Apparatus, systems, and methods for endoscopic dissection of blood vessels and control over cavity pressure within an endoscopic procedure are described herein. Apparatus, systems, and methods for harvesting of blood vessels are also described herein.

Unitary endoscopic vessel harvesting devices with an elastic force are disclosed. In some embodiments, such devices comprise an elongated body having a proximal end and a distal end, a tip disposed at the distal end of the elongated body. The tip having a visual cue indicating a location of at least one cutting element extending from the elongated body.

The present invention provides systems, methods and devices for delivering media. The device can include a body designed to accommodate at least one cannister of a media, an body coupled to the body and having a distal end, and a tapered tip disposed at the distal end of the body and in fluid communication with the cannister, the tip being designed for advancing the distal end to a site of interest and through which media from the cannister can be directed to the site of interest. The device can also include a dispersion mechanism coupled to the body for controlled release of the media out the tapered tip.

Devices and methods for the treatment of chronic total occlusions are provided. One disclosed embodiment comprises a method of facilitating treatment via a vascular wall defining a vascular lumen containing an occlusion therein. The method includes inserting an intramural crossing device into the vascular lumen, positioning at least the distal tip of the crossing device in the vascular wall, advancing an orienting device over the crossing device such that an orienting element of the orienting device resides in the vascular wall, inserting a reentry device, and re-entering the true vascular lumen.

A variety of configurations of implant management devices are provided. The configurations provide different combinations of features for maintaining a location of an implant with respect to the device and managing filaments of the implant. One exemplary embodiment of a device includes a generally rectangular-shaped body having an implantable body retainer, an opening disposed a distance apart from the retainer and configured to receive a ligament graft therein, and a fold extending across the body and intersecting the opening. Folding one end of the body towards a bottom surface of the body along the fold can form a filament loop engaging region to hold in tension a filament loop extending from the implant. Additional filament(s) associated with the implant can be managed by various filament retention features. Methods for preparing a ligament graft for implantation by relying upon indicia formed on a surface of the device body are also provided.

An endovascular catheter for vein ablation comprising: an elongated rod sized for insertion into a vein; at least one irritation element coupled to the distal end portion of the rod, the at least one irritation element having an expanded irritation state for contacting an inner wall segment of the vein to irritate the vein segment to trigger spasm of the vein segment and a non-irritation state, the at least one irritation element arranged for iterative changes between the irritation state and the non-irritation state; and at least one support element coupled to the distal end portion of the rod, the support element arranged to apply a mechanical force from the distal end portion to iteratively return the irritation element to the expanded irritation state in response to dynamic feedback of vein walls pressing against the irritation element to force the irritation element into the non-irritation state.

Unitary vessel harvesting devices with integrated components is provided. In some embodiments, such devices comprise an elongated body having a proximal end and a distal end, a dissection tip disposed at the distal end of the elongated body. The dissection tip can include integrated circuitry to provide an in-tip camera, lighting and data communications.

Apparatus and methods are provided for occluding blood vessels and other anatomical structures. Occlusion devices are delivered percutaneously and extraluminally through a small gauge needle and include expandable elements that are deployable on opposite sides of a target vessel to be occluded. When positioned about the vessel the elements are expanded and brought together to compress and occlude the vessel. Embodiments include those adapted for temporary as well as permanent use.

A catheter including a cutting element and an insertion tube, wherein the springy resilient cutting element (1) consists of a sleeve (1a) and profiled longitudinal arms (1b) with sharp endings (1c), protruding from it and directed towards an atraumatic tip (7), wherein the element (1) is mounted on an assembly (2) of an inner tube.

A variety of configurations of implant management devices are provided. The configurations provide different combinations of features for maintaining a location of an implant with respect to the device and managing filaments of the implant. One exemplary embodiment of a device includes a generally rectangular-shaped body having an implantable body retainer, an opening disposed a distance apart from the retainer and configured to receive a ligament graft therein, and a fold extending across the body and intersecting the opening. Folding one end of the body towards a bottom surface of the body along the fold can form a filament loop engaging region to hold in tension a filament loop extending from the implant. Additional filament(s) associated with the implant can be managed by various filament retention features. Methods for preparing a ligament graft for implantation by relying upon indicia formed on a surface of the device body are also provided.