The invention relates to a device for use in skin improvement or repair, including promoting hair growth, comprising the use of microneedles for the transplantation of cells and a method employing the use of same.

An allergy skin test device can include a support strip having a top and bottom face. An allergen can be applied to an area of the bottom face forming an allergen portion. A skin viewing portion can be located proximate or at the allergen portion. An adhesive can be applied to an area of the bottom face forming an adhesion portion. When applied to the skin of a subject, the allergy skin test device can facilitate viewing of a portion of the skin beneath the allergy skin test device through the skin viewing portion. A method of testing a subject for an allergy can include applying an allergy skin test device to the skin of the subject, recording two or more images of the skin of the subject, and electronically comparing the images.

Methods and items useful at least therein are provided for IBS related testing and treatment. Disclosed is a patch useful in determining if one or more test materials can cause allergic contact dermatitis in a patient. A kit containing information on use and that may include such a patch and/or test material(s) is also disclosed. A method of IBS related testing including performing skin patch testing on a patient presenting IBS symptoms using at least one test material that can cause allergic contact dermatitis is provided. A method for the treatment of IBS which includes limiting the intake by a patient presenting IBS symptoms of at least one material that gives a positive skin patch test result in the patient is also disclosed.

The present invention related to a matrix, a patch and a method for non-invasive sampling of at least one endogenous substance on a skin surface of an individual, wherein the matrix comprises at least one amphiphile, wherein the amphiphile, alone or in combination with at least one structurally related amphiphile, forms a non-lamellar liquid crystalline phase together with an aqueous polar solvent mixture, said matrix comprising a water activity of at least 0.85 in a temperature range of 20-40 C., wherein the matrix is configured to extract said at least one endogenous substance on the skin surface of the individual.

Multi-layer contact patches, as well as related apparatus, kits, systems, and methods, enable improved allergen testing and diagnosis. Multi-layer contact patches include a shield layer releasably coupled to an adhesive layer. The adhesive layer at least partially defines and is fixably coupled to an allergen complex layer. The allergen complex layer defines a plurality of allergen complex cavities. At least a subset of the allergen complex cavities include an allergen complex positioned therein, each allergen complex comprising an absorbent matrix and an allergen.