Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.

Systems and methods are disclosed for identifying anatomically relevant blood flow characteristics in a patient. One method includes: receiving, in an electronic storage medium, a patient-specific representation of at least a portion of vasculature of the patient having a lesion at one or more points; receiving values for one or more metrics of interest associated with one or more locations in the vasculature of the patient; receiving one or more observed lumen measurements of the vasculature of the patient; determining the location of a diseased region in the vasculature of the patient using the received values for the one or more metrics of interest, wherein the determination of the location includes predicting or receiving one or more healthy lumen measurements of the vasculature of the patient; determining the extent of the diseased region; and generating a visualization of at least the diseased region.

Systems and methods are disclosed for identifying anatomically relevant blood flow characteristics in a patient. One method includes: receiving, in an electronic storage medium, a patient-specific representation of at least a portion of vasculature of the patient having a lesion at one or more points; receiving values for one or more metrics of interest associated with one or more locations in the vasculature of the patient; receiving one or more observed lumen measurements of the vasculature of the patient; determining the location of a diseased region in the vasculature of the patient using the received values for the one or more metrics of interest, wherein the determination of the location includes predicting or receiving one or more healthy lumen measurements of the vasculature of the patient; determining the extent of the diseased region; and generating a visualization of at least the diseased region.

An information processing device including: a control unit configured to: acquire at least one frame image generated by using line data indicating intensity of a reflection wave with respect to an ultrasound radially transmitted from an ultrasound transducer moving inside a biological tissue, and extract a specific region from the at least one frame image based on a ratio between an average of luminance in a region of interest included in the at least one frame image and a dispersion of luminance in the region of interest.

An information processing device including: a control unit configured to: acquire at least one frame image generated by using line data indicating intensity of a reflection wave with respect to an ultrasound radially transmitted from an ultrasound transducer moving inside a biological tissue, and extract a specific region from the at least one frame image based on a ratio between an average of luminance in a region of interest included in the at least one frame image and a dispersion of luminance in the region of interest.

An intraluminal sensing system is provided, which includes an intraluminal device. The intraluminal device includes a flexible elongate member that can be positioned within a body lumen of a patient, and an ultrasound sensor at a distal portion of the flexible elongate member and configured to emit an ultrasound pulse in a longitudinal direction and to receive ultrasound echoes from the pulse. The system also includes a processor circuit in communication with the ultrasound sensor. The processor circuit is configured to compute a velocity spectrum of particles moving within the body lumen based on the received ultrasound echoes and, based on the velocity spectrum, compute a skew index indicative of a position or alignment of the ultrasound sensor within the body lumen. The processor circuit is also configured to output an indication of the skew index.

An intraluminal sensing system is provided, which includes an intraluminal device. The intraluminal device includes a flexible elongate member that can be positioned within a body lumen of a patient, and an ultrasound sensor at a distal portion of the flexible elongate member and configured to emit an ultrasound pulse in a longitudinal direction and to receive ultrasound echoes from the pulse. The system also includes a processor circuit in communication with the ultrasound sensor. The processor circuit is configured to compute a velocity spectrum of particles moving within the body lumen based on the received ultrasound echoes and, based on the velocity spectrum, compute a skew index indicative of a position or alignment of the ultrasound sensor within the body lumen. The processor circuit is also configured to output an indication of the skew index.

An intraluminal sensing system is provided that includes an intraluminal device. The intraluminal device has a flexible elongate member configured to be positioned within a body lumen of a patient, and an ultrasound sensor at a distal portion of the flexible elongate member. The ultrasound sensor is configured to emit an ultrasound pulse in a longitudinal within the body lumen, and to receive Doppler-shifted echoes from the ultrasound pulse. A processor circuit in communication with the ultrasound sensor is configured to: compute a velocity spectrum of particles moving within the body lumen based on the Doppler-shifted echoes; identify features in the velocity spectrum indicative of a lateral position or angular alignment of the ultrasound sensor within the body lumen; and output, to a display in communication with the processor circuit, positioning guidance for the intraluminal device based on the identified features in the velocity spectrum.

An intraluminal sensing system is provided that includes an intraluminal device. The intraluminal device has a flexible elongate member configured to be positioned within a body lumen of a patient, and an ultrasound sensor at a distal portion of the flexible elongate member. The ultrasound sensor is configured to emit an ultrasound pulse in a longitudinal within the body lumen, and to receive Doppler-shifted echoes from the ultrasound pulse. A processor circuit in communication with the ultrasound sensor is configured to: compute a velocity spectrum of particles moving within the body lumen based on the Doppler-shifted echoes; identify features in the velocity spectrum indicative of a lateral position or angular alignment of the ultrasound sensor within the body lumen; and output, to a display in communication with the processor circuit, positioning guidance for the intraluminal device based on the identified features in the velocity spectrum.