An ultrasonic sensing apparatus held next to a target can detect vital signs of the target. The ultrasonic sensing apparatus includes a first flexible circuit board, a transmitting layer, a readout layer, and a receiving layer. Emitting elements in the transmitting layer generate ultrasonic signals and the receiving layer receives reflected ultrasonic signals and converts the reflections into electrical signals. The emitting elements are staggered in relation to elements of the receiving layer for better resolution and accuracy. The readout layer reads the electric signals for calculating vital signs. The readout layer includes input lines and output lines and readout pixels are defined by the crossing points of input and output lines. Ultrasonic signals are generated during a first period, and the reflections are read in a second period next following. The readout layer completes one reading operation corresponding to one readout pixel during the second period.

Various embodiments enable calibrating a non-invasive blood pressure measurement device by determining multiple parameters defining a stress-strain relationship of an artery of a patient. The device may obtain output signals from a blood pressure sensor at two or more measurement elevations. The obtained measurement signals may be filtered into AC and quasi-DC components, and results fit to exponential functions to calculate an arterial time constant and a veinous time constant related to vein draining/filling rates. The arterial and veinous time constants may be used to calculate an infinity ratio. The infinity ratio and the obtained sensor output may be used to calculate values for multiple parameters defining a stress-strain relationship of a measured artery. Once defined, this stress-strain relationship may be stored and applied to future sensor output signals (e.g., blood pressure measuring sessions) to infer patient blood pressure.

Various embodiments enable calibrating a non-invasive blood pressure measurement device by determining multiple parameters defining a stress-strain relationship of an artery of a patient. The device may obtain output signals from a blood pressure sensor at two or more measurement elevations. The obtained measurement signals may be filtered into AC and quasi-DC components, and results fit to exponential functions to calculate an arterial time constant and a veinous time constant related to vein draining/filling rates. The arterial and veinous time constants may be used to calculate an infinity ratio. The infinity ratio and the obtained sensor output may be used to calculate values for multiple parameters defining a stress-strain relationship of a measured artery. Once defined, this stress-strain relationship may be stored and applied to future sensor output signals (e.g., blood pressure measuring sessions) to infer patient blood pressure.

The present disclosure relates to cardiac health assessment system for use with a handheld electronic device for assessing cardiac health of a user and a method for assessing cardiac health of a user. The disclosure further relates to systems and methods for training a machine learning model to estimate intracardiac pressure data.

The present disclosure relates to cardiac health assessment system for use with a handheld electronic device for assessing cardiac health of a user and a method for assessing cardiac health of a user. The disclosure further relates to systems and methods for training a machine learning model to estimate intracardiac pressure data.

Various embodiments include methods and devices for measuring blood pressure. Various embodiments may include receiving, from one or more arterial measurement sensors, a pulse waveform representing arterial pressure as a function of time for each pulse of a series of blood pressure pulses. The series of blood pressure pulses may be correlated to arterial distension at a measurement location of the arterial measurement sensors on a subject's body. One or more elevations of the measurement location may be received from one or more elevation sensors. At least one pulse in the series of pulses may be identified that represents a transitional pulse based on one or more characteristics of the at least one pulse. A diastolic blood pressure may be determined based on the at least one identified transitional pulse and elevation measurements that correspond to the one identified pulse.

Minimally invasive systems and methods are described for measuring pulmonary circulation information from the pulmonary arteries. A transbronchial Doppler ultrasound catheter is advanced through the airways and in the vicinity of the pulmonary artery. Doppler ultrasound energy is sent through the airway wall and across the pulmonary artery to obtain velocity information of blood flowing through the artery. The velocity information is used to compute pulmonary circulation information including but not limited to flowrate.

Minimally invasive systems and methods are described for measuring pulmonary circulation information from the pulmonary arteries. A transbronchial Doppler ultrasound catheter is advanced through the airways and in the vicinity of the pulmonary artery. Doppler ultrasound energy is sent through the airway wall and across the pulmonary artery to obtain velocity information of blood flowing through the artery. The velocity information is used to compute pulmonary circulation information including but not limited to flowrate.

A system includes a processor circuit that receives intravascular imaging data from an intravascular imaging catheter, an x-ray image from an x-ray imaging device, and intravascular pressure data from an intravascular pressure-sensing guidewire. The processor circuit correlates the intravascular imaging data and the intravascular pressure data to locations along a body lumen shown in the x-ray image. The processor circuit generates a longitudinal view of the body lumen based on the intravascular imaging data and outputs a screen display including the longitudinal view of the body lumen with an overlaid graphical representation corresponding to the intravascular pressure measurements.

Method and system for evaluating arterial pressure waves, vascular properties, as well as for diagnostic, physiological and pharmacological testing using various combinations of the following data acquisition and processing steps (some of the steps are optional): 1. Perturbing arterial pressure from its steady state. 2. Measuring the dynamics of at least one parameter related to the passage of arterial pressure waves along blood vessels. 3. Characterizing the magnitude and functional relation of changes in parameters described above in relation to changes in blood pressure during its displacement from and/or return to the steady state. 4. Classifying (comparing) the individual functional relation described above with a databank of parameters/functional relations for different states of vasomotor activity.