The present disclosure relates to a device for detection of gaseous amines, originating from disease in the human urogenital system. The device comprising an inner surface 1 for facing the user and outer surface 3 for facing away from the user, wherein said device comprises a removable indicator 5 of gaseous amines. The removable indicator 5 is configured to be arranged in an indicator pocket 6. The device is made of a flexible material of a shape adapted to cover orifices of the human urogenital system but not the anus.

A new system monitors ethanol alcohol levels of a vehicle operator by collecting sweat from the operator's hands, and detecting the presence, if any, of ethanol in the sweat. The system can then be used, if ethanol is present, to take action, such as immobile vehicle disablement, in the event of intoxication caused by an impermissibly high levels of ethanol of the operator. The system includes devices, referred to as pods in the description, which are sweat-collecting devices that are attached to the steering wheel of the vehicle. If the measurable ethanol in collected moisture from the operator's hands exceeds a preset threshold, the system could be configured to warn the operator to park the vehicle thereafter to disable operation of the vehicle, but if the operator does not so discontinue operation of the vehicle hazard warning lights and audible warnings within and without the vehicle will be activated alerting near vehicles of a dangerous vehicle being operated in close proximity. Likewise the new system monitors for pulse rate and oxygen levels of the operator can be used to recommend operator action when the pulse rate and/or oxygen levels are outside of the normal range for an operator. When the pulse rate and or oxygen levels of the system are outside of the normal parameters for an operator, the system will warn the operator to park the vehicle and thereafter to disable operation of the immobile vehicle, but if the operator does not so discontinue operation of the vehicle the hazard warning lights, on board video, and audible warnings within and without the vehicle will be activated alerting near vehicles of a dangerous vehicle being operated in close proximity, and alarms will be sent to real time recording and monitoring devices.

A method of analysis using mass spectrometry and/or ion mobility spectrometry is disclosed comprising: (a) using a first device to generate smoke, aerosol or vapour from a target in vitro or ex vivo cell population; (b) mass analysing and/or ion mobility analysing said smoke, aerosol or vapour, or ions derived therefrom, in order to obtain spectrometric data; and (c) analysing said spectrometric data in order to identify and/or characterise said target cell population or one or more cells and/or compounds present in said target cell population.

Embodiments herein include gas sampling catheters, systems and related methods. In an embodiment, a gas sampling catheter is included. The catheter can include a catheter shaft having a proximal end and a distal end, the catheter shaft defining a lumen therein. The catheter can include a gas sampling port providing fluid communication between the exterior of the catheter shaft adjacent the distal end of the lumen of the catheter shaft. The catheter can further include a sensor element disposed in fluid communication with the lumen, the sensor element configured to detect a component of a gaseous sample. The sensor element can include a first measurement zone comprising a plurality of discrete binding detectors. Other embodiments are also included herein.

A method of ion imaging is disclosed that includes automatically sampling a plurality of different locations on a sample using a front device which is arranged and adapted to generate aerosol, smoke or vapour from the sample. Mass spectral data and/or ion mobility data corresponding to each location is obtained and the obtained mass spectral data and/or ion mobility data is used to construct, train or improved a sample classification model.

A method is disclosed comprising providing a biological sample on a swab, directing a spray of charged droplets onto a surface of the swab in order to generate a plurality of analyte ions, and analysing the analyte ions.

There is provided a kit of parts for assembly into an impactor (100) for aerosol component collection, such as for exhaled breath. The kit of parts is configured such that an impactor component (128) is receivable into the assembly such that, when a sealing component (136) is in a sample collection configuration and an aerosol sample is being received at an aerosol inlet (110) of a housing of the kit, in use, an aerosol flow path (124) of the aerosol sample is directed onto an impaction surface (130) of the impactor component (128) to promote aerosol deposition thereon. The kit of parts is further configured such that the sealing component (136) is changeable in the assembly into a sample containment configuration before removal of the impactor component (128) from the assembly, so as to retain any aerosol components deposited on the impaction surface (130).

A method of analysis using mass and/or ion mobility spectrometry or ion mobility spectrometry is disclosed comprising: using a first device to generate aerosol, smoke or vapour from one or more regions of a first target of biological material; and el mass and/or ion mobility analysing and/or ion mobility analysing said aerosol, smoke, or vapour, or ions derived therefrom so as to obtain first spectrometric data. The method may use an ambient ionisation method.

An apparatus for performing ambient ionization mass and/or ion mobility spectrometry is disclosed. The apparatus comprises a substantially cylindrical, tubular, rod-shaped, coil-shaped, helical or spiral-shaped collision assembly; and a first device arranged and adapted to direct analyte, smoke, fumes, liquid, gas, surgical smoke, aerosol or vapor onto said collision assembly.

An apparatus is disclosed comprising a first device for generating aerosol, smoke or vapour from one or more regions of a target, an inlet conduit to an ion analyser or mass spectrometer, the inlet conduit having an inlet through which the aerosol, smoke or vapour passes, and a Venturi pump arrangement arranged and adapted to direct the aerosol, smoke or vapour towards the inlet.