The present invention relates to a therapeutic substance delivery device for delivering a therapeutic substance to a desired site in a bodily duct, characterized in that the therapeutic substance delivery device is provided with: a therapeutic substance loading portion; a connector which is connected to the therapeutic substance loading portion; and a supplying/discharging pipe connected to the connector; and in that the therapeutic substance loading portion includes a main body portion in which a recessed portion is formed, a resilient film, and a connecting pipe; the connector is provided with a joint main body, a flange portion fixed to the other end portion side of the joint main body, and a fixing nut through which the joint main body passes; the joint main body is provided with a tube fastening portion; and at least part of the inner wall of the fixing nut is provided with a thread.

Systems, instruments, methods, and compositions are described involving removing a portion of the epidermis within a donor site on a subject, and harvesting dermal plugs within the donor site. An injectable filler is formed by mincing the dermal plugs. The injectable filler is configured for injecting into a recipient site on the subject.

A system and method for harvesting autologous tissue, mincing it into fragments that are visible and measureable when filtered, and delivering a portion of the tissue back into the patient without the need to directly touch the tissue. During the same surgical procedure, the tissue can be mixed with a biocompatible agent before introduction into the repair site.

Apparatus is described that includes a blade assembly (20) for conditioning ex vivo pericardial tissue from which fibers extend. The apparatus includes a blade head (26) that includes a blade a may (28) and a face (30) defining gaps (32) therein. The gaps are dimensioned to facilitate protrusion therethrough of fibers into the blade head, such that movement of the blade array, with respect to the face, shears the fibers. The blade assembly is configured to be used while the tissue and the blade array are submerged in a liquid (140) with the fibers facing upward, and with the face facing downward. The apparatus is configured to provide, while the blade array is submerged in the liquid, a suction force that sucks the liquid into the blade head via the gaps, and discharges a refuse liquid through a lateral exhaust hole (24). Other embodiments are also described.

Devices and methods for extraction and processing of substantiagelatineafuniculi umbilicalis (Wharton's Jelly) from an umbilical cord.

The invention discloses an in vivo organ transfer device, which comprises an organ fixing bag and an organ bag push assembly, wherein the organ fixing bag is composed of an inner bag and an outer bag, the outer bag is provided with an ice water filling hole and a link rod fixing interfaces, multiple groups of link rod fixing interfaces are arranged on both sides of the outer bag, and the inner layer bag is provided with an organ inlet, an input conduit opening and an output conduit opening. The invention belongs to the technical field of in vivo organ transfer, in particular relates to an in vivo organ transfer device that can provide good temperature conditions in the organ implantation process and it can fix the transplant in the reconstruction process to make the transplant in the optimum location and angle most conducive to the conduit suturing, creating favorable conditions for minimally invasive organ transplantation.

Embodiments of the disclosure are directed to a ligament repair system and method. The ligament repair system may include one or more of a femoral aimer assembly, a tibial aimer assembly, a femoral fixation assembly, and a tibial fixation assembly.

Provided herein is a delivery system, including: (a) an optical sensor configured to detect data to create a map of a patient bodily surface; and (b) a dispenser operatively associated with the optical sensor and configured to deliver compositions (optionally including cells) to the patient bodily surface based upon the data or map. Methods of forming a tissue on a patient bodily surface of a patient in need thereof are also provided, as are methods, systems and computer program products useful for processing patient bodily surface data.

The present disclosure provides a mechanically-actuated tool for cutting a tissue graft having a hollow core and methods for use thereof. A portion of a biological structure, such as a nerve, is attached to the hollow core to form an implantable neural graft assembly. The tool has a cutter mechanism and a grasper mechanism. The grasper mechanism has one or more component(s) that open and close via an actuation mechanism, like a handle, and rotate via a controller component, like a rotatable wheel. The cutter mechanism may be a cutting tube component that harvests the tissue graft. The tool may also have an ejector mechanism to remove the tissue graft as part of the implantable neural graft assembly. Such devices and methods are particularly suitable for treating neuromas and other neural regeneration procedures.

The present disclosure provides a mechanically-actuated tool for cutting a tissue graft having a hollow core and methods for use thereof. A portion of a biological structure, such as a nerve, is attached to the hollow core to form an implantable neural graft assembly. The tool has a cutter mechanism and a grasper mechanism. The grasper mechanism has one or more component(s) that open and close via an actuation mechanism, like a handle, and rotate via a controller component, like a rotatable wheel. The cutter mechanism may be a cutting tube component that harvests the tissue graft. The tool may also have an ejector mechanism to remove the tissue graft as part of the implantable neural graft assembly. Such devices and methods are particularly suitable for treating neuromas and other neural regeneration procedures.