A system for delivering drugs or other molecules to the brain comprises an ultrasound imaging transducer configured to image structures such as the circle of Willis within a patient's head by way of a low attenuation acoustic window. The system includes a processor configured to register the ultrasound images to previously obtained images which also include the structures. The system includes ultrasound transducer elements operable to deliver ultrasound energy to a target region to cause the blood brain barrier to open. The system may include a drug delivery system that may be operated to deliver a drug to the patient in coordination with opening the blood brain barrier. Coordinates of the target region relative to the ultrasound imaging transducer are determined using registration information.

A system for visualization and quantification of ultrasound imaging data according to embodiments of the present disclosure may include a display unit, and a processor communicatively coupled to the display unit and to an ultrasound imaging apparatus for generating an image from ultrasound data representative of a bodily structure and fluid flowing within the bodily structure. The processor may be configured to estimate axial and lateral velocity components of the fluid flowing within the bodily structure, determine a plurality of flow directions within the image based on the axial and lateral velocity components, differentially encode the flow directions based on flow direction angle to generate a flow direction map, and cause the display unit to concurrently display the image including the bodily structure overlaid with the flow direction map.

A system for visualization and quantification of ultrasound imaging data according to embodiments of the present disclosure may include a display unit, and a processor communicatively coupled to the display unit and to an ultrasound imaging apparatus for generating an image from ultrasound data representative of a bodily structure and fluid flowing within the bodily structure. The processor may be configured to estimate axial and lateral velocity components of the fluid flowing within the bodily structure, determine a plurality of flow directions within the image based on the axial and lateral velocity components, differentially encode the flow directions based on flow direction angle to generate a flow direction map, and cause the display unit to concurrently display the image including the bodily structure overlaid with the flow direction map.

Disclosed are systems and methods using ultrasound to predict if a patient's cardiac stroke volume will increase with a fluid bolus. Ultrasound measures are taken before administering a fluid bolus, including measurement of the left ventricular outflow tract velocity time integral (LVOT VTI), and venous measurements of the internal jugular vein. Data collected from such ultrasound scan is then used to predict the patient's cardiac volume response in the event that a fluid bolus is administered to that patient.

An inspection apparatus includes a measurement apparatus that measures an inner diameter and a blood flow velocity in an artery from a fetus to a placenta of a pregnant woman, a calculation apparatus that calculates a Reynolds number based on the inner diameter and the blood flow velocity in the artery measured by the measurement apparatus, and a determination apparatus that determines, for a pregnant woman who is 20 weeks or more pregnant, that the fetus may be developing FGR in a case that the Reynolds number is less than a first threshold value.

An inspection apparatus includes a measurement apparatus that measures an inner diameter and a blood flow velocity in an artery from a fetus to a placenta of a pregnant woman, a calculation apparatus that calculates a Reynolds number based on the inner diameter and the blood flow velocity in the artery measured by the measurement apparatus, and a determination apparatus that determines, for a pregnant woman who is 20 weeks or more pregnant, that the fetus may be developing FGR in a case that the Reynolds number is less than a first threshold value.

An apparatus includes a processing pipeline with a stationary structure motion corrector, a stationary structure remover and a flowing structure detector. The stationary structure motion corrector is configured to motion correct stationary structure in a series of ultrasound images for subject motion, wherein the series of ultrasound images includes the stationary structure and flowing structure. The stationary structure remover is configured to remove the stationary structure from the motion corrected series of ultrasound images thereby producing flow images of the flowing structure. The flowing structure detector is configured to detect peaks of flow of the flowing structure in the flow images over time to generate images of detected flow peaks. The images of detected flow peaks are accumulated over time to generate a high resolution ultrasound image.

An apparatus includes a processing pipeline with a stationary structure motion corrector, a stationary structure remover and a flowing structure detector. The stationary structure motion corrector is configured to motion correct stationary structure in a series of ultrasound images for subject motion, wherein the series of ultrasound images includes the stationary structure and flowing structure. The stationary structure remover is configured to remove the stationary structure from the motion corrected series of ultrasound images thereby producing flow images of the flowing structure. The flowing structure detector is configured to detect peaks of flow of the flowing structure in the flow images over time to generate images of detected flow peaks. The images of detected flow peaks are accumulated over time to generate a high resolution ultrasound image.

There is provided a tissue elasticity measurement device 100 and a measurement method that allow for quantitative evaluation of biological changes related to tissue elasticity such as liver fibrosis. The tissue elasticity measurement device 100 has a supersonic wave measuring instrument 100a that measures a pulse waveform corresponding to a blood flow velocity by a pulse wave Doppler method, and an information processor 100b that calculates a deviation index value corresponding to a coefficient of variation from a pulse waveform obtained by the supersonic wave measuring instrument 100a.

There is provided a tissue elasticity measurement device 100 and a measurement method that allow for quantitative evaluation of biological changes related to tissue elasticity such as liver fibrosis. The tissue elasticity measurement device 100 has a supersonic wave measuring instrument 100a that measures a pulse waveform corresponding to a blood flow velocity by a pulse wave Doppler method, and an information processor 100b that calculates a deviation index value corresponding to a coefficient of variation from a pulse waveform obtained by the supersonic wave measuring instrument 100a.