Provided is a biopsy instrument having an outer needle-locking member, which is capable of checking whether an inner needle is placed in target tissue and shooting an outer needle after the tissue is sufficiently introduced into the inner needle, thereby accurately collecting the target tissue that is to be.

The present disclosure provides a fluidic device including a first inlet, an outlet, and a channel positioned between the first inlet and the outlet. The channel is in fluid communication with the first inlet and the outlet. The fluidic device further includes a second inlet positioned between the first inlet and the outlet. The second inlet is in fluid communication with the channel. The fluidic device further includes a pump in fluid communication with the second inlet. The pump is configured to provide a first volume of pulsatile flow to the channel The first volume of pulsatile flow is greater than about 50 μL per pulse.

Devices and methods used to obtain core tissue samples are disclosed. The devices may be configured to drill into cortical bone and saw a hole into a bone lesion and/or bone marrow while obtaining the core tissue sample. The devices can include a motor and a clutch configured to rotate a trocar having a tip configured for drilling and an outer coax cannula having a trephine tip configured for sawing. The core tissue sample may be received within an inner cannula as an intermediate cannula cuts a hole in the bone lesion and/or bone marrow. The devices can include a spacer.

An impact biopsy device is disclosed. The impact biopsy device may be configured to displace various cutting elements, such as an outer tubular member and cutting element and a cannula to sever a tissue sample from a patient. The impact biopsy device may comprise an actuation system configured to transfer displacement or force to the cutting elements by the impact of an element on another element.

A needle system (10) comprises a needle arrangement and an actuator device (30). The needle arrangement comprises needle (21) and a rod (24). The needle has a proximal end (211) and a distal end (212) and a needle opening (203) at the distal end of the needle. The rod has a proximal end (221) and a distal end (222) and a length that is greater than the length of the needle. The rod comprises an elongated rod shaft portion (26) configured to fit inside the needle and a rod tip portion (23) located at the distal end of the rod. The actuator device comprises an actuator body (39) comprising a cavity (33) and a first opening (61) configured to interface with a fluid transportation device (70) to allow fluid into and/or out of the cavity and thereby allowing fluid to be injected and/or aspirated through the needle. The needle system has a closed state and an open state. The rod tip portion seals, or blocks, the needle opening in the closed state, and the rod tip portion is shifted forward relative to the needle and unseals, or unblocks, the needle opening in the open state. The proximal end of the needle is connected to the actuator body and the proximal end of the needle is open to the cavity. The rod is configured to interact with the actuator device such that at a change of volume of the cavity, a force is exerted on the rod in a distal direction, setting the needle arrangement in the open state.

A biopsy apparatus includes a piercing module having a probe drive slider coupled to a probe carrier body of a biopsy probe assembly, and has a primed position and a fired position. A nut housing has a home position and an extended position. A drive spindle is drivably coupled to a motor driveshaft, and is coupled to the nut housing. A firing spring is interposed between a motor housing and the probe drive slider. A release arm is pivotably coupled to a piercing module frame. When the probe drive slider is in the primed position and the release arm is in a latch position, the release arm is positioned to engage the probe drive slider to hold the probe drive slider in the primed position. A release slider releases the release arm from the latch position when the nut housing is moved from the home position to the extended position.

Limited physical access to target organs of patients inside an MRI scanner is a major obstruction to real-time MRI-guided interventions. Traditional teleoperation technologies are incompatible with the MRI environment and although several solutions have been explored, a versatile system that provides high-fidelity haptic feedback and access deep inside the bore remains a challenge. A passive and nearly frictionless MRI-compatible hydraulic teleoperator is provided designed for in-bore biopsies. A needle driver translates a needle in insertion and retraction directions via a clutch mechanism. A needle holder grips the needle via a retraction lock when the clutch mechanism of the needle driver releases the needle to hold a position of the needle during reposition of the needle driver.

Provided are embodiments of systems, devices and methods to aid in or perform the capsulotomy procedure via access into an eye through a small incision. Embodiments of the present disclosure may employ the unique characteristics of shape-memory materials to enable device access into the eye through the requisite small incision size, and via simple mechanical means either to create a template for surgeons to follow in order to create an appropriately-sized capsulotomy, or to create such a capsulotomy via cutting, tearing, or abrading the lens capsule.

The subject matter described herein provides non-invasive patch stripping methods for the collection of a skin sample. The patch stripping method includes applying and removing at least one adhesive patch, provided that a skin sample is adhered to the adhesive patch after removal. The at least one adhesive patch is supplied in an adhesive skin sample collection kit. Optionally, the adhesive skin sample collection kit further comprises a sample collector and/or instructions for use.

The subject matter described herein provides non-invasive patch stripping methods for the collection of a skin sample. The patch stripping method includes applying and removing at least one adhesive patch, provided that a skin sample is adhered to the adhesive patch after removal. The at least one adhesive patch is supplied in an adhesive skin sample collection kit. Optionally, the adhesive skin sample collection kit further comprises a sample collector and/or instructions for use.