An endoscope biopsy device has a hub, an insertion tube connected to the hub, an endoscope module connected to the hub, and a biopsy module connected to the hub. The endoscope module includes a fiber optic line extending through the hub and into the insertion tube. The biopsy module is configured to admit biopsy tools to the patient through the insertion tube from the biopsy module while simultaneously providing a visual examination of the portion of the patient from which the biopsy is taken. In some embodiments, the endoscope biopsy device is configured to perform a biopsy during a ductoscopy on a human patient.

A method for treatment of a disease by monitoring a progression of the disease includes obtaining image data including a representation of diseased cells of a patient. Based on the type of the disease, one or more features to extract from the image data are determined, the features each representing a physical parameter of at least one of the diseased cells represented in the image data. A feature vector is formed from the extracted features. A machine learning model is selected, and the feature vector is processed using the machine learning model. The machine learning model is trained with labeled image data representing instances of diseased cells having the disease and associating scores representing predicted rates of disease progression with the respective instances of diseased cells having the type of disease. Based on the processing, a score is determined that represents a predicted rate of disease progression indicated by the image data.

A device and methods for performing a simulated CT biopsy on a region of interest on a patient. The device comprises a gantry (22) configured to mount an x-ray emitter (24) and CT detector (26) on opposing sides of the gantry, a motor (28) rotatably coupled to the gantry such that the gantry rotates horizontally about the region of interest, and a rotation of source high resolution x-ray detector (172) positioned adjacent the CT detector in between the CT detector and the x-ray emitter.

A method of analysis using mass spectrometry and/or ion mobility spectrometry is disclosed comprising: (a) using a first device to generate smoke, aerosol or vapour from a target in vitro or ex vivo cell population; (b) mass analysing and/or ion mobility analysing said smoke, aerosol or vapour, or ions derived therefrom, in order to obtain spectrometric data; and (c) analysing said spectrometric data in order to identify and/or characterise said target cell population or one or more cells and/or compounds present in said target cell population.

A method of analysis using mass spectrometry and/or ion mobility spectrometry is disclosed. The method comprises: using a first device to generate smoke, aerosol or vapour from a target comprising or consisting of a microbial population; mass analysing and/or ion mobility analysing said smoke, aerosol or vapour, or ions derived therefrom, in order to obtain spectrometric data; and analysing said spectrometric data in order to analyse said microbial population.

A method of analysis using mass and/or ion mobility spectrometry or ion mobility spectrometry is disclosed comprising: using a first device to generate aerosol, smoke or vapour from one or more regions of a first target of biological material; and mass and/or ion mobility analysing and/or ion mobility analysing said aerosol, smoke, or vapour, or ions derived therefrom so as to obtain first spectrometric data. The method may use an ambient ionisation method.

Surgical cutting apparatus (1) for removal of human tissue tumour. The apparatus (1) comprises a first knife (2) with a circular shaped side wall (5) comprising a cutting edge (6). The first knife (2) being arranged for cutting tissue in a first direction (7). The apparatus (1) comprises a shank (8), wherein the shank (8) has a width (w) of less than 15 millimetres. The first knife (2) has a height (h) of less than 15 millimetres. The shank (8) being a yoke comprising two legs (8a, 8b) interconnected at their respective second shank ends (10a, 10b). The apparatus (1) permitting removal of human tissue tumour by firstly bringing the first knife (2) under the skin through a narrow incision, and secondly cutting the tissue in the first direction (7) axially with the first knife (2), by an axially pressing and rotating movement of the first knife (2).

The present disclosure includes customized guidance devices in the form of guidance templates configured to fit over a given area of a patient's body and provide guidance during a tissue treatment or tissue removal procedure of that given area, which may include administration of an agent to a target tissue, target tissue biopsy, target tissue resection, or target tissue ablation. The customized guidance templates are generally constructed via an additive manufacturing process (i.e., three-dimensional (3D) printing) or subtractive manufacturing process (i.e., milling) based on a fabrication instruction file, which may include imaging data of the given area of the patient's body in which targeted tissue treatment is to be performed. The fabrication instruction file may further include additional data, such as the type of procedure to be performed (i.e., biopsy of the tissue abnormality, destruction or resection of the tissue abnormality, etc.).

A method of analysis using mass spectrometry and/or ion mobility spectrometry is disclosed. The method comprises: using a first device to generate smoke, aerosol or vapour from a target comprising or consisting of a microbial population; mass analysing and/or ion mobility analysing said smoke, aerosol or vapour, or ions derived therefrom, in order to obtain spectrometric data; and analysing said spectrometric data in order to analyse said microbial population.

A method of mass spectrometry or ion mobility spectrometry is disclosed comprising: providing an analyte; supplying a matrix compound to said analyte such that said analyte dissolves in said matrix; forming first droplets of the dissolved analyte; and colliding said first droplets with a collision surface. The use of matrix improves the analyte ion signal.