into AC and quasi-DC components, and results fit to exponential functions to calculate an arterial time constant and a veinous time constant related to vein draining/filling rates. The arterial and veinous time constants may be used to calculate an infinity ratio. The infinity ratio and the obtained sensor output may be used to calculate values for multiple parameters defining a stress-strain relationship of a measured artery. Once defined, this stress-strain relationship may be stored and applied to future sensor output signals (e.g., blood pressure measuring sessions) to infer patient blood pressure.

Medical devices, medical systems, and related methods are provided which may be used in detecting and treating anomalies in a vessel (e.g., in an artery). In one embodiment, a guidewire is provide with multiple sensors spaced apart from one another in a desired spacing. The sensors may each be configured to simultaneously detect a pressure within the vessel at their individual location within a single, common heartbeat of a patient. In one embodiment, information from the sensors may be mapped with other data or information (e.g., imaging data) to assist a healthcare professional in determining if interventional treatment is desired and, if so, what treatment may be most effective.

In an embodiment, a data processing method comprises receiving, from a portable physiological measuring device configured for temporary attachment to a human body, data representing one or more physiological metrics or parameters of the body; receiving, from one or more Doppler vascular sensors configured for temporary attachment to peripheral artery locations of the body and a portable Doppler vascular signal measuring device coupled to the Doppler vascular sensors, vascular function information for the body; inputting the data representing the physiological metrics or parameters and vascular function data, to a plurality of algorithms; analyzing and correlating the data representing the physiological metrics or parameters with the vascular function data based on the plurality of algorithms; generating and providing output records specifying one or more recommendations of response treatment, reports, animations, or figures based on the plurality of algorithms; and wherein the method is performed by one or more computing devices.

In an embodiment, a data processing method comprises receiving, from a portable physiological measuring device configured for temporary attachment to a human body, data representing one or more physiological metrics or parameters of the body; receiving, from one or more Doppler vascular sensors configured for temporary attachment to peripheral artery locations of the body and a portable Doppler vascular signal measuring device coupled to the Doppler vascular sensors, vascular function information for the body; inputting the data representing the physiological metrics or parameters and vascular function data, to a plurality of algorithms; analyzing and correlating the data representing the physiological metrics or parameters with the vascular function data based on the plurality of algorithms; generating and providing output records specifying one or more recommendations of response treatment, reports, animations, or figures based on the plurality of algorithms; and wherein the method is performed by one or more computing devices.

The embodiments herein provide a system for calibration-free cuff-less evaluation of blood pressure. The system includes an ultrasound-based arterial compliance probes and a controller unit connected to the said probe. The ultrasound transducers are configured to measure the change in arterial dimensions, pulse wave velocity, and other character traits of an arterial segment over continuous cardiac cycle, which is then used to evaluate blood pressure parameters without any calibration procedure using dedicated mathematical models. The pressure sensor/force sensor/bio-potential transducers/accelerometric sensors are configured to measure a pressure acting on a skin surface at a measurement site, an internal arterial transmural pressure level, an applied pressure or a hold-down pressure on the skin surface or an arterial site, biopotential and/or plethysmograph signal, arterial vibrations acting on the measurement site as a function of the arterial pressure and the mechanical characteristics and/or a function of the applied/hold-down pressure and/or function of external factors.

The embodiments herein provide a system for calibration-free cuff-less evaluation of blood pressure. The system includes an ultrasound-based arterial compliance probes and a controller unit connected to the said probe. The ultrasound transducers are configured to measure the change in arterial dimensions, pulse wave velocity, and other character traits of an arterial segment over continuous cardiac cycle, which is then used to evaluate blood pressure parameters without any calibration procedure using dedicated mathematical models. The pressure sensor/force sensor/bio-potential transducers/accelerometric sensors are configured to measure a pressure acting on a skin surface at a measurement site, an internal arterial transmural pressure level, an applied pressure or a hold-down pressure on the skin surface or an arterial site, biopotential and/or plethysmograph signal, arterial vibrations acting on the measurement site as a function of the arterial pressure and the mechanical characteristics and/or a function of the applied/hold-down pressure and/or function of external factors.

A clamping device for reducing blood flow in a human limb comprises a first rigid part having a first inner profile, and a second rigid part having a second inner profile generally facing the first inner profile. A coupling portion couples the first rigid part and second rigid part to each other. The first inner profile extends further away from the coupling portion than the second inner profile. The first and second inner profiles define a recess, the recess being shaped to enable the clamping device to be positioned on the human limb, and the clamping device being configured to shift between an expanded configuration and a clamped configuration. The first and second inner profiles are arranged to apply pressure against the human limb when the device is in the clamped configuration and thereby to apply pressure to blood vessels in the human limb and reduce blood flow through the blood vessels.