A biopsy forceps device includes a tension member and an end effector including first and second jaws movable between an open configuration, in which the jaws are separated from one another to receive target tissue therebetween, and a closed configuration, in which cutting edges of the jaws are moved toward one another to cut a portion of the target tissue. The jaws define a tissue receiving space therebetween to house the cut tissue. The jaws are pivotable relative to one another, each of the jaws including a serrated cutting edge extending therealong, the end effector further including a tension member attachment including a proximal end coupled to the tension member. The attachment is movably coupled to the jaws so that distal movement of the attachment moves the jaws to the open configuration while proximal movement thereof moves the jaws to the closed configuration.

Prostate biopsy systems are provided that include a 3D ultrasound probe support configured to receive an ultrasound probe for transperineal imaging. One or more template grids can have a plurality of apertures extending therethrough to receive and guide a biopsy needle along a trajectory associated with respective apertures when the template grid is fixed to the support and the biopsy system is positioned in the perineal area of a patient. Patient-specific template grids can also be developed and produced. This system enables fully transperineal prostate biopsy (i.e. both imaging and needle placement are perineal) and eliminates the need for an external racking device for image fusion as well as needle tracking. In addition, it reduces the infection risk associated to transrectal approach.

The invention involves a device and method for acquiring bone marrow aspirate. The system includes an elongated cannulated fastener having a threaded end for attachment to a bone. The threaded portion includes a directional aperture sized to allow marrow to be drawn into the cannula. The directional aperture also allows the user to direct the aperture in a desired direction within the bone for acquisition of the marrow. The distal end of the cannulated fastener includes a connector which may be in the form of a Luer lock to allow vacuum to be applied to the cannula for drawing the marrow into a syringe or the like.

Even when an insertion object is inserted to a deep position of a subject or even when the insertion object is inserted into the subject at an angle close to a right angle, it is possible to confirm the position of the insertion object in a photoacoustic image. The insertion object is, for example, a hollow puncture needle 15 that includes an opening at a tip thereof. The puncture needle 15 includes a light guide member 152 that guides light emitted from a first light source to the vicinity of the opening, and a light emitting portion 153 that is provided in the vicinity of the opening and emits the light. First photoacoustic waves, which are caused by the light emitted from the light emitting portion 153, are generated in the puncture needle 15. A first photoacoustic image is generated on the basis of the first photoacoustic waves.

Even when an insertion object is inserted to a deep position of a subject or even when the insertion object is inserted into the subject at an angle close to a right angle, it is possible to confirm the position of the insertion object in a photoacoustic image. The insertion object is, for example, a hollow puncture needle 15 that includes an opening at a tip thereof. The puncture needle 15 includes a light guide member 152 that guides light emitted from a first light source to the vicinity of the opening, and a light emitting portion 153 that is provided in the vicinity of the opening and emits the light. First photoacoustic waves, which are caused by the light emitted from the light emitting portion 153, are generated in the puncture needle 15. A first photoacoustic image is generated on the basis of the first photoacoustic waves.

A biopsy system includes a biopsy device, a control module, and a tissue transport tube. The biopsy device includes a probe, a needle, a cutter, and a transport valve. The needle extends distally from the probe. The cutter is movable relative to the needle and defines a cutter lumen. The holster is configured to couple to the probe. The transport valve is in communication with the cutter lumen. The control module is in communication with the biopsy device and includes a sample management assembly configured to receive one or more tissue samples severed by the cutter. The transport tube extends between the sample management assembly and the biopsy device. The transport tube is in communication with the transport valve such that the transport tube is configured to receive the one or more tissue samples severed by the cutter.

A biopsy needle arrangement comprises a needle sheath and a needle. The biopsy needle arrangement is configured to be operatively connected to an actuator device configured to push the needle and the sheath distally in a sliding direction x. The biopsy needle arrangement further comprises a needle connector configured to attach the needle to the actuator device and a sheath connector configured to attach the needle sheath to the actuator device. The needle connector is configured to disengage the needle from the actuator device when the needle is subjected to a force in the sliding direction, which exceeds a threshold force. Also or alternatively, the sheath connector is configured to disengage the needle sheath from the actuator device when the needle sheath is subjected to a force in a direction opposite the sliding direction, which exceeds a threshold force.

The invention relates to a surgical instrument for separating and removing a biopsy. A suction channel for suctioning the biopsy out of a distal region in the direction of a proximal region is formed in a shaft, and/or a cutting tool is formed in one distal region or the distal region of the shaft, said cutting tool having a stationary cutting part and a counter cutting part which can be adjusted relative to the stationary cutting part about a rotational axis formed by a rotary joint wherein the cross-section of the suction channel expands in the suction direction from the distal region to the proximal region and/or the rotary joint is formed by two securing elements, each securing element being introduced from the interior to the exterior.

Methods and devices obtain cellular-component, e.g., proteins, RNA, DNA, metabolites, and combinations of these, from a solid tissue in-vivo using electroporation, and subsequently profile such tissue either inside or outside the subject's body. A method for determining if a solid tissue of a subject includes a benign or malignant tumor, or if a space occupying lesion (SOL) within the solid tissue is malignant or benign, includes placing at least one electroporation-electrode within the solid tissue, or within the SOL or in proximity thereto; applying pulsed electric field (PEF) via the at least one electroporation-electrode to thereby induce permeabilization of cells of the solid tissue or the SOL, and consequently release of at least one cellular-component therefrom to an extracellular matrix between and surrounding the cells; extracting the at least one cellular-component from the extracellular matrix.

A biopsy device includes a cylindrical hollow stylet having a proximal end, a distal end, and a uniform wall thickness. The proximal end and the distal end are disposed on the longitudinal axis. A longitudinal recess forms a sample chamber and is positioned adjacent the distal end of the cylindrical hollow stylet. A longitudinal insert has a longitudinal length, a distal terminal end, and an elongate channel. The longitudinal insert is positioned within the cylindrical hollow stylet with the distal terminal end proximal to the longitudinal recess. The longitudinal insert is immovably connected to the cylindrical hollow stylet. The elongate channel is configured to maintain a fluid passageway through the cylindrical hollow stylet from the proximal end to the longitudinal recess.