A skin penetration device (2, 102, 202, 302) for administering a test substance (10). The skin penetration device has a first layer (4, 104, 204, 304), a second layer (6, 106, 206, 306), and a third layer (12, 212, 312). It may also have a fourth layer (16, 116, 216). The second layer has a protrusion (8, 108, 208, 308) providing a hollow space for containing the substance to be administered. In The skin penetration device further has a skin-piercing component (18, 118, 218, 318) that can release the substance and rupture the skin when pressed towards the skin in use. The skin-piercing component has a rest configuration and is configured to be biased towards the rest configuration such that it may be deformed but returns to the rest configuration when the deforming force is removed.

There are provided a micro-needle patch for diagnosing and treating an allergy disease which can easily and effectively inject an allergen into a dermal layer of an entity, a method for producing the micro-needle patch, and a method for diagnosing an allergy disease using the micro-needle patch.

The micro-needle patch includes a plurality of micro-needles constructed to inject an allergen into an entity; and a pad for supporting the plurality of micro-needles.

The micro-needle patch in accordance with the present disclosure may inject the allergen easily and effectively into the dermis of the entity, thereby to allow diagnosing or treating the allergy disease easily and efficiently without causing great pain to the patient. Further, controlling the type and content of the allergen contained in the micro-needle patch may allow diagnosing or treating allergy diseases accurately.

The invention relates to a device for use in skin improvement or repair, including promoting hair growth, comprising the use of microneedles for the transplantation of cells and a method employing the use of same.

An apparatus for skin prick testing of immediate allergic reactions by a plurality of applied allergens. The apparatus is provided in three configurations including, respectively, a single head element, an arrangement of two rows of head elements, and an arrangement of three rows of head elements. Use of the apparatus forms the basis for a method of allergy testing, while the apparatus may be provided as a kit for allergy testing, the kit forming an assembly once combined. The kit includes the apparatus in a two or three row configuration, a lower tray with allergen cavities suitable for accepting the head elements of each apparatus, a top tray insert for stable and piloted positioning of each apparatus above the lower tray, and a removeable cover affixable to the lower tray thereby securing the top tray with one or more of the apparatus in an enclosed assembly formed by the kit.

Apparatus for injection into the skin by superficial incision comprising a main body, et tips for incision of the skin protruding from the body, the apparatus being able to have a configuration in which the tips define an entirely curved surface, the surface being convex in a longitudinal direction, and a center of curvature of a section of the surface in a longitudinal plane parallel to the longitudinal direction and the body are on the same side of the surface.

Embodiment provided herein are directed to microneedle patches for agent application on a mammal skin. The microneedle patch may comprise a patch scaffold having a surface, and a plurality of microneedles disposed on the surface. Each of the microneedles may be capable of piercing the skin 50 m to 1000 m deep, and comprises a composite material comprising polyvinylpyrrolidone (PVP) and one or more additional copolymers selected from the group consisting of maltose, leucine, and dileucine.

A device (10) for performing an allergy test comprising a container unit (11) having a first surface (12) and a second surface (13). The container unit (11) comprising a plurality of cavities (22) each arranged for receiving an allergen container (14) comprising a supporting material (18) and a pricking tool, which is secured at a location of the supporting material (18). The supporting material (18) is arranged, when a pressure force is applied on the second surface (13), for being compressed thereby causing the pricking tool (19) for being displaced from a first position (25), wherein at said first position the at least one pricking tip (24) is at a first distance from the first surface (12), to a second position (26), wherein at said second position (26) the at least one pricking tip (24) is at a second distance from the first surface (12).

A test chamber for epicutaneous patch test units is provided. The test chamber is formed of a multilayer material including at least one absorbent layer and at least one barrier layer. The test chamber is adapted to contain a liquid or petrolatum-based allergen. The absorbent layer absorbs the liquid or petrolatum-based allergen, while the barrier layer prevents the allergen from migrating out of the test chamber.

An allergy skin testing device includes a central post having a sharp portion, a longitudinal portion, and a guide portion. The sharp portion has one or more sharp probes extending longitudinally. The guide portion facilitates guiding the sharp portion towards the skin. The device also includes a compressible annular pain-reduction structure having an annular dull probe portion, a resilient compressible portion, and an optional base portion. The annular dull probe portion initially extends beyond the sharp portion, and has a passageway allowing passage of the sharp portion therethrough, the annular dull probe portion being configured to activate a surrounding pain gate effect (a pain gate fence) when pressed against the skin. The resilient compressible portion is configured to compress along the longitudinal portion of the central post. The base portion is configured to be pushed by the guide portion when the annular dull probe portion is pressed against the skin.

Single and multiple allergy skin testing devices with rigid annular pain-reduction structures supported by respective compressible sleeves. Each rigid annular pain-reduction structure presses against skin before and while at least one corresponding sharp probe presses against the skin surrounded by the rigid annular pain-reduction structure, thereby causing a surrounding pain gate effect to reduce perceived pain due to the at least one sharp probe. Each allergy skin testing device includes: a central post having a sharp portion, a longitudinal portion, and a guide portion; a compressible structure having a leading portion, a resilient compressible portion, and a base portion; and a rigid annular probe portion having an annular skin-contacting surface. The surrounding pain gate effect is activated when the annular skin-contacting surface is pressed against the skin before and while the one or more sharp probes are pressed against the skin surrounded by the annular skin-contacting surface to administer allergen.