The present disclosure relates to a new class of antimicrobial agents. In particular, this disclosure provides the identification and characterization of novel spiro-lactam compounds as anti-HIV/AIDS and anti-malarial agents. Furthermore, this disclosure also provides the preparation of spiro--penicillanic acids, which proved to be potent inhibitors of HIV.

A method may include generating a series of two-dimensional (2D) ultrasound images of the tissue volume associated with a plurality of positions along a scanning direction of the tissue volume; estimating, for each pair of consecutive 2D ultrasound images of the series of 2D ultrasound images, a distance between the positions associated with the pair of consecutive 2D ultrasound images based on a classification of a difference image generated from the pair of consecutive 2D ultrasound images using a deep neural network to produce a plurality of estimated distances associated with the plurality of pairs of consecutive 2D ultrasound images, respectively modifying the number of 2D ultrasound images in the series of 2D ultrasound images based on the plurality of estimated distances to produce a modified series of 2D ultrasound images and rendering the 3D ultrasound image of the tissue volume based on the modified series of 2D ultrasound images.

An ultrasound diagnosis apparatus comprises processing circuitry configured to set initial values for a set of imaging parameters for use in acquiring ultrasound data for an ultrasound image, the set of imaging parameters comprising at least one acquisition parameter; acquire the ultrasound data according to the initial values for the set of imaging parameters, and process the ultrasound data to obtain the ultrasound image; extract imaging information in a region of interest of the ultrasound image; obtain predicted values for the set of imaging parameters using the extracted at least one feature and a machine learning algorithm trained using user-selected values for the set of imaging parameters, wherein the user-selected values are selected to provide a preferred appearance of the region of interest; and set the predicted values for the set of imaging parameters for use in acquiring further ultrasound data for a further ultrasound image.

A portable ultrasonic imaging probe that is adapted to connect to a host computer via a passive interface cable. The probe includes an array of ultrasound transducers, a high voltage pulser for energizing transducers to emit an ultrasound pulse, analog signal processing circuitry that combines echoes detected by transducers into a single analog echo signal, am analog-to-digital converter that converts the analog echo signal into a digital echo signal; and interface circuitry that transfers the digital echo signal across the passive interface cable to the host computer. The probe includes transmit switches configured to selectively connect sets of ultrasound transducers to the HV pulser and a plurality of receive switches configured to selectively connect sets of ultrasound transducers to the analog signal processing circuitry.

An intravascular ultrasound probe is disclosed, incorporating features for utilizing an advanced transducer technology on a rotating transducer shaft. In particular, the probe accommodates the transmission of the multitude of signals across the boundary between the rotary and stationary components of the probe required to support an advanced transducer technology. These advanced transducer technologies offer the potential for increased bandwidth, improved beam profiles, better signal to noise ratio, reduced manufacturing costs, advanced tissue characterization algorithms, and other desirable features. Furthermore, the inclusion of electronic components on the spinning side of the probe can be highly advantageous in terms of preserving maximum signal to noise ratio and signal fidelity, along with other performance benefits.

A test tube rack of an analyzer pipeline includes multiple test tube holders for holding test tubes. The test tube rack of an analyzer pipeline comprises a light blocker configured at a side wall of the test tube rack and across multiple test tube holders. A second feature area is on the light blocker between two adjacent test tube holders, a first feature area is between two adjacent second feature areas and a step gap with a predetermined depth is between the first feature area and a second feature area.

A method and system for anatomical landmark detection in medical images using deep neural networks is disclosed. For each of a plurality of image patches centered at a respective one of a plurality of voxels in the medical image, a subset of voxels within the image patch is input to a trained deep neural network based on a predetermined sampling pattern. A location of a target landmark in the medical image is detected using the trained deep neural network based on the subset of voxels input to the trained deep neural network from each of the plurality of image patches.

An imaging system that utilizes deterministic bit sequences modulated onto an in-phase component of a carrier frequency and continuously transmitted via a transducer and received for imaging a medium and/or environment is provided. The received signal is demodulated by an in-phase demodulator and a quadrature demodulator and the demodulated components are processed to provide a spatial mapping of a medium or environment being imaged.

A medical device-placing system including a medical-device tip-location sensor (TLS) configured for placement on a chest of a patient, an ultrasound probe, a console, and an alternative-reality headset. The ultrasound probe can be configured to emit ultrasound signals into the patient and receive echoed ultrasound signals from the patient. The console can be configured to transform the echoed ultrasound signals to produce ultrasound-image segments corresponding to anatomical structures of the patient, as well as transform TLS signals from the TLS into location information for a medical device within the patient. The alternative-reality headset can include a display screen through which a wearer of the alternative-reality headset can see the patient. The display screen can be configured to display over the patient a virtual medical per the location information for the medical device within objects of virtual anatomy corresponding to the ultrasound-image segments.

The present invention related to an ultrasound imaging system win which the scan head includes a beamformer circuit that performs far field subarray beamforming or includes a sparse array selecting circuit that actuates selected elements. When using a hierarchical two-stage or three-stage beamforming system, three dimensional ultrasound images can be generated in real-time. The invention further relates to flexible printed circuit boards in the probe head. The invention furthermore related to the use of coded or spread spectrum signaling in ultrasound imagining systems. Matched filters based on pulse compression using Golay code pairs improve the signal-to-noise ratio thus enabling third harmonic imaging with suppressed sidelobes. The system is suitable for 3D full volume cardiac imaging.