A method for administering tests using a regional antigen testing kit is provided. The method comprises providing the regional antigen testing kit, extracting a predetermined amount of concentrated antigen from one of a plurality of concentrated antigens, dispensing the predetermined amount of concentrated antigen into a corresponding one of a plurality of wells, as indicated by visual indicia, repeating the extracting and dispensing steps until a desired number of the plurality of wells contain concentrated antigen, providing a prick tester having a plurality of needles extending thereon, aligning the plurality of needles of the prick tester with the plurality of wells, inserting each of the plurality of needles of the prick tester into one of the plurality of wells, and applying the plurality of needles of the prick tester to the skin of a patient to elicit a potential response.

A method for producing prick test single use sterile vials for use in a prick test is provided. The method comprises providing at least one allergen source including therewithin allergen extract, providing a plurality of single dose vials, connecting a tube to the at least one allergen source, connecting a metering device to the tube, drawing by the tube an amount of the allergen extract from one of the at least one allergen source, receiving the amount of allergen extract at the metering device, and dispensing by the metering device a volume of allergen extract into one of the plurality of single dose vials.

The present invention is directed to a method for inducing an immune response in a subject, including a step of activating neurons in the mesolimbic network of the subject by applying a neurofeedback.

Described herein are treatments and preventions for atopic dermatitis (AD), antibodies and pharmaceutical compositions for use in the treatment or prevention of AD, and uses of an anti-IL-31RA antibody (e.g., nemolizumab) in the manufacture of a medicament for the treatment or prevention of AD. Also described herein are biomarkers of AD and methods of altering or improving these biomarkers via treatments with an antibody that binds to IL-31RA (e.g., nemolizumab).

An automated allergy office system and method provides a medical professional with a new allergy treatment plan to administer to a patient. The automated allergy office system comprises a viewing device to select a test site on the patient's skin that is clear. A multiple test applicator is in cooperative engagement with a fluid tray and delivers a small amount of a first allergen to a first test site on the patient's skin as a small amount of a second allergen is delivered to a second test site on the patient's skin. The allergy condition of the patient is detected as a wheal forms at the first test site after fifteen minutes. The elements of the treatment plan are retrieved from a database for treating the patient's allergy condition. The patient's electronic medical record is checked to confirm that the allergy treatment is new for this patient.

The present invention relates to a device (10) for obtaining a sample (30) from a biological material (40) in solid form, said device comprising an array of micro-needles (30) arranged on a base plate (20). It further relates to a method for obtaining a sample (50) from a biological material (40) in solid form, comprising pressing the micro-needles (30) of the device (10) into said biological material (40), and subsequently removing the device from the biological material (40), and to the use of the device (10) in such a method.

The present disclosure relates to a minimally-invasive skin biopsy method. The minimally-invasive skin biopsy method according to the present disclosure includes: preparing a microneedle patch; attaching the microneedle patch to a skin of an object; maintaining a state in which the microneedle patch is attached to the skin of the object for a predetermined period of time; and detaching the microneedle patch from the skin of the object after the predetermined period of time, and analyzing a protein component of the object, which adheres to a microneedle of the microneedle patch. The microneedle is made of a biocompatible polymer substance.

Multi-layer contact patches, as well as related apparatus, kits, systems, and methods, enable improved allergen testing and diagnosis. Multi-layer contact patches include a shield layer releasably coupled to an adhesive layer. The adhesive layer at least partially defines and is fixably coupled to an allergen complex layer. The allergen complex layer defines a plurality of allergen complex cavities. At least a subset of the allergen complex cavities include an allergen complex positioned therein, each allergen complex comprising an absorbent matrix and an allergen.

The present invention provides a dermal patch for selectively retaining one or more analyte(s) from a body of a subject comprising: a membrane layer (101) for retaining one or more analyte(s) from a body of a subject, with a first and a second side, wherein the first side is adapted to be in fluid communication with the skin of the subject; optionally holding means for securing the membrane layer in place; an adhesive layer (104); and a backing layer; wherein between the backing layer and the membrane layer (101) there is an expandable layer (103) for applying pressure to the membrane layer.

A method for administering tests using a regional antigen testing kit is provided. The method comprises providing the regional antigen testing kit, extracting a predetermined amount of concentrated antigen from one of a plurality of concentrated antigens, dispensing the predetermined amount of concentrated antigen into a corresponding one of a plurality of wells, as indicated by visual indicia, repeating the extracting and dispensing steps until a desired number of the plurality of wells contain concentrated antigen, providing a prick tester having a plurality of needles extending thereon, aligning the plurality of needles of the prick tester with the plurality of wells, inserting each of the plurality of needles of the prick tester into one of the plurality of wells, and applying the plurality of needles of the prick tester to the skin of a patient to elicit a potential response.