A MEM-based device and method of fabrication, the device comprising a biochip substrate comprising one or more compliant materials, a plurality of mechanical and electrical micro-sensors configured in an array to simultaneously measure electrical and mechanical properties of a sample, wherein a first mechanical micro-sensor is formed as a patterned layer of at least one of the compliant materials, wherein the patterned layer is coupled to a first pillar comprising a dielectric material formed onto the compliant materials, the first pillar being coated with a metal film at a contact surface with the sample and along a side of the first pillar to act as a conductive probe for the first electrical micro-sensor, and wherein the first pillar is formed on the first mechanical micro-sensor to transfer a force to the first mechanical micro-sensor.

A method for obtaining a probability in a 3D probability map, includes: obtaining at least one value of at least one parameter for each stop of a 3D moving window, wherein a first, second, third and fourth of the stops are partially overlapped, the first and second stops are shifted from each other by a distance equal to a first dimension of a computation voxel, the first and third stops are shifted from each other by a distance equal to a second dimension of the computation voxel, and the first and fourth stops are shifted from each other by a distance equal to a third dimension of the computation voxel; matching the at least one value to a classifier to obtain a first probability for each stop of the 3D moving window; and calculating a second probability for the computation voxel based on information associated with the first probabilities for the first through fourth stops.

Methods, devices, apparatuses and systems are disclosed for performing mammography, such as utilizing tomosynthesis in combination with breast biopsy.

A specimen holding and positioning apparatus operable to substantially non-movably maintain a specimen (e.g., an excised tissue specimen) in a fixed or stable orientation with respect to the apparatus during imaging operations (e.g., x-ray imaging), transport (e.g., from a surgery room to a pathologist's laboratory), and the like for use in facilitating accurate detection and diagnosis of cancers and/or other abnormalities of the specimen.

The present invention provides an in vitro method for selecting a patient affected with a tumor for an immunotherapy treatment or for predicting the response of a subject affected with a tumor to an immunotherapy treatment, wherein the method comprises: (a) detecting DPP4.sup.+ CAFs (Cancer Associated Fibroblast), and/or CD73.sup.+ CAFs, and/or B7H3.sup.+ CAFs, and/or OX40L.sup.+ CAFs, and/or JAM2.sup.+ CAFs in a cancer sample from said patient; (b) determining the level(s) of DPP4.sup.+ CAFs, and/or CD73.sup.+ CAFs, and/or B7H3.sup.+ CAFs, and/or OX40L.sup.+ CAFs, and/or JAM2.sup.+ CAFs in said cancer sample, wherein the responsiveness of said patient to an immunotherapy treatment is inversely proportional to the level(s) of DPP4.sup.+ CAFs, and/or CD73.sup.+ CAFs, and/or B7H3.sup.+ CAFs, and/or OX40L.sup.+ CAFs, and/or JAM2.sup.+ CAFs in the cancer sample; (c) optionally, selecting patients with low level(s) of DPP4.sup.+ CAFs, and/or CD73.sup.+ CAFs, and/or B7H3.sup.+ CAFs, and/or OX40L.sup.+ CAFs, and/or JAM2.sup.+ CAFs as suitable for an immunotherapy treatment.

A device and methods for performing a simulated CT biopsy on a region of interest on a patient. The device comprises a gantry (22) configured to mount an x-ray emitter (24) and CT detector (26) on opposing sides of the gantry, a motor (28) rotatably coupled to the gantry such that the gantry rotates horizontally about the region of interest, and a rotation of source high resolution x-ray detector (172) positioned adjacent the CT detector in between the CT detector and and detector the x-ray emitter.

A breast cavity spacer device, a kit for performing a biopsy and a method of performing a biopsy, such as for use with a percutaneous lumpectomy, is provided. The breast cavity spacer device includes a catheter. A self-sealing balloon member is removably and fluidly coupled on one end of the catheter. An umbrella valve is coupled to the catheter adjacent the balloon member, the umbrella valve being configured to fluid flow into the balloon in response to fluid flow from an end of the catheter opposite the balloon and prevent fluid flow from the balloon when fluid flow from the end of the catheter is stopped.

Methods and systems for assessing the risk of a human female subject for developing breast cancer. In particular, the present disclosure relates to combining a first clinical risk assessment, a second clinical assessment based at least on breast density, and a genetic risk assessment, to obtain an improved risk analysis.

A biopsy device includes an elongated handle body having a proximal end portion and a distal end portion, a needle disposed within the handle body, first and second transducers, and a display. The needle is configured to move between a retracted position and a deployed position. The first and second ultrasound transducers are disposed within the distal end portion of the handle body. The first and second ultrasound transducers are angled relative to one another and define a space therebetween configured for passage of the needle.

Embodiments related to medical imaging devices including rigid imaging tips and their methods of use for identifying abnormal tissue within a surgical bed are disclosed.