Systems and methods for imaging a target feature of a subject based on the tracked positions of the subject and the target feature are disclosed. According to an aspect, a system includes a scanner configured to image a target feature of a subject. The system includes a mechanism configured to move the scanner. Further, the system includes a subject tracker configured to track positioning of the subject. The system includes a feature tracker configured to track positioning of the target feature. A controller is configured to control the mechanism to move the feature tracker to a position such that the feature tracker is operable to track a position of the target feature. The controller controls the mechanism to move the scanner to a position such that the scanner is operable to image the target feature based on the tracked position of the target feature by the feature tracker.

The present disclosure is directed to a method and apparatus for holding an eyelid open and preventing involuntary blinking during an ultrasound imaging procedure while ensuring patient safety and comfort. Eyelids can be taped up to the forehead or down to the cheek with common medical tape; however, this does not provide the instrument operator with the ability to adjust or control the amount of eye lid opening very well, nor allow the patient to relax the eyelids between scanning sessions. The present disclosure includes a speculum that can be placed in an eye piece such as used in a precision ultrasound device or other imaging device wherein the optical acoustic and transmission path between the eye and instrument is formed by a fluid such as saline solution and distilled water.

The present disclosure is directed to a method and apparatus for holding an eyelid open and preventing involuntary blinking during an ultrasound imaging procedure while ensuring patient safety and comfort. Eyelids can be taped up to the forehead or down to the cheek with common medical tape; however, this does not provide the instrument operator with the ability to adjust or control the amount of eye lid opening very well, nor allow the patient to relax the eyelids between scanning sessions. The present disclosure includes a speculum that can be placed in an eye piece such as used in a precision ultrasound device or other imaging device wherein the optical acoustic and transmission path between the eye and instrument is formed by a fluid such as saline solution and distilled water.

Devices and method for determining a pupil size of a subject having closed eyelids.

Devices and method for determining a pupil size of a subject having closed eyelids.

A method to apply a nerve inhibiting cloud surrounding a blood vessel includes creating a treatment plan, wherein the treatment plan prescribes application of the nerve inhibiting cloud towards at least a majority portion of a circumference of a blood vessel wall, and applying the nerve inhibiting cloud towards the majority portion of the circumference of the blood vessel wall for a time sufficient to inhibit a function of a nerve that surrounds the blood vessel wall.

An excitation force (internal or external) and phase-sensitive optical coherence elastography (OCE) system, used in conjunction with a data analyzing algorithm, is capable of measuring and quantifying biomechanical parameters of tissues in situ and in vivo. The method was approbated and demonstrated on an example of the system that combines a pulsed ultrasound system capable of producing an acoustic radiation force on the crystalline lens surface and a phase-sensitive optical coherence tomography (OCT) system for measuring the lens displacement caused by the acoustic radiation force. The method allows noninvasive and nondestructive quantification of tissue mechanical properties. The noninvasive measurement method also utilizes phase-stabilized swept source optical coherence elastography (PhS-SSOCE) to distinguish between tissue stiffness, such as that attributable to disease, and effects on measured stiffness that result from external factors, such as pressure applied to the tissue. Preferably, the method is used to detect tissue stiffness and to evaluate the presence of its stiffness even if it is affected by other factors such as intraocular pressure (TOP) in the case of cornea, sclera, or the lens. This noninvasive method can evaluate the biomechanical properties of the tissues in vivo for detecting the onset and progression of degenerative or other diseases (such as keratoconus).

An excitation force (internal or external) and phase-sensitive optical coherence elastography (OCE) system, used in conjunction with a data analyzing algorithm, is capable of measuring and quantifying biomechanical parameters of tissues in situ and in vivo. The method was approbated and demonstrated on an example of the system that combines a pulsed ultrasound system capable of producing an acoustic radiation force on the crystalline lens surface and a phase-sensitive optical coherence tomography (OCT) system for measuring the lens displacement caused by the acoustic radiation force. The method allows noninvasive and nondestructive quantification of tissue mechanical properties. The noninvasive measurement method also utilizes phase-stabilized swept source optical coherence elastography (PhS-SSOCE) to distinguish between tissue stiffness, such as that attributable to disease, and effects on measured stiffness that result from external factors, such as pressure applied to the tissue. Preferably, the method is used to detect tissue stiffness and to evaluate the presence of its stiffness even if it is affected by other factors such as intraocular pressure (TOP) in the case of cornea, sclera, or the lens. This noninvasive method can evaluate the biomechanical properties of the tissues in vivo for detecting the onset and progression of degenerative or other diseases (such as keratoconus).

An ophthalmic system for visualization of interactions between ocular matter and a probe tip of a probe within or in contact with an ocular space of an eye includes: a visualization tool having a field of view that includes at least a portion of the ocular space of the eye where the probe tip interfaces with the ocular matter; and a stroboscopic illumination source configured to stroboscopically illuminate at least the portion of the field of view at an illumination frequency. A method of operating a stroboscopic illumination source during an ophthalmic surgical procedure includes: identifying an illumination source type of the stroboscopic illumination source; identifying a probe type; identifying a first procedure trigger; and operating the stroboscopic illumination source based on the probe type, the illumination source type, and the first procedure trigger.

What is provided are methods of analyzing at least one image of the anterior segment of an eye and for selecting an intraocular lens (IOL). The methods may include detecting at least one image from an anterior segment of the eye; identifying a location of a reference structure on the eye using a plurality of points of a landmark on the anterior segment of the eye; and calculating at least one quantitative dimension of the anterior segment of the eye using the reference structure. The newly identified landmarks and quantifiable dimensions improve the characterization of the anterior segment in order to better predict the position and movement of the intraocular lens. The improved methods for analyzing the imaging of the anterior segment of the eye allows for improvements in the refractive outcomes of cataract surgery, glaucoma procedures, refractive outcomes, and other eye-related diseases.