A depth stop assembly for use with a biopsy device targeting cannula includes a depth stop and a thumbwheel. The depth stop is configured to receive the targeting cannula. The depth stop has a lock to selectively restrict axial movement of the targeting cannula relative to the depth stop. The thumbwheel is motion-coupled to the depth stop. The thumbwheel has a circumferential finger gripping area.

An apparatus is disclosed including a tool comprising a first device for generating aerosol from a target, the first device being deployed through an opening in a tubing of the tool, wherein the tubing is provided with aspiration ports or fenestrations such that the generated aerosol is aspirated into the tubing via the aspiration ports or fenestrations. The aspirated aerosol is then transferred to a mass spectrometer for subsequent mass analysis.

A method is disclosed comprising obtaining or acquiring chemical or other non-mass spectrometric data from one or more regions of a target (2) using a chemical sensor (20). The chemical or other non-mass spectrometric data may be used to determine one or more regions of interest of the target (2). An ambient ionisation ion source 1 may then be used to generate aerosol, smoke or vapour (5) from one or more regions of the target (2).

A marker delivery device including a handle assembly, a delivery catheter, and a connection interface. The handle assembly has an upper push rod positioned within the handle assembly. The upper push rod is adapted to translate inside the handle assembly. The delivery catheter is adapted to be inserted into a biopsy site. Also, the delivery catheter has a discharge opening containing a marker and the delivery catheter has a lower push rod positioned inside of the delivery catheter. The lower push rod is configured to engage the upper push rod and the lower push rod is adapted to deploy the marker from the delivery catheter into the biopsy site through the discharge opening with the translation of the upper push rod. The connection interface is configured to removably attach the handle assembly with the delivery catheter and the upper push rod with the lower push rod.

A method and means to utilize machine learning to train a device to generate a confidence level indicator (CLI). The device is a CAD system that has been initially trained using initial machine learning to recommend classifications for image features presented to the device. Probabilistic classification is utilized to incorporate intermediate values given by a human operator to better indicate a level of confidence of the CAD system's recommendations as to what classes should be associated with certain image features.

A bi-directional depth stop for use with biopsy instrument including a body and a pair of blades. The body defines a channel sized to receive a cannula associated with the biopsy instrument. The channel includes a first pair of opposing concave surfaces and a second pair of opposing concave surfaces. The first pair and second pair of opposing concave surfaces together form a superimposed bi-oval-shaped cross-section. Each blade of the pair of blades projects inwardly into a concave surface of the first pair of opposing concave surfaces such the pair of blades are disposed on an opposing side of the body. In some instances, the concave surfaces may be beneficial to provide rotation of the dept stop in two directions rather than a single direction.

An apparatus for performing ambient ionisation mass and/or ion mobility spectrometry is disclosed. The apparatus comprises a substantially cylindrical, tubular, rod-shaped, coil-shaped, helical or spiral-shaped collision assembly; and a first device arranged and adapted to direct analyte, smoke, fumes, liquid, gas, surgical smoke, aerosol or vapour onto said collision assembly.

Methods and systems for identifying and quantifying molecular biomarkers and for predicting patient response to cancer therapy are provided. The disclosed methods and systems make use of artificial intelligence to capture morphometric changes from histopathology tissue that correlate with molecular changes. The system may analyze molecular markers which are predictive of tumor response and have no defined correlation with morphological features. The system may use artificial intelligence to correlate morphometric changes with critical gene modifications and molecular changes.

A multimodal system for breast imaging includes an x-ray source, and an x-ray detector configured to detect x-rays from the x-ray source after passing through a breast. The system includes an x-ray detector translation system operatively connected to the x-ray detector so as to be able to translate the x-ray detector from a first displacement from the breast to a second displacement at least one of immediately adjacent to or in contact with the breast. The system includes an x-ray image processor configured to: receive a CT data set from the x-ray detector, the CT data set being detected by the x-ray detector at the first displacement; compute a CT image of the breast; receive a mammography data set from the x-ray detector, the mammography data set being detected by the x-ray detector at the second displacement; and compute a mammography image of the breast.

A method for detecting cancer involved lymph nodes. The method includes placing a pH-sensing paper inside a needle of an injection syringe, filling the injection syringe with a buffer solution, putting the pH-sensing paper in contact with lymphatic fluid of a lymph node by inserting the needle of the injection syringe inside the lymph node, putting the lymphatic fluid in interaction with the buffer solution by injecting the buffer solution into the lymph node utilizing the injection syringe, and detecting that the lymph node as a cancer involved lymph node if color of the pH-sensing paper is changed to an acidic-range pH color.